Phenotype Image Detail

Image

Caption

Histological examination of the skin from the trunk (Fig. 5B, 5D, 5F, 5H) and feet (Fig. 5A, 5C, 5E, 5G) of male and female Gnas^tm1Gwa/Gnas⁺ mice with maternally inherited (-m/+) and paternally inherited (-p/+) Gnas allele reveal mineralized bone formation often associated with a dense eosinophilic osteoid-like matrix in the dermis and perifollicular areas. No abnormalities were observed in wild-type mice. Occasional osteoid-like material was present without bone, immediately adjacent to hair follicles, especially in female mutant mice which had milder lesions (Fig. 5F, 5H). Subcutaneous bone frequently contained central bone marrow elements making it histologically indistinguishable from mature skeletal bone (Fig. 5B, 5D). Scale bars = 50 um.

Copyright

This image is from Huso DL, PLoS One 2011;6(6):e21755, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:174525

Associated Alleles

Symbol	Name
Gnas^tm1Gwa	GNAS complex locus; targeted mutation 1, Gary Wand

Associated Genotypes

Allelic Composition	Genetic Background
Gnas^tm1Gwa/Gnas^+	involves: 129S/SvEv * 129S4/SvJae