LRP6 Vertebrate HGNC

Vertebrate Homology

Source

Alliance of Genome Resources

Comparative GO Graph (mouse, human, rat, zebrafish)

Alliance Homology Information

Species	Symbol	Gene Links	Genetic Location	Genome Coordinates (mouse and human only)	Associated Human Diseases	Sequences select all deselect all Go
human	LRP6	HGNC:6698 (HGNC) 4040 (Entrez Gene) 603507 (OMIM) LRP6 (Alliance of Genome Resources)	Chr12 p13.2	Chr12:12116025-12267044 (-) GRCh38	tooth agenesis	O75581 (UniProt \| EBI) NM_001414245 (RefSeq)
mouse	Lrp6	MGI:1298218 (MGI) 16974 (Entrez Gene) Gene Tree Lrp6 (Alliance of Genome Resources)	Chr6 65.37 cM	Chr6:134423439-134543876 (-) GRCm39	neural tube defect steatotic liver disease	16974 (NCBI Gene Model) O88572 (UniProt \| EBI) NM_008514 (RefSeq)
rat	Lrp6	RGD:1304749 (Rat Genome Database) 312781 (Entrez Gene) Lrp6 (Alliance of Genome Resources)	Chr4 q43			NP_001101362 (RefSeq) NM_001401820 (RefSeq)
zebrafish	lrp6	ZDB-GENE-090821-1 (Zebrafish Model Organism Database) 100003877 (Entrez Gene) lrp6 (Alliance of Genome Resources)	Chr4			NP_001128156 (RefSeq) NM_001134684 (RefSeq)

Alliance Homology Information

MGI loads orthology data based on the 'stringent' set from the Alliance of Genome Resources. The Alliance sets are based on a scoring system developed by the Alliance in collaboration with DIOPT.

MGI includes orthology for the following vertebrate species from the Alliance:
- human
- mouse
- rat
- zebrafish

These are a subset of the total species represented in the Alliance; there may be stringent set orthologs in other Alliance species.

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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