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Targeted Allele Detail
Symbol: Ugt1tm1Rhtu
Name: UDP glucuronosyltransferase 1 complex; targeted mutation 1, Robert H Tukey
MGI ID: MGI:3784509
Synonyms: Ugt1-
Gene: Ugt1  Location: unknown  Genetic Position: Chr1, Syntenic
Ugt1tm1Rhtu/Ugt1tm1Rhtu mice are jaundiced and show postnatal lethality

Show the 1 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:133790
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsA neo cassette was inserted into exon 4 interrupting amino acid thr-413 and leu-414. The absence of protein products was confirmed by western blot analysis on liver extracts. Northern blot analysis confirmed the absence of all Ugt1a family RNAs in homozygous liver. Conjugation activity using bilirubin or T4 as substrates was absent from homozygous liver extracts. (J:133790)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ugt1 Mutation:  2 strains or lines available
Original:  J:133790 Nguyen N, et al., Disruption of the ugt1 locus in mice resembles human Crigler-Najjar type I disease. J Biol Chem. 2008 Mar 21;283(12):7901-11
All:  12 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.22
The Jackson Laboratory