Phenotype Image Detail

Image

Caption

Analysis of an E17.5dpc F7^tm1Pec/F7^tm1Pec Proc^tm1Fjc/Proc^tm1Fjc embryo. A: Gross appearance displaying significant internal and peripheral hemorrhage and edema. B-C: Hematoxylin and eosin staining of liver sections indicating areas of fibrosis within one of the lobes (arrow) (b); anti-fibrinogen immunostaining of parallel liver sections demonstrating interstitial fibrin deposition (brown) around these fibrotic patches (c). D-G: Histological analyses of hindbrain sections indicating areas of hemorrhage (d), fibrin deposition (e), collagen deposition (blue) (f), and the presence of CD45-positive leukocytes (brown) (g). H-J: Histological analyses of atrial sections confirming the presence of blood in the atria (h), fibrin deposition (i), and internal collagen invasion around these areas of fibrin (j).

Copyright

This image is from Chan JC, J Clin Invest 2000 Apr;105(7):897-903 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:61481

Associated Alleles

Symbol	Name
F7^tm1Pec	coagulation factor VII; targeted mutation 1, Peter Carmeliet
Proc^tm1Fjc	protein C; targeted mutation 1, Francis J Castellino

Associated Genotypes

Allelic Composition	Genetic Background
F7^tm1Pec/F7^tm1Pec Proc^tm1Fjc/Proc^tm1Fjc	involves: 129S1/Sv * 129X1/SvJ * C57BL/6