Phenotype Image Detail

Image

Caption

Phenotypic analysis of Ugt1^tm1Rhtu/Ugt1^tm1Rhtu mice. A: As early as 8 hours after birth, the elevated concentrations of unconjugated serum bilirubin are displayed in neonatal mice as jaundice and easily identified by skin color. A litter generated from crossing Ugt1^tm1Rhtu/Ugt1⁺ mice shows a single Ugt1^tm1Rhtu/Ugt1^tm1Rhtu (Ugt1^-/-) neonatal mouse with littermates that are either heterozygous or wild-type. The appearance of jaundice is also contrasted in a side by side photograph. B: Life span of 18 neonatal mutant mice. The majority of the mice die before day 7.

This image is from Nguyen N, J Biol Chem 2008 Mar 21;283(12):7901-11 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:133790

Associated
Alleles

Symbol	Name
Ugt1^tm1Rhtu	UDP glucuronosyltransferase 1 complex; targeted mutation 1, Robert H Tukey

Associated
Genotypes

Allelic Composition	Genetic Background
Ugt1^tm1Rhtu/Ugt1^tm1Rhtu	involves: 129 * C57BL/6

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