Phenotype Image Detail

Image

Caption

A: Accumulation of megakaryocytes in the bone marrow and spleen of Gata1^Plt13/Gata1⁺ mice. In comparison with the wild type mouse tissues (left), there are a significant number of megakaryocytes demonstrated hyperchromatic nuclei and a reduced amount of cytoplasm (arrows) in the heterozygote tissues (right). B: Electron micrographs of megakaryocytes from wild-type mice demonstrate the expansive cytoplasm and complex demarcation membrane system that are characteristic of these cells. Heterozygous mouse megakaryocytes have large, multilobed nuclei but generally have reduced cytoplasm with a poorly developed demarcation membrane system. Scale bar: 5um

Copyright

This image is from Majewski IJ, Proc Natl Acad Sci U S A 2006 Sep 19;103(38):14146-51. Copyright 2006 National Academy of Sciences, U.S.A. J:113720

Associated Alleles

Symbol	Name
Gata1^Plt13	GATA binding protein 1; Plt13

Associated Genotypes

Allelic Composition	Genetic Background
Gata1^Plt13/Gata1^+	BALB/c-Gata1^Plt13