Picalm^tm1Towa
Targeted Allele Detail

Summary

• Symbol: Picalm^tm1Towa
• Name: phosphatidylinositol binding clathrin assembly protein; targeted mutation 1, Toshio Watanabe
• MGI ID: MGI:5430167
• Synonyms: CALM^-
• Gene: Picalm Location: Chr7:89779418-89858655 bp, + strand Genetic Position: Chr7, 50.47 cM
• Alliance: Picalm^tm1Towa page

Growth retardation and anemia in Picalm^tm1Towa/Picalm^tm1Towa mice

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:185312
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

Allele Type: Targeted (Null/knockout) Mutation: Insertion Mutation details: A neo gene was inserted in exon 1 downstream of the translation initiation site. Western blot analysis confirmed the absence of protein expression in mouse embryonic fibroblasts. (J:185312)

Generation of the Picalm^tm1Towa allele

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Picalm Mutation: 42 strains or lines available

References

• Original: J:185312 Suzuki M, et al., The clathrin assembly protein PICALM is required for erythroid maturation and transferrin internalization in mice. PLoS One. 2012;7(2):e31854
• All: 4 reference(s)