Phenotype Image Detail

Image

Caption

Nissl staining of control (Gba^tm2Karl/Gba⁺ Tg(KRT14-cre)8Brn/?) mice (A-D) and Gba1^tm2Karl/Gba1^tm2Karl Tg(KRT14-cre)8Brn/? mice (E-F). Loss of neurons was observed in red nucleus (E), pons (F) medulla (G) and cerebellum (H). Purkinje neurons (indicated by arrows in D and H) are reduced in numbers and appear shrunken. All mice were about 2 weeks old at analysis. Scale bar in A & E, 30um; B and F, 60um; C and G, 50um; D and H, 40um.

Copyright

This image is from Enquist IB, Proc Natl Acad Sci U S A 2007 Oct 30;104(44):17483-8. Copyright 2007 National Academy of Sciences, U.S.A. J:127108

Associated Alleles

Symbol	Name
Gba1^tm2Karl	glucosylceramidase beta 1; targeted mutation 2, Stefan Karlsson
Tg(KRT14-cre)8Brn	transgene insertion 8, Anton Berns

Associated Genotypes

Allelic Composition	Genetic Background
Gba1^tm2Karl/Gba1^tm2Karl Tg(KRT14-cre)8Brn/?	involves: 129S1/Sv * 129X1/SvJ * FVB/N