Gene Expression Literature Summary
|
Symbol Name ID |
Shh
sonic hedgehog MGI:98297 |
| Age | E0.5 | E1.5 | E2 | E6.5 | E7 | E7.5 | E8 | E8.5 | E9 | E9.5 | E10 | E10.5 | E11 | E11.5 | E12 | E12.5 | E13 | E13.5 | E14 | E14.5 | E15 | E15.5 | E16 | E16.5 | E17 | E17.5 | E18 | E18.5 | E19 | E19.5 | E20 | E | P |
| Immunohistochemistry (section) | 1 | 5 | 21 | 9 | 68 | 4 | 122 | 7 | 46 | 6 | 49 | 2 | 20 | 2 | 21 | 3 | 14 | 1 | 15 | 2 | 8 | 4 | 13 | 1 | 1 | 10 | 37 | ||||||
| In situ RNA (section) | 7 | 13 | 53 | 24 | 132 | 20 | 174 | 16 | 151 | 13 | 185 | 11 | 131 | 20 | 150 | 15 | 84 | 12 | 53 | 6 | 31 | 3 | 45 | 3 | 1 | 34 | 74 | ||||||
| Immunohistochemistry (whole mount) | 1 | 3 | 2 | 1 | 4 | 1 | 7 | 1 | 4 | 2 | 2 | 2 | 2 | 2 | 1 | 1 | 1 | ||||||||||||||||
| In situ RNA (whole mount) | 1 | 3 | 44 | 62 | 127 | 52 | 171 | 50 | 291 | 60 | 207 | 36 | 131 | 17 | 70 | 14 | 69 | 3 | 23 | 3 | 7 | 1 | 2 | 1 | 4 | 1 | 51 | 3 | |||||
| In situ reporter (knock in) | 1 | 3 | 3 | 5 | 1 | 11 | 4 | 6 | 4 | 7 | 2 | 5 | 1 | 8 | 3 | 1 | 4 | 3 | 1 | 2 | 1 | 1 | 10 | ||||||||||
| Northern blot | 1 | 1 | 2 | 2 | 1 | 2 | 2 | 4 | 1 | 1 | 3 | 2 | 1 | 3 | |||||||||||||||||||
| Western blot | 5 | 1 | 3 | 5 | 2 | 1 | 3 | 2 | 3 | 1 | 2 | 1 | 3 | 5 | 8 | ||||||||||||||||||
| RT-PCR | 1 | 1 | 1 | 2 | 2 | 8 | 4 | 26 | 6 | 39 | 8 | 36 | 3 | 40 | 3 | 39 | 6 | 48 | 2 | 32 | 5 | 28 | 3 | 18 | 2 | 35 | 1 | 2 | 10 | 65 | |||
| cDNA clones | 2 | 1 | 1 | 3 | |||||||||||||||||||||||||||||
| RNase protection | 1 | 1 | 1 |
| Shh sonic hedgehog (Synonyms: Hhg1) | |
| Results | Reference |
| 1 | J:278544 Abdelhamed ZA, Abdelmottaleb DI, El-Asrag ME, Natarajan S, Wheway G, Inglehearn CF, Toomes C, Johnson CA, The ciliary Frizzled-like receptor Tmem67 regulates canonical Wnt/beta-catenin signalling in the developing cerebellum via Hoxb5. Sci Rep. 2019 Apr 1;9(1):5446 |
| 1* | J:223384 Abdelhamed ZA, Natarajan S, Wheway G, Inglehearn CF, Toomes C, Johnson CA, Jagger DJ, The Meckel-Gruber syndrome protein TMEM67 controls basal body positioning and epithelial branching morphogenesis in mice via the non-canonical Wnt pathway. Dis Model Mech. 2015 Jun;8(6):527-41 |
| 1 | J:193837 Abdelhamed ZA, Wheway G, Szymanska K, Natarajan S, Toomes C, Inglehearn C, Johnson CA, Variable expressivity of ciliopathy neurological phenotypes that encompass Meckel-Gruber syndrome and Joubert syndrome is caused by complex de-regulated ciliogenesis, Shh and Wnt signalling defects. Hum Mol Genet. 2013 Apr 1;22(7):1358-72 |
| 1 | J:237454 Abdulhaleem FA, Song X, Kawano R, Uezono N, Ito A, Ahmed G, Hossain M, Nakashima K, Tanaka H, Ohta K, Akhirin regulates the proliferation and differentiation of neural stem cells in intact and injured mouse spinal cord. Dev Neurobiol. 2015 May;75(5):494-504 |
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| 2 | J:150706 Abler LL, Mansour SL, Sun X, Conditional gene inactivation reveals roles for Fgf10 and Fgfr2 in establishing a normal pattern of epithelial branching in the mouse lung. Dev Dyn. 2009 Jul 17;238(8):1999-2013 |
| 5 | J:314668 Abrams SR, Reiter JF, Ciliary Hedgehog signaling regulates cell survival to build the facial midline. Elife. 2021 Oct 21;10:e68558 |
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| 2* | J:82633 Adamska M, MacDonald BT, Meisler MH, Doubleridge, a mouse mutant with defective compaction of the apical ectodermal ridge and normal dorsal-ventral patterning of the limb. Dev Biol. 2003 Mar 15;255(2):350-62 |
| 2* | J:92327 Adamska M, MacDonald BT, Sarmast ZH, Oliver ER, Meisler MH, En1 and Wnt7a interact with Dkk1 during limb development in the mouse. Dev Biol. 2004 Aug 1;272(1):134-44 |
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| 7 | J:168361 Ahn Y, Sanderson BW, Klein OD, Krumlauf R, Inhibition of Wnt signaling by Wise (Sostdc1) and negative feedback from Shh controls tooth number and patterning. Development. 2010 Oct;137(19):3221-31 |
| 2* | J:243416 Ahn Y, Sims C, Murray MJ, Kuhlmann PK, Fuentes-Antras J, Weatherbee SD, Krumlauf R, Multiple modes of Lrp4 function in modulation of Wnt/beta-catenin signaling during tooth development. Development. 2017 Aug 01;144(15):2824-2836 |
| 1 | J:106499 Airik R, Bussen M, Singh MK, Petry M, Kispert A, Tbx18 regulates the development of the ureteral mesenchyme. J Clin Invest. 2006 Mar;116(3):663-74 |
| 2 | J:291223 Aizawa R, Yamada A, Seki T, Tanaka J, Nagahama R, Ikehata M, Kato T, Sakashita A, Ogata H, Chikazu D, Maki K, Mishima K, Yamamoto M, Kamijo R, Cdc42 regulates cranial suture morphogenesis and ossification. Biochem Biophys Res Commun. 2019 Apr 30;512(2):145-149 |
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| 1 | J:79879 Akiyama H, Chaboissier MC, Martin JF, Schedl A, De Crombrugghe B, The transcription factor Sox9 has essential roles in successive steps of the chondrocyte differentiation pathway and is required for expression of Sox5 and Sox6. Genes Dev. 2002 Nov 1;16(21):2813-28 |
| 1 | J:121946 Akiyama H, Stadler HS, Martin JF, Ishii TM, Beachy PA, Nakamura T, de Crombrugghe B, Misexpression of Sox9 in mouse limb bud mesenchyme induces polydactyly and rescues hypodactyly mice. Matrix Biol. 2007 May;26(4):224-33 |
| 1 | J:207610 Akiyama R, Kawakami H, Taketo MM, Evans SM, Wada N, Petryk A, Kawakami Y, Distinct populations within Isl1 lineages contribute to appendicular and facial skeletogenesis through the beta-catenin pathway. Dev Biol. 2014 Mar 1;387(1):37-48 |
| 2 | J:220960 Akiyama R, Kawakami H, Wong J, Oishi I, Nishinakamura R, Kawakami Y, Sall4-Gli3 system in early limb progenitors is essential for the development of limb skeletal elements. Proc Natl Acad Sci U S A. 2015 Apr 21;112(16):5075-80 |
| 1* | J:187602 Al Alam D, Sala FG, Baptista S, Galzote R, Danopoulos S, Tiozzo C, Gage P, Grikscheit T, Warburton D, Frey MR, Bellusci S, FGF9-Pitx2-FGF10 signaling controls cecal formation in mice. Dev Biol. 2012 Sep 15;369(2):340-8 |
| 2 | J:326544 Alam SS, Kumar S, Beauchamp MC, Bareke E, Boucher A, Nzirorera N, Dong Y, Padilla R, Zhang SJ, Majewski J, Jerome-Majewska LA, Snrpb is required in murine neural crest cells for proper splicing and craniofacial morphogenesis. Dis Model Mech. 2022 Jun 1;15(6):dmm049544 |
| 1 | J:69637 Alavizadeh A, Kiernan AE, Nolan P, Lo C, Steel KP, Bucan M, The wheels mutation in the mouse causes vascular, hindbrain, and inner ear defects. Dev Biol. 2001 Jun 1;234(1):244-60 |
| 1 | J:72920 Alberta JA, Park SK, Mora J, Yuk D, Pawlitzky I, Iannarelli P, Vartanian T, Stiles CD, Rowitch DH, Sonic hedgehog is required during an early phase of oligodendrocyte development in mammalian brain. Mol Cell Neurosci. 2001 Oct;18(4):434-41 |
| 3* | J:75699 Albrecht AN, Schwabe GC, Stricker S, Boddrich A, Wanker EE, Mundlos S, The synpolydactyly homolog (spdh) mutation in the mouse -- a defect in patterning and growth of limb cartilage elements. Mech Dev. 2002 Mar;112(1-2):53-67 |
| 6 | J:173604 Allen BL, Song JY, Izzi L, Althaus IW, Kang JS, Charron F, Krauss RS, McMahon AP, Overlapping Roles and Collective Requirement for the Coreceptors GAS1, CDO, and BOC in SHH Pathway Function. Dev Cell. 2011 Jun 14;20(6):775-87 |
| 1 | J:121553 Allen BL, Tenzen T, McMahon AP, The Hedgehog-binding proteins Gas1 and Cdo cooperate to positively regulate Shh signaling during mouse development. Genes Dev. 2007 May 15;21(10):1244-57 |
| 1* | J:119563 Alt B, Elsalini OA, Schrumpf P, Haufs N, Lawson ND, Schwabe GC, Mundlos S, Gruters A, Krude H, Rohr KB, Arteries define the position of the thyroid gland during its developmental relocalisation. Development. 2006 Oct;133(19):3797-804 |
| 1 | J:182741 Alten L, Schuster-Gossler K, Beckers A, Groos S, Ulmer B, Hegermann J, Ochs M, Gossler A, Differential regulation of node formation, nodal ciliogenesis and cilia positioning by Noto and Foxj1. Development. 2012 Apr;139(7):1276-84 |
| 1* | J:98302 Altick AL, Dravis C, Bowdler T, Henkemeyer M, Mastick GS, EphB receptor tyrosine kinases control morphological development of the ventral midbrain. Mech Dev. 2005 Apr;122(4):501-12 |
| 2 | J:178985 Alvarez JI, Dodelet-Devillers A, Kebir H, Ifergan I, Fabre PJ, Terouz S, Sabbagh M, Wosik K, Bourbonniere L, Bernard M, van Horssen J, de Vries HE, Charron F, Prat A, The Hedgehog pathway promotes blood-brain barrier integrity and CNS immune quiescence. Science. 2011 Dec 23;334(6063):1727-31 |
| 8 | J:181298 Alvarez-Bolado G, Paul FA, Blaess S, Sonic hedgehog lineage in the mouse hypothalamus: from progenitor domains to hypothalamic regions. Neural Dev. 2012;7(1):4 |
| 1 | J:225216 Alvarez-Saavedra M, De Repentigny Y, Lagali PS, Raghu Ram EV, Yan K, Hashem E, Ivanochko D, Huh MS, Yang D, Mears AJ, Todd MA, Corcoran CP, Bassett EA, Tokarew NJ, Kokavec J, Majumder R, Ioshikhes I, Wallace VA, Kothary R, Meshorer E, Stopka T, Skoultchi AI, Picketts DJ, Snf2h-mediated chromatin organization and histone H1 dynamics govern cerebellar morphogenesis and neural maturation. Nat Commun. 2014;5:4181 |
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| 1 | J:309392 Amano K, Densmore MJ, Lanske B, Conditional Deletion of Indian Hedgehog in Limb Mesenchyme Results in Complete Loss of Growth Plate Formation but Allows Mature Osteoblast Differentiation. J Bone Miner Res. 2015 Dec;30(12):2262-72 |
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| 2 | J:207519 Anderegg A, Lin HP, Chen JA, Caronia-Brown G, Cherepanova N, Yun B, Joksimovic M, Rock J, Harfe BD, Johnson R, Awatramani R, An Lmx1b-miR135a2 regulatory circuit modulates Wnt1/Wnt signaling and determines the size of the midbrain dopaminergic progenitor pool. PLoS Genet. 2013 Dec;9(12):e1003973 |
| 3* | J:217498 Anderson E, Devenney PS, Hill RE, Lettice LA, Mapping the Shh long-range regulatory domain. Development. 2014 Oct;141(20):3934-43 |
| 3* | J:79855 Anderson RM, Lawrence AR, Stottmann RW, Bachiller D, Klingensmith J, Chordin and noggin promote organizing centers of forebrain development in the mouse. Development. 2002 Nov;129(21):4975-87 |
| 1* | J:111609 Anderson RM, Stottmann RW, Choi M, Klingensmith J, Endogenous bone morphogenetic protein antagonists regulate mammalian neural crest generation and survival. Dev Dyn. 2006 Aug 7;235(9):2507-2520 |
| 2 | J:144081 Andersson ER, Prakash N, Cajanek L, Minina E, Bryja V, Bryjova L, Yamaguchi TP, Hall AC, Wurst W, Arenas E, Wnt5a regulates ventral midbrain morphogenesis and the development of A9-A10 dopaminergic cells in vivo. PLoS One. 2008;3(10):e3517 |
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| 1* | J:108723 Andersson O, Reissmann E, Jornvall H, Ibanez CF, Synergistic interaction between Gdf1 and Nodal during anterior axis development. Dev Biol. 2006 May 15;293(2):370-81 |
| 5* | J:170250 Ando T, Semba K, Suda H, Sei A, Mizuta H, Araki M, Abe K, Imai K, Nakagata N, Araki K, Yamamura K, The floor plate is sufficient for development of the sclerotome and spine without the notochord. Mech Dev. 2011 Jan-Feb;128(1-2):129-40 |
| 2 | J:181005 Andoniadou CL, Signore M, Young RM, Gaston-Massuet C, Wilson SW, Fuchs E, Martinez-Barbera JP, HESX1- and TCF3-mediated repression of Wnt/beta-catenin targets is required for normal development of the anterior forebrain. Development. 2011 Nov;138(22):4931-42 |
| 2 | J:220460 Andre P, Song H, Kim W, Kispert A, Yang Y, Wnt5a and Wnt11 regulate mammalian anterior-posterior axis elongation. Development. 2015 Apr 15;142(8):1516-27 |
| 4* | J:198100 Andreeva V, Cardarelli J, Yelick PC, Rb1 mRNA expression in developing mouse teeth. Gene Expr Patterns. 2012 Mar-Apr;12(3-4):130-5 |
| 9 | J:273860 Andreu-Cervera A, Anselme I, Karam A, Laclef C, Catala M, Schneider-Maunoury S, The Ciliopathy Gene Ftm/Rpgrip1l Controls Mouse Forebrain Patterning via Region-Specific Modulation of Hedgehog/Gli Signaling. J Neurosci. 2019 Mar 27;39(13):2398-2415 |
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| 1 | J:272589 Ankamreddy H, Min H, Kim JY, Yang X, Cho ES, Kim UK, Bok J, Region-specific endodermal signals direct neural crest cells to form the three middle ear ossicles. Development. 2019 Jan 22;146(2):dev167965 |
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| 4 | J:145732 Aoto K, Shikata Y, Imai H, Matsumaru D, Tokunaga T, Shioda S, Yamada G, Motoyama J, Mouse Shh is required for prechordal plate maintenance during brain and craniofacial morphogenesis. Dev Biol. 2009 Mar 1;327(1):106-20 |
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| 4* | J:290235 Archambault D, Cheong A, Iverson E, Tremblay KD, Mager J, Protein phosphatase 1 regulatory subunit 35 is required for ciliogenesis, notochord morphogenesis, and cell-cycle progression during murine development. Dev Biol. 2020 Jul 3;465(1):1-10 |
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| 2 | J:291194 Aryal YP, Neupane S, Adhikari N, An CH, Ha JH, Kwon TY, Yamamoto H, Jung JK, Park EK, Kim JY, Cho SW, Sohn WJ, Lee Y, Chae HJ, Kim HR, Kim JY, An endoplasmic reticulum stress regulator, Tmbim6, modulates secretory stage of mice molar. J Cell Physiol. 2019 Nov;234(11):20354-20365 |
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| 1 | J:328140 Asgarian Z, Oliveira MG, Stryjewska A, Maragkos I, Rubin AN, Magno L, Pachnis V, Ghorbani M, Hiebert SW, Denaxa M, Kessaris N, MTG8 interacts with LHX6 to specify cortical interneuron subtype identity. Nat Commun. 2022 Sep 5;13(1):5217 |
| 2* | J:181888 Ashe A, Butterfield NC, Town L, Courtney AD, Cooper AN, Ferguson C, Barry R, Olsson F, Liem KF Jr, Parton RG, Wainwright BJ, Anderson KV, Whitelaw E, Wicking C, Mutations in mouse Ift144 model the craniofacial, limb and rib defects in skeletal ciliopathies. Hum Mol Genet. 2012 Apr 15;21(8):1808-23 |
| 1 | J:186055 Ashique AM, Choe Y, Karlen M, May SR, Phamluong K, Solloway MJ, Ericson J, Peterson AS, The Rfx4 transcription factor modulates Shh signaling by regional control of ciliogenesis. Sci Signal. 2009;2(95):ra70 |
| 1 | J:290418 Ashokkumar D, Zhang Q, Much C, Bledau AS, Naumann R, Alexopoulou D, Dahl A, Goveas N, Fu J, Anastassiadis K, Stewart AF, Kranz A, MLL4 is required after implantation, whereas MLL3 becomes essential during late gestation. Development. 2020 Jun 17;147(12):dev186999 |
| 1 | J:78219 Aubin J, Dery U, Lemieux M, Chailler P, Jeannotte L, Stomach regional specification requires Hoxa5-driven mesenchymal-epithelial signaling. Development. 2002 Sep;129(17):4075-87 |
| 1 | J:223814 Aujla PK, Bogdanovic V, Naratadam GT, Raetzman LT, Persistent expression of activated notch in the developing hypothalamus affects survival of pituitary progenitors and alters pituitary structure. Dev Dyn. 2015 Aug;244(8):921-34 |
| 2* | J:135300 Babbs C, Furniss D, Morriss-Kay GM, Wilkie AO, Polydactyly in the mouse mutant Doublefoot involves altered Gli3 processing and is caused by a large deletion in cis to Indian hedgehog. Mech Dev. 2008 May-Jun;125(5-6):517-26 |
| 1 | J:60303 Bachiller D, Klingensmith J, Kemp C, Belo JA, Anderson RM, May SR, McMahon JA, McMahon AP, Harland RM, Rossant J, De Robertis EM, The organizer factors Chordin and Noggin are required for mouse forebrain development. Nature. 2000 Feb 10;403(6770):658-61 |
| 1 | J:170583 Baek JA, Lan Y, Liu H, Maltby KM, Mishina Y, Jiang R, Bmpr1a signaling plays critical roles in palatal shelf growth and palatal bone formation. Dev Biol. 2011 Feb 15;350(2):520-31 |
| 7 | J:110211 Baek JH, Hatakeyama J, Sakamoto S, Ohtsuka T, Kageyama R, Persistent and high levels of Hes1 expression regulate boundary formation in the developing central nervous system. Development. 2006 Jul;133(13):2467-76 |
| 6* | J:79392 Bai CB, Auerbach W, Lee JS, Stephen D, Joyner AL, Gli2, but not Gli1, is required for initial Shh signaling and ectopic activation of the Shh pathway. Development. 2002 Oct;129(20):4753-61 |
| 1* | J:73074 Bai CB, Joyner AL, Gli1 can rescue the in vivo function of Gli2. Development. 2001 Dec;128(24):5161-72 |
| 1 | J:87948 Bai CB, Stephen D, Joyner AL, All mouse ventral spinal cord patterning by hedgehog is Gli dependent and involves an activator function of Gli3. Dev Cell. 2004 Jan;6(1):103-15 |
| 3 | J:311885 Bandiera R, Vidal VP, Motamedi FJ, Clarkson M, Sahut-Barnola I, von Gise A, Pu WT, Hohenstein P, Martinez A, Schedl A, WT1 maintains adrenal-gonadal primordium identity and marks a population of AGP-like progenitors within the adrenal gland. Dev Cell. 2013 Oct 14;27(1):5-18 |
| 1 | J:334460 Bando H, Brinkmeier ML, Castinetti F, Fang Q, Lee MS, Saveanu A, Albarel F, Dupuis C, Brue T, Camper SA, Heterozygous variants in SIX3 and POU1F1 cause pituitary hormone deficiency in mouse and man. Hum Mol Genet. 2023 Jan 13;32(3):367-385 |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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