Phenotype Image Detail

Image

Caption

A: Periodic acid Schiff's staining of postischemic kidneys. Shown are stainings for wild type (WT, Upper Left), Bdkrb2^tm1Jfh/Bdkrb2^tm1Jfh (B2R-null, Upper Right), and Bdkrb2/Bdkrb1^tm1Mki/Bdkrb2/Bdkrb1^tm1Mki (B1RB2R-null, Lower) mice. Scale bar, 100um. B: Semiquantitative scoring for histological changes in the proximal tubule according to the criteria of Jablonski et al. (56). The sham-operated mice all a score of zero. The black columns show the scores of the ischemia groups. P<0.05 vs WT; P<0.05 vs. B2R-null. The data are means +/- standard errors, with the numbers of mice shown in white digits.

Copyright

This image is from Kakoki M, Proc Natl Acad Sci U S A 2007 May 1;104(18):7576-81. Copyright 2007 National Academy of Sciences, U.S.A. J:121339

Associated Alleles

Symbol	Name
Bdkrb2/Bdkrb1^tm1Mki	bradykinin receptor, beta 2; targeted mutation 1, Masao Kakoki
Bdkrb2/Bdkrb1^tm1Mki	bradykinin receptor, beta 1; targeted mutation 1, Masao Kakoki
Bdkrb2^tm1Jfh	bradykinin receptor, beta 2; targeted mutation 1, J Fred Hess

Associated Genotypes

Allelic Composition	Genetic Background
Bdkrb2^tm1Jfh/Bdkrb2^tm1Jfh	B6.129S7-Bdkrb2^tm1Jfh
Bdkrb2/Bdkrb1^tm1Mki/Bdkrb2/Bdkrb1^tm1Mki	involves: C57BL/6J
Bdkrb2/Bdkrb1^tm1Mki/Bdkrb2/Bdkrb1^tm1Mki	involves: C57BL/6J