Phenotype Image Detail

Image

Caption

Characterization of progressive iridocorneal angle closures in Vav2^tm1Kdf/Vav2^tm1Kdf Vav3^tm1Swat/Vav3^tm1Swat and Vav2^tm1Kdf/Vav2^tm1Kdf mice. The aqueous humor outflow facility, trabecular meshwork (TM) and Schlemm's canal (SC) (iridocorneal angle) in Vav2^tm1Kdf/Vav2^tm1Kdf Vav3^tm1Swat/Vav3^tm1Swat (Vav2-/- Vav3^-/-) mice are evaluated in histological manner. Vav2^tm1Kdf/Vav2^tm1Kdf (Vav2^-/-) mice also have the same changes, but of lower severity. A. Representative photos of normal TM and SC histology of 12 week-old wild-type (WT) mice as a control. Representative photos of normal open angle, peripheral anterior synechiae (PAS) in 12 week-old double mutant mice, and angle closure status in 12 week old double mutant mice. Sections used here are all representative from 20 samples. Scale bars: left photos, 200 um; right photos, 100 um. B. Changes of angle status appear at the early ages. We classify angle status of Vav2^tm1Kdf/Vav2^tm1Kdf Vav3^tm1Swat/Vav3^tm1Swat, Vav2^tm1Kdf/Vav2^tm1Kdf, and Vav3^tm1Swat/Vav3^tm1Swat (Vav3^-/-) mice into open angle, PAS, and angle closure by histological evaluation. We find the changes of angle status at the early ages, such as 18 day old mutant mice (n = 20) and in 4 week old double mutant mice (n = 20). We took four (Vav2^tm1Kdf/Vav2^tm1Kdf Vav3^tm1Swat/Vav3^tm1Swat) and three (Vav2^tm1Kdf/Vav2^tm1Kdf and Vav3^tm1Swat/Vav3^tm1Swat) different age groups, with 20 mice examined, respectively.

Copyright

This image is from Fujikawa K, PLoS One 2010;5(2):e9050, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:158008

Associated Alleles

Symbol	Name
Vav2^tm1Kdf	vav 2 oncogene; targeted mutation 1, Klaus-Dieter Fischer
Vav3^tm1Swat	vav 3 oncogene; targeted mutation 1, Wojciech Swat

Associated Genotypes

Allelic Composition	Genetic Background
Vav2^tm1Kdf/Vav2^tm1Kdf	B6.129S1-Vav2^tm1Kdf
Vav2^tm1Kdf/Vav2^tm1Kdf Vav3^tm1Swat/Vav3^tm1Swat	B6.129S-Vav2^tm1Kdf Vav3^tm1Swat