Gene Expression Literature Summary

• Symbol: Src
• Name: Rous sarcoma oncogene
• ID: MGI:98397

49 matching records from 49 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E0.5	E1	E2	E2.5	E3	E3.5	E7.5	E8.5	E9	E9.5	E10.5	E11.5	E12	E12.5	E13	E13.5	E14	E14.5	E15	E15.5	E16	E16.5	E17.5	E18	E18.5	E20	E	P
Immunohistochemistry (section)		1				1		1		1	5	3		1		1		2				1			1	1		2
In situ RNA (section)												1					1				1			1				1
Immunohistochemistry (whole mount)		1		1	1	1
Northern blot							1	1		1	1	1		1		1		1		1		1	1		1
Western blot								2		1	1			3				5		3		2	1		1		1	13
RT-PCR	1	1	1	1	1	1			1	1	2	1	1		1	1	1		1	1	1		2		1		1	5
cDNA clones										1	1	1				1												1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Src  Rous sarcoma oncogene   (Synonyms: pp60c-src)
Results	Reference
3*	J:40680 Aizawa S, Yagi T, Furuta Y, Ikawa Y, Nada S, Nakagawa H, Okada M, Non-receptor tyrosine kinases in mammalian neurogenesis. Princess Takamatsu Symp. 1994;24:323-37
1	J:109820 Arnaud L, Ballif BA, Forster E, Cooper JA, Fyn tyrosine kinase is a critical regulator of disabled-1 during brain development. Curr Biol. 2003 Jan 8;13(1):9-17
1	J:327336 Bertol JW, Johnston S, Ahmed R, Xie VK, Hubka KM, Cruz L, Nitschke L, Stetsiv M, Goering JP, Nistor P, Lowell S, Hoskens H, Claes P, Weinberg SM, Saadi I, Farach-Carson MC, Fakhouri WD, TWIST1 interacts with beta/delta-catenins during neural tube development and regulates fate transition in cranial neural crest cells. Development. 2022 Aug 1;149(15):dev200068
4*	J:93300 Blackshaw S, Harpavat S, Trimarchi J, Cai L, Huang H, Kuo WP, Weber G, Lee K, Fraioli RE, Cho SH, Yung R, Asch E, Ohno-Machado L, Wong WH, Cepko CL, Genomic analysis of mouse retinal development. PLoS Biol. 2004 Oct;2(9):E247
1	J:109819 Bock HH, Herz J, Reelin activates SRC family tyrosine kinases in neurons. Curr Biol. 2003 Jan 8;13(1):18-26
2	J:311855 Brudvig JJ, Cain JT, Schmidt-Grimminger GG, Stumpo DJ, Roux KJ, Blackshear PJ, Weimer JM, MARCKS Is Necessary for Netrin-DCC Signaling and Corpus Callosum Formation. Mol Neurobiol. 2018 Nov;55(11):8388-8402
1	J:144338 Chai X, Forster E, Zhao S, Bock HH, Frotscher M, Reelin stabilizes the actin cytoskeleton of neuronal processes by inducing n-cofilin phosphorylation at serine3. J Neurosci. 2009 Jan 7;29(1):288-99
1	J:188341 Chen WV, Alvarez FJ, Lefebvre JL, Friedman B, Nwakeze C, Geiman E, Smith C, Thu CA, Tapia JC, Tasic B, Sanes JR, Maniatis T, Functional significance of isoform diversification in the protocadherin gamma gene cluster. Neuron. 2012 Aug 9;75(3):402-9
1*	J:157804 Corsi JM, Houbron C, Billuart P, Brunet I, Bouvree K, Eichmann A, Girault JA, Enslen H, Autophosphorylation-independent and -dependent functions of focal adhesion kinase during development. J Biol Chem. 2009 Dec 11;284(50):34769-76
2	J:190411 Dong Y, Zhang L, Zhang S, Bai Y, Chen H, Sun X, Yong W, Li W, Colvin SC, Rhodes SJ, Shou W, Zhang ZY, Phosphatase of regenerating liver 2 (PRL2) is essential for placental development by down-regulating PTEN (Phosphatase and Tensin Homologue Deleted on Chromosome 10) and activating Akt protein. J Biol Chem. 2012 Sep 14;287(38):32172-9
3	J:137570 Eminaga S, Bennett AM, Noonan syndrome-associated SHP-2/Ptpn11 mutants enhance SIRPalpha and PZR tyrosyl phosphorylation and promote adhesion-mediated ERK activation. J Biol Chem. 2008 May 30;283(22):15328-38
3*	J:46439 Freeman TC, Dixon AK, Campbell EA, Tait TM, Richardson PJ, Rice KM, Maslen GL, Metcalfe AD, Streuli CH, Bentley DR, Expression Mapping of Mouse Genes. MGI Direct Data Submission. 1998;
1	J:106994 Georgakopoulos A, Litterst C, Ghersi E, Baki L, Xu C, Serban G, Robakis NK, Metalloproteinase/Presenilin1 processing of ephrinB regulates EphB-induced Src phosphorylation and signaling. EMBO J. 2006 Mar 22;25(6):1242-52
12*	J:176139 Giannatselis H, Calder M, Watson AJ, Ouabain Stimulates a Na/K-ATPase-Mediated SFK-Activated Signalling Pathway That Regulates Tight Junction Function in the Mouse Blastocyst. PLoS One. 2011;6(8):e23704
1	J:280117 Gong X, Guo X, Huang R, Liao H, Zhang Q, Yan J, Luo L, Zhang Q, Qiu A, Sun Y, Liang X, Expression of ILK in renal stroma is essential for multiple aspects of renal development. Am J Physiol Renal Physiol. 2018 Aug 1;315(2):F374-F385
1	J:307823 Hoover C, Kondo Y, Shao B, McDaniel MJ, Lee R, McGee S, Whiteheart S, Bergmeier W, McEver RP, Xia L, Heightened activation of embryonic megakaryocytes causes aneurysms in the developing brain of mice lacking podoplanin. Blood. 2021 May 20;137(20):2756-2769
2*	J:112731 Huang J, Sakai R, Furuichi T, The docking protein Cas links tyrosine phosphorylation signaling to elongation of cerebellar granule cell axons. Mol Biol Cell. 2006 Jul;17(7):3187-96
2	J:106956 Isosaka T, Hattori K, Yagi T, NMDA-receptor proteins are upregulated in the hippocampus of postnatal heterozygous reeler mice. Brain Res. 2006 Feb 16;1073-1074:11-9
3	J:148253 Kao TJ, Palmesino E, Kania A, SRC family kinases are required for limb trajectory selection by spinal motor axons. J Neurosci. 2009 Apr 29;29(17):5690-700
1	J:217426 Kitase Y, Shuler CF, Palatal adhesion is dependent on Src family kinases and p38MAPK. Int J Dev Biol. 2014;58(5):335-41
1	J:101055 Kuo G, Arnaud L, Kronstad-O'Brien P, Cooper JA, Absence of Fyn and Src causes a reeler-like phenotype. J Neurosci. 2005 Sep 14;25(37):8578-86
1	J:168643 Kusaka M, Katoh-Fukui Y, Ogawa H, Miyabayashi K, Baba T, Shima Y, Sugiyama N, Sugimoto Y, Okuno Y, Kodama R, Iizuka-Kogo A, Senda T, Sasaoka T, Kitamura K, Aizawa S, Morohashi K, Abnormal epithelial cell polarity and ectopic epidermal growth factor receptor (EGFR) expression induced in Emx2 KO embryonic gonads. Endocrinology. 2010 Dec;151(12):5893-904
2	J:51720 Laviola L, Giorgino F, Chow JC, Baquero JA, Hansen H, Ooi J, Zhu J, Riedel H, Smith RJ, The adapter protein Grb10 associates preferentially with the insulin receptor as compared with the IGF-I receptor in mouse fibroblasts. J Clin Invest. 1997 Mar 1;99(5):830-7
1	J:338829 Lee J, Kim Y, Ataliotis P, Kim HG, Kim DW, Bennett DC, Brown NA, Layman LC, Kim SH, Coordination of canonical and noncanonical Hedgehog signalling pathways mediated by WDR11 during primordial germ cell development. Sci Rep. 2023 Jul 29;13(1):12309
2	J:232444 Li S, Moore AK, Zhu J, Li X, Zhou H, Lin J, He Y, Xing F, Pan Y, Bohler HC, Ding J, Cooney AJ, Lan Z, Lei Z, Ggnbp2 Is Essential for Pregnancy Success via Regulation of Mouse Trophoblast Stem Cell Proliferation and Differentiation. Biol Reprod. 2016 Feb;94(2):41
2	J:185949 Licatalosi DD, Yano M, Fak JJ, Mele A, Grabinski SE, Zhang C, Darnell RB, Ptbp2 represses adult-specific splicing to regulate the generation of neuronal precursors in the embryonic brain. Genes Dev. 2012 Jul 15;26(14):1626-42
1	J:165360 Lim ST, Chen XL, Tomar A, Miller NL, Yoo J, Schlaepfer DD, Knock-in mutation reveals an essential role for focal adhesion kinase activity in blood vessel morphogenesis and cell motility-polarity but not cell proliferation. J Biol Chem. 2010 Jul 9;285(28):21526-36
1*	J:177766 Lindquist S, Karitkina D, Langnaese K, Posevitz-Fejfar A, Schraven B, Xavier R, Seed B, Lindquist JA, Phosphoprotein associated with glycosphingolipid-enriched microdomains differentially modulates SRC kinase activity in brain maturation. PLoS One. 2011;6(9):e23978
5	J:268025 Makeyev EV, Zhang J, Carrasco MA, Maniatis T, The MicroRNA miR-124 promotes neuronal differentiation by triggering brain-specific alternative pre-mRNA splicing. Mol Cell. 2007 Aug 3;27(3):435-48
1*	J:98227 Miyamoto Y, Chen L, Sato M, Sokabe M, Nabeshima T, Pawson T, Sakai R, Mori N, Hippocampal synaptic modulation by the phosphotyrosine adapter protein ShcC/N-Shc via interaction with the NMDA receptor. J Neurosci. 2005 Feb 16;25(7):1826-35
1	J:182886 Moik DV, Janbandhu VC, Fassler R, Loss of migfilin expression has no overt consequences on murine development and homeostasis. J Cell Sci. 2011 Feb 1;124(Pt 3):414-21
1	J:50997 Morse WR, Whitesides JG 3rd, LaMantia AS, Maness PF, p59fyn and pp60c-src modulate axonal guidance in the developing mouse olfactory pathway. J Neurobiol. 1998 Jul;36(1):53-63
1	J:244898 Nakamura F, Okada T, Shishikura M, Uetani N, Taniguchi M, Yagi T, Iwakura Y, Ohshima T, Goshima Y, Strittmatter SM, Protein Tyrosine Phosphatase delta Mediates the Sema3A-Induced Cortical Basal Dendritic Arborization through the Activation of Fyn Tyrosine Kinase. J Neurosci. 2017 Jul 26;37(30):7125-7139
1	J:254421 Otowa Y, Moriwaki K, Sano K, Shirakabe M, Yonemura S, Shibuya M, Rossant J, Suda T, Kakeji Y, Hirashima M, Flt1/VEGFR1 heterozygosity causes transient embryonic edema. Sci Rep. 2016 Jun 2;6:27186
1	J:165694 Roselli S, Wallez Y, Wang L, Vervoort V, Pasquale EB, The SH2 domain protein Shep1 regulates the in vivo signaling function of the scaffolding protein Cas. Cell Signal. 2010 Nov;22(11):1745-52
1	J:205551 Simo S, Cooper JA, Rbx2 regulates neuronal migration through different cullin 5-RING ligase adaptors. Dev Cell. 2013 Nov 25;27(4):399-411
12	J:178367 Slamon DJ, Cline MJ, Expression of cellular oncogenes during embryonic and fetal development of the mouse. Proc Natl Acad Sci U S A. 1984 Nov;81(22):7141-5
1	J:27414 Sommers CL, Huang K, Shores EW, Grinberg A, Charlick DA, Kozak CA, Love PE, Murine txk: a protein tyrosine kinase gene regulated by T cell activation. Oncogene. 1995 Jul 20;11(2):245-51
3*	J:194960 Tai G, Hohenstein P, Davies JA, FAK-Src signalling is important to renal collecting duct morphogenesis: discovery using a hierarchical screening technique. Biol Open. 2013;2:416-423
1	J:242317 Tan J, Chen XJ, Shen CL, Zhang HX, Tang LY, Lu SY, Wu WT, Kuang Y, Fei J, Wang ZG, Lacking of palladin leads to multiple cellular events changes which contribute to NTD. Neural Dev. 2017 Mar 24;12(1):4
3	J:91730 Verma-Kurvari S, Parada LF, Identification of tyrosine kinases expressed in the male mouse gubernaculum during development. Dev Dyn. 2004 Aug;230(4):660-5
11*	J:55945 Wang JP, Chuang SM, Shen CL, Chen ST, Expression of Src family during development of the mouse nervous system. Biomed Res. 1998 OCT;19(5):315-325
1	J:164874 Wang L, Vervoort V, Wallez Y, Core N, Cremer H, Pasquale EB, The SRC homology 2 domain protein Shep1 plays an important role in the penetration of olfactory sensory axons into the forebrain. J Neurosci. 2010 Sep 29;30(39):13201-10
1	J:330212 Wang S, Tanaka Y, Xu Y, Takeda S, Hirokawa N, KIF3B promotes a PI3K signaling gradient causing changes in a Shh protein gradient and suppressing polydactyly in mice. Dev Cell. 2022 Oct 10;57(19):2273-2289.e11
1*	J:155069 Yam PT, Langlois SD, Morin S, Charron F, Sonic hedgehog guides axons through a noncanonical, Src-family-kinase-dependent signaling pathway. Neuron. 2009 May 14;62(3):349-62
1*	J:321158 Young IC, Wu B, Andricovich J, Chuang ST, Li R, Tzatsos A, Wu RC, Wu MY, Differentiation of fetal hematopoietic stem cells requires ARID4B to restrict autocrine KITLG/KIT-Src signaling. Cell Rep. 2021 Nov 23;37(8):110036
1	J:271268 Yui S, Azzolin L, Maimets M, Pedersen MT, Fordham RP, Hansen SL, Larsen HL, Guiu J, Alves MRP, Rundsten CF, Johansen JV, Li Y, Madsen CD, Nakamura T, Watanabe M, Nielsen OH, Schweiger PJ, Piccolo S, Jensen KB, YAP/TAZ-Dependent Reprogramming of Colonic Epithelium Links ECM Remodeling to Tissue Regeneration. Cell Stem Cell. 2018 Jan 4;22(1):35-49.e7
1	J:300786 Zhang Z, Ye M, Li Q, You Y, Yu H, Ma Y, Mei L, Sun X, Wang L, Yue W, Li R, Li J, Zhang D, The Schizophrenia Susceptibility Gene OPCML Regulates Spine Maturation and Cognitive Behaviors through Eph-Cofilin Signaling. Cell Rep. 2019 Oct 1;29(1):49-61.e7
1	J:43438 Zhu Y, Qi C, Jain S, Rao MS, Reddy JK, Isolation and characterization of PBP, a protein that interacts with peroxisome proliferator-activated receptor. J Biol Chem. 1997 Oct 10;272(41):25500-6