Gene Expression Literature Summary

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Shh  sonic hedgehog   (Synonyms: Hhg1)
Results	Reference
1	J:278544 Abdelhamed ZA, Abdelmottaleb DI, El-Asrag ME, Natarajan S, Wheway G, Inglehearn CF, Toomes C, Johnson CA, The ciliary Frizzled-like receptor Tmem67 regulates canonical Wnt/beta-catenin signalling in the developing cerebellum via Hoxb5. Sci Rep. 2019 Apr 1;9(1):5446
1	J:309392 Amano K, Densmore MJ, Lanske B, Conditional Deletion of Indian Hedgehog in Limb Mesenchyme Results in Complete Loss of Growth Plate Formation but Allows Mature Osteoblast Differentiation. J Bone Miner Res. 2015 Dec;30(12):2262-72
1	J:139130 Breunig JJ, Sarkisian MR, Arellano JI, Morozov YM, Ayoub AE, Sojitra S, Wang B, Flavell RA, Rakic P, Town T, Primary cilia regulate hippocampal neurogenesis by mediating sonic hedgehog signaling. Proc Natl Acad Sci U S A. 2008 Sep 2;105(35):13127-32
1	J:150524 Chan JA, Balasubramanian S, Witt RM, Nazemi KJ, Choi Y, Pazyra-Murphy MF, Walsh CO, Thompson M, Segal RA, Proteoglycan interactions with Sonic Hedgehog specify mitogenic responses. Nat Neurosci. 2009 Apr;12(4):409-17
1	J:155992 Ching S, Vilain E, Targeted disruption of Sonic Hedgehog in the mouse adrenal leads to adrenocortical hypoplasia. Genesis. 2009 Sep;47(9):628-37
1*	J:73075 Dahmane N, Sanchez P, Gitton Y, Palma V, Sun T, Beyna M, Weiner H, Ruiz i Altaba A, The Sonic Hedgehog-Gli pathway regulates dorsal brain growth and tumorigenesis. Development. 2001 Dec;128(24):5201-12
1	J:170236 El-Hashash AH, Al Alam D, Turcatel G, Bellusci S, Warburton D, Eyes absent 1 (Eya1) is a critical coordinator of epithelial, mesenchymal and vascular morphogenesis in the mammalian lung. Dev Biol. 2011 Feb 1;350(1):112-26
1*	J:201184 Ferrara AM, Liao XH, Gil-Ibanez P, Marcinkowski T, Bernal J, Weiss RE, Dumitrescu AM, Refetoff S, Changes in thyroid status during perinatal development of MCT8-deficient male mice. Endocrinology. 2013 Jul;154(7):2533-41
1*	J:143073 Fujieda H, Bremner R, Mears AJ, Sasaki H, Retinoic acid receptor-related orphan receptor alpha regulates a subset of cone genes during mouse retinal development. J Neurochem. 2009 Jan;108(1):91-101
1	J:288683 Gacem N, Kavo A, Zerad L, Richard L, Mathis S, Kapur RP, Parisot M, Amiel J, Dufour S, de la Grange P, Pingault V, Vallat JM, Bondurand N, ADAR1 mediated regulation of neural crest derived melanocytes and Schwann cell development. Nat Commun. 2020 Jan 10;11(1):198
1	J:101172 Gao N, Ishii K, Mirosevich J, Kuwajima S, Oppenheimer SR, Roberts RL, Jiang M, Yu X, Shappell SB, Caprioli RM, Stoffel M, Hayward SW, Matusik RJ, Forkhead box A1 regulates prostate ductal morphogenesis and promotes epithelial cell maturation. Development. 2005 Aug;132(15):3431-43
1	J:87181 Gold DA, Baek SH, Schork NJ, Rose DW, Larsen DD, Sachs BD, Rosenfeld MG, Hamilton BA, RORalpha coordinates reciprocal signaling in cerebellar development through sonic hedgehog and calcium-dependent pathways. Neuron. 2003 Dec 18;40(6):1119-31
1	J:65293 Hebrok M, Kim SK, St Jacques B, McMahon AP, Melton DA, Regulation of pancreas development by hedgehog signaling. Development. 2000 Nov;127(22):4905-13
1*	J:154891 Hirose Y, Itoh T, Miyajima A, Hedgehog signal activation coordinates proliferation and differentiation of fetal liver progenitor cells. Exp Cell Res. 2009 Sep 10;315(15):2648-57
1	J:236236 Hong CJ, Hamilton BA, Zfp423 Regulates Sonic Hedgehog Signaling via Primary Cilium Function. PLoS Genet. 2016 Oct;12(10):e1006357
1	J:309463 Hor CHH, Lo JCW, Cham ALS, Leong WY, Goh ELK, Multifaceted Functions of Rab23 on Primary Cilium-Mediated and Hedgehog Signaling-Mediated Cerebellar Granule Cell Proliferation. J Neurosci. 2021 Aug 11;41(32):6850-6863
1	J:339059 Ihn HJ, Kim JA, Lim J, Nam SH, Hwang SH, Kim YK, Kim JY, Kim JE, Cho ES, Jiang R, Park EK, Bobby sox homolog regulates tooth root formation through modulation of dentin sialophosphoprotein. J Cell Physiol. 2021 Jan;236(1):480-488
1	J:242713 Ikeda Y, Zabbarova I, Schaefer CM, Bushnell D, De Groat WC, Kanai A, Bates CM, Fgfr2 is integral for bladder mesenchyme patterning and function. Am J Physiol Renal Physiol. 2017 Apr 01;312(4):F607-F618
1	J:114852 Jiang F, Herman GE, Analysis of Nsdhl-deficient embryos reveals a role for Hedgehog signaling in early placental development. Hum Mol Genet. 2006 Nov 15;15(22):3293-305
1	J:135131 Kashiwagi M, Morgan BA, Georgopoulos K, The chromatin remodeler Mi-2beta is required for establishment of the basal epidermis and normal differentiation of its progeny. Development. 2007 Apr;134(8):1571-82
1	J:151258 Kolterud A, Grosse AS, Zacharias WJ, Walton KD, Kretovich KE, Madison BB, Waghray M, Ferris JE, Hu C, Merchant JL, Dlugosz AA, Kottmann AH, Gumucio DL, Paracrine Hedgehog signaling in stomach and intestine: new roles for hedgehog in gastrointestinal patterning. Gastroenterology. 2009 Aug;137(2):618-28
1	J:191495 Kucerova R, Dora N, Mort RL, Wallace K, Leiper LJ, Lowes C, Neves C, Walczysko P, Bruce F, Fowler PA, Rajnicek AM, McCaig CD, Zhao M, West JD, Collinson JM, Interaction between hedgehog signalling and PAX6 dosage mediates maintenance and regeneration of the corneal epithelium. Mol Vis. 2012;18:139-50
1	J:147576 Kunisada M, Cui CY, Piao Y, Ko MS, Schlessinger D, Requirement for Shh and Fox family genes at different stages in sweat gland development. Hum Mol Genet. 2009 May 15;18(10):1769-78
1	J:78990 Lamm ML, Catbagan WS, Laciak RJ, Barnett DH, Hebner CM, Gaffield W, Walterhouse D, Iannaccone P, Bushman W, Sonic hedgehog activates mesenchymal Gli1 expression during prostate ductal bud formation. Dev Biol. 2002 Sep 15;249(2):349-66
1	J:291514 Lee J, Shin JE, Lee B, Kim H, Jeon Y, Ahn SH, Chi SW, Cho Y, The stem cell marker Prom1 promotes axon regeneration by down-regulating cholesterol synthesis via Smad signaling. Proc Natl Acad Sci U S A. 2020 Jul 7;117(27):15955-15966
1	J:42408 Lewis MT, Ross S, Strickland PA, Sugnet CW, Jimenez E, Scott MP, Daniel CW, Defects in mouse mammary gland development caused by conditional haploinsufficiency of Patched-1. Development. 1999 Nov;126(22):5181-93
1*	J:217750 Lim A, Shin K, Zhao C, Kawano S, Beachy PA, Spatially restricted Hedgehog signalling regulates HGF-induced branching of the adult prostate. Nat Cell Biol. 2014 Dec;16(12):1135-45
1	J:222787 Liu C, Peng J, Matzuk MM, Yao HH, Lineage specification of ovarian theca cells requires multicellular interactions via oocyte and granulosa cells. Nat Commun. 2015;6:6934
1	J:279065 Liu W, Han F, Qu S, Yao Y, Zhao J, Akhtar ML, Ci Y, Zhang H, Li H, Zhao Y, Yue L, Zhang Y, Wang C, Li Y, MARVELD1 depletion leads to dysfunction of motor and cognition via regulating glia-dependent neuronal migration during brain development. Cell Death Dis. 2018 Sep 24;9(10):999
1*	J:78334 Liu W, Li G, Chien JS, Raft S, Zhang H, Chiang C, Frenz DA, Sonic hedgehog regulates otic capsule chondrogenesis and inner ear development in the mouse embryo. Dev Biol. 2002 Aug 15;248(2):240-50
1	J:175083 Lorenz A, Deutschmann M, Ahlfeld J, Prix C, Koch A, Smits R, Fodde R, Kretzschmar HA, Schuller U, Severe alterations of cerebellar cortical development after constitutive activation of wnt signaling in granule neuron precursors. Mol Cell Biol. 2011 Aug;31(16):3326-38
1*	J:221341 Lun MP, Johnson MB, Broadbelt KG, Watanabe M, Kang YJ, Chau KF, Springel MW, Malesz A, Sousa AM, Pletikos M, Adelita T, Calicchio ML, Zhang Y, Holtzman MJ, Lidov HG, Sestan N, Steen H, Monuki ES, Lehtinen MK, Spatially heterogeneous choroid plexus transcriptomes encode positional identity and contribute to regional CSF production. J Neurosci. 2015 Mar 25;35(12):4903-16
1	J:255932 Mario Gonzalez-Meljem J, Haston S, Carreno G, Apps JR, Pozzi S, Stache C, Kaushal G, Virasami A, Panousopoulos L, Neda Mousavy-Gharavy S, Guerrero A, Rashid M, Jani N, Goding CR, Jacques TS, Adams DJ, Gil J, Andoniadou CL, Pedro Martinez-Barbera J, Stem cell senescence drives age-attenuated induction of pituitary tumours in mouse models of paediatric craniopharyngioma. Nat Commun. 2017 Nov 28;8(1):1819
1	J:269227 Mathieu M, Drelon C, Rodriguez S, Tabbal H, Septier A, Damon-Soubeyrand C, Dumontet T, Berthon A, Sahut-Barnola I, Djari C, Batisse-Lignier M, Pointud JC, Richard D, Kerdivel G, Calmejane MA, Boeva V, Tauveron I, Lefrancois-Martinez AM, Martinez A, Val P, Steroidogenic differentiation and PKA signaling are programmed by histone methyltransferase EZH2 in the adrenal cortex. Proc Natl Acad Sci U S A. 2018 Dec 26;115(52):E12265-E12274
1	J:334074 McCoy AM, Lakhdari O, Shome S, Caoili K, Hernandez GE, Aghaeepour N, Butcher LD, Fisch K, Prince LS, Sp3 is essential for normal lung morphogenesis and cell cycle progression during mouse embryonic development. Development. 2023 Mar 1;150(5):dev200839
1	J:152818 Melnick M, Phair RD, Lapidot SA, Jaskoll T, Salivary gland branching morphogenesis: a quantitative systems analysis of the Eda/Edar/NFkappaB paradigm. BMC Dev Biol. 2009;9:32
1	J:139012 Mohri Y, Kato S, Umezawa A, Okuyama R, Nishimori K, Impaired hair placode formation with reduced expression of hair follicle-related genes in mice lacking Lgr4. Dev Dyn. 2008 Aug;237(8):2235-42
1*	J:51701 Motoyama J, Heng H, Crackower MA, Takabatake T, Takeshima K, Tsui LC , Hui C, Overlapping and non-overlapping Ptch2 expression with Shh during mouse embryogenesis. Mech Dev. 1998 Nov;78(1-2):81-4
1*	J:281804 Mou C, Thomason HA, Willan PM, Clowes C, Harris WE, Drew CF, Dixon J, Dixon MJ, Headon DJ, Enhanced ectodysplasin-A receptor (EDAR) signaling alters multiple fiber characteristics to produce the East Asian hair form. Hum Mutat. 2008 Dec;29(12):1405-11
1*	J:192269 Mukhopadhyay A, Krishnaswami SR, Cowing-Zitron C, Hung NJ, Reilly-Rhoten H, Burns J, Yu BD, Negative regulation of Shh levels by Kras and Fgfr2 during hair follicle development. Dev Biol. 2013 Jan 15;373(2):373-82
1	J:309378 Naveau A, Zhang B, Meng B, Sutherland MT, Prochazkova M, Wen T, Marangoni P, Jones KB, Cox TC, Ganss B, Jheon AH, Klein OD, Isl1 Controls Patterning and Mineralization of Enamel in the Continuously Renewing Mouse Incisor. J Bone Miner Res. 2017 Nov;32(11):2219-2231
1	J:220963 Nosavanh L, Yu DH, Jaehnig EJ, Tong Q, Shen L, Chen MH, Cell-autonomous activation of Hedgehog signaling inhibits brown adipose tissue development. Proc Natl Acad Sci U S A. 2015 Apr 21;112(16):5069-74
1	J:278935 Novoselova TV, Hussain M, King PJ, Guasti L, Metherell LA, Charalambous M, Clark AJL, Chan LF, MRAP deficiency impairs adrenal progenitor cell differentiation and gland zonation. FASEB J. 2018 Jun 7;:fj201701274RR
1*	J:64180 Outram SV, Varas A, Pepicelli CV, Crompton T, Hedgehog signaling regulates differentiation from double-negative to double-positive thymocyte. Immunity. 2000 Aug;13(2):187-97
1	J:234178 Perdigoto CN, Dauber KL, Bar C, Tsai PC, Valdes VJ, Cohen I, Santoriello FJ, Zhao D, Zheng D, Hsu YC, Ezhkova E, Polycomb-Mediated Repression and Sonic Hedgehog Signaling Interact to Regulate Merkel Cell Specification during Skin Development. PLoS Genet. 2016 Jul;12(7):e1006151
1	J:54642 Podlasek CA, Barnett DH, Clemens JQ, Bak PM, Bushman W, Prostate development requires Sonic hedgehog expressed by the urogenital sinus epithelium. Dev Biol. 1999 May 1;209(1):28-39
1	J:185828 Ren Y, Cowan RG, Migone FF, Quirk SM, Overactivation of hedgehog signaling alters development of the ovarian vasculature in mice. Biol Reprod. 2012 Jun;86(6):174
1	J:306807 Saito K, Michon F, Yamada A, Inuzuka H, Yamaguchi S, Fukumoto E, Yoshizaki K, Nakamura T, Arakaki M, Chiba Y, Ishikawa M, Okano H, Thesleff I, Fukumoto S, Sox21 Regulates Anapc10 Expression and Determines the Fate of Ectodermal Organ. iScience. 2020 Jul 24;23(7):101329
1	J:260403 Sanz-Navarro M, Seidel K, Sun Z, Bertonnier-Brouty L, Amendt BA, Klein OD, Michon F, Plasticity within the niche ensures the maintenance of a Sox2(+) stem cell population in the mouse incisor. Development. 2018 Jan 8;145(1):dev155929
1*	J:147982 Sehic A, Khuu C, Risnes S, Osmundsen H, Differential gene expression profiling of the molar tooth germ in peroxisome proliferator-activated receptor-alpha (PPAR-alpha) knockout mouse and in wild-type mouse: molar tooth phenotype of PPAR-alpha knockout mouse. Eur J Oral Sci. 2009 Apr;117(2):93-104
1*	J:165465 Sehic A, Risnes S, Khan QE, Khuu C, Osmundsen H, Gene expression and dental enamel structure in developing mouse incisor. Eur J Oral Sci. 2010 Apr;118(2):118-30
1	J:167067 Seidel K, Ahn CP, Lyons D, Nee A, Ting K, Brownell I, Cao T, Carano RA, Curran T, Schober M, Fuchs E, Joyner A, Martin GR, de Sauvage FJ, Klein OD, Hedgehog signaling regulates the generation of ameloblast progenitors in the continuously growing mouse incisor. Development. 2010 Nov;137(22):3753-61
1*	J:135151 Sigulinsky CL, Green ES, Clark AM, Levine EM, Vsx2/Chx10 ensures the correct timing and magnitude of Hedgehog signaling in the mouse retina. Dev Biol. 2008 May 15;317(2):560-75
1*	J:207862 Tsukiji N, Amano T, Shiroishi T, A novel regulatory element for Shh expression in the lung and gut of mouse embryos. Mech Dev. 2014 Feb;131:127-36
1	J:283457 Uijtdewilligen PJE, Versteeg EM, van de Westerlo EMA, van der Vlag J, Daamen WF, van Kuppevelt TH, Dynamic Expression of Genes Involved in Proteoglycan/Glycosaminoglycan Metabolism during Skin Development. Biomed Res Int. 2018;2018:9873471
1*	J:178818 Wang B, Harrison W, Overbeek PA, Zheng H, Transposon mutagenesis with coat color genotyping identifies an essential role for Skor2 in sonic hedgehog signaling and cerebellum development. Development. 2011 Oct;138(20):4487-97
1	J:64018 Wang CC, Biben C, Robb L, Nassir F, Barnett L, Davidson NO, Koentgen F, Tarlinton D, Harvey RP, Homeodomain factor Nkx2-3 controls regional expression of leukocyte homing coreceptor MAdCAM-1 in specialized endothelial cells of the viscera. Dev Biol. 2000 Aug 15;224(2):152-67
1	J:210128 Weiss RM, Guo S, Shan A, Shi H, Romano RA, Sinha S, Cantley LG, Guo JK, Brg1 determines urothelial cell fate during ureter development. J Am Soc Nephrol. 2013 Mar;24(4):618-26
1	J:185531 Wu H, Lu Y, Barik A, Joseph A, Taketo MM, Xiong WC, Mei L, beta-Catenin gain of function in muscles impairs neuromuscular junction formation. Development. 2012 Jul;139(13):2392-404
1*	J:332246 Xie F, Zhu X, Liu X, Chen H, Wang J, N6-methyladenosine (m6A) RNA methylation mediated by methyltransferase complex subunit WTAP regulates amelogenesis. J Biol Chem. 2022 Dec;298(12):102715
1	J:102950 Xu Q, Wonders CP, Anderson SA, Sonic hedgehog maintains the identity of cortical interneuron progenitors in the ventral telencephalon. Development. 2005 Nov;132(22):4987-98
1	J:306911 Yamashiro K, Hori K, Lai ESK, Aoki R, Shimaoka K, Arimura N, Egusa SF, Sakamoto A, Abe M, Sakimura K, Watanabe T, Uesaka N, Kano M, Hoshino M, AUTS2 Governs Cerebellar Development, Purkinje Cell Maturation, Motor Function and Social Communication. iScience. 2020 Dec 18;23(12):101820
1	J:119916 Yang HS, Hinds PW, pRb-mediated control of epithelial cell proliferation and Indian hedgehog expression in mouse intestinal development. BMC Dev Biol. 2007;7:6
1	J:328995 Zhang SF, Dai SK, Du HZ, Wang H, Li XG, Tang Y, Liu CM, The epigenetic state of EED-Gli3-Gli1 regulatory axis controls embryonic cortical neurogenesis. Stem Cell Reports. 2022 Sep 13;17(9):2064-2080
1	J:150793 Zhou S, Degan S, Potts EN, Foster WM, Sunday ME, NPAS3 is a trachealess homolog critical for lung development and homeostasis. Proc Natl Acad Sci U S A. 2009 Jul 14;106(28):11691-6