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Phenotype Image Detail
Caption Immunohistochemical staining (anti-insulin, anti-glucagon) of pancreatic islets from Ins2tm1Jja/Ins2tm1Jja mice (A & D) and Ins1tm1Jja/Ins1tm1Jja mice (C & F). As early as 10 weeks of age, beta cells are destroyed in the Ins2tm1Jja/Ins2tm1Jja mice with extensive insulitis. In contrast, insulin-containing beta cells remain without insulitis for an older Ins1tm1Jja/+ male at 48 weeks (B & E) and an Ins1tm1Jja/Ins1tm1Jja female at 37 weeks.
Copyright This image is from Moriyama H, Proc Natl Acad Sci U S A 2003 Sep 2;100(18):10376-81. Copyright 2003 National Academy of Sciences, U.S.A. J:85309
Symbol Name
Ins1tm1Jja insulin I; targeted mutation 1, Jacques Jami
Ins2tm1Jja insulin II; targeted mutation 1, Jacques Jami
Allelic Composition Genetic Background
Ins1tm1Jja/Ins1tm1Jja NOD.129S2-Ins1tm1Jja
Ins2tm1Jja/Ins2tm1Jja NOD.129S2-Ins2tm1Jja

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