Phenotype Image Detail

Image

Caption

Growth retardation and peripheral blood morphology in postnatal Picalm^tm1Towa/Picalm^tm1Towa (-/-) mice. (A) Wild-type (+/+) (left) and Picalm^tm1Towa/Picalm^tm1Towa (-/-) (right) mice at 3 weeks of age. (B) Average weight of wild-type (+/+) and mutant (-/-) mice at postnatal day 28. Data shown represent mutant males (n = 3), mutant females (n = 4), wild-type males (n = 36), and wild-type females (n = 35). **, P < 0.01 vs control. Liver (C), spleen (D) and tibia (E) from wild-type (+/+) or mutant (-/-) mice at 3 weeks of age. (F) Bone marrow cells were collected by centrifugation. Note that the pellet from mutant (-/-) mice is small and pale in color. (G) Quantification of TER119-positive bone marrow cells (data represent means +/- SD; n = 5). *, P < 0.05 vs. control. (H) Peripheral blood smears from wild-type (+/+) littermates (left panels, a and c) or mutant (-/-) mice (right panels, b and d) at 3 weeks of age. Magnification: upper panels, 400x; lower panels, 1000x. Scale bar, 50 um (upper panel) and 20 um (lower panel).

Copyright

This image is from Suzuki M, PLoS One 2012;7(2):e31854, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:185312

Associated Alleles

Symbol	Name
Picalm^tm1Towa	phosphatidylinositol binding clathrin assembly protein; targeted mutation 1, Toshio Watanabe

Associated Genotypes

Allelic Composition	Genetic Background
Picalm^tm1Towa/Picalm^tm1Towa	involves: C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj