Phenotype Image Detail

Image

Caption

Pikfyve^{Gt(AT0926)Wtsi}/Pikfyve^{Gt(AT0926)Wtsi} (Pikfyve^{Beta-geo/Beta-geo}) mutants have degeneration in the spleen and kidneys. Homozygous mutants that survived past 1 week showed significant degeneration in the kidney. (A) H&E-stained spleen from P16 homozygous pups revealed that the spleen had less cellular density, and numerous vacuoles were present. (B) H&E-stained kidney from homozygous P0 pups showed multiple small vacuoles in the renal tubules (arrow). The overall structure of the glomeruli was unaffected. (C) H&E-stained kidney from homozygous P19 pups revealed more extensive degeneration than observed in the kidney of P0 pups. Some of the tubules were filled with vacuoles (arrowhead).

Copyright

This image is from Zolov SN, Proc Natl Acad Sci U S A 2012 Oct 23;109(43):17472-7. Copyright 2012 National Academy of Sciences, U.S.A. J:190368

Associated Alleles

Symbol	Name
Pikfyve^Gt(AT0926)Wtsi	phosphoinositide kinase, FYVE type zinc finger containing; gene trap AT0926, Wellcome Trust Sanger Institute

Associated Genotypes

Allelic Composition	Genetic Background
Pikfyve^Gt(AT0926)Wtsi/Pikfyve^Gt(AT0926)Wtsi	involves: 129P2/OlaHsd * C57BL/6