Phenotype Image Detail

Image

Caption

Immunohistochemical staining (anti-insulin, anti-glucagon) of pancreatic islets from Ins2^tm1Jja/Ins2^tm1Jja mice (A & D) and Ins1^tm1Jja/Ins1^tm1Jja mice (C & F). As early as 10 weeks of age, beta cells are destroyed in the Ins2^tm1Jja/Ins2^tm1Jja mice with extensive insulitis. In contrast, insulin-containing beta cells remain without insulitis for an older Ins1^tm1Jja/⁺ male at 48 weeks (B & E) and an Ins1^tm1Jja/Ins1^tm1Jja female at 37 weeks.

Copyright

This image is from Moriyama H, Proc Natl Acad Sci U S A 2003 Sep 2;100(18):10376-81. Copyright 2003 National Academy of Sciences, U.S.A. J:85309

Associated Alleles

Symbol	Name
Ins1^tm1Jja	insulin I; targeted mutation 1, Jacques Jami
Ins2^tm1Jja	insulin II; targeted mutation 1, Jacques Jami

Associated Genotypes

Allelic Composition	Genetic Background
Ins1^tm1Jja/Ins1^tm1Jja	NOD.129S2-Ins1^tm1Jja
Ins2^tm1Jja/Ins2^tm1Jja	NOD.129S2-Ins2^tm1Jja