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Gene Expression Literature Summary
Symbol
Name
ID
Afp
alpha fetoprotein
MGI:87951

144 matching records from 144 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.
Age E5.5 E6 E6.5 E7 E7.5 E8 E8.5 E9 E9.5 E10 E10.5 E11 E11.5 E12 E12.5 E13 E13.5 E14 E14.5 E15 E15.5 E16 E16.5 E17 E17.5 E18 E18.5 E19.5 E A
In situ protein (section) 2 1 1 2 1 2 1 4 1 8 1 5 2 4 2 1 1 1 1 5
In situ RNA (section) 1 2 1 6 1 6 3 7 2 9 2 6 1 2 1 2 2 5 1 2 1 2 1 2 5
In situ protein (whole mount) 1 1 1 1
In situ RNA (whole mount) 1 1 2 11 2 7 6 2 2 1 3
In situ reporter (knock in) 1 2
Northern blot 1 1 1 1 1 1 1 1 2 2 1 1 2 2 2 1 1 2 7
Western blot 1 2 2 1 1 1 1 1 2 1 5
RT-PCR 1 2 1 4 2 12 1 8 5 6 1 10 8 10 6 9 3 2 13 6 19
cDNA clones 1 1 1 2 1 1 1
RNase protection 1 1 1 1 1
Nuclease S1 1 1
Primer Extension 1 1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available
Afp  alpha fetoprotein   (Synonyms: alpha-foetoprotein)
Results  Reference
2J:67892 Andrews GK, Lee DK, Ravindra R, Lichtlen P, Sirito M, Sawadogo M, Schaffner W, The transcription factors MTF-1 and USF1 cooperate to regulate mouse metallothionein-I expression in response to the essential metal zinc in visceral endoderm cells during early development. EMBO J. 2001 Mar 1;20(5):1114-22
4J:85152 Anzai H, Kamiya A, Shirato H, Takeuchi T, Miyajima A, Impaired differentiation of fetal hepatocytes in homozygous jumonji mice. Mech Dev. 2003 Jul;120(7):791-800
1J:131055 Arnold SJ, Hofmann UK, Bikoff EK, Robertson EJ, Pivotal roles for eomesodermin during axis formation, epithelium-to-mesenchyme transition and endoderm specification in the mouse. Development. 2008 Feb;135(3):501-11
1*J:8243 Awgulewitsch A, Utset MF, Hart CP, McGinnis W, Ruddle FH, Spatial restriction in expression of a mouse homoeo box locus within the central nervous system. Nature. 1986 Mar 27-Apr 2;320(6060):328-35
1J:174103 Ayres-Silva Jde P, Manso PP, Madeira MR, Pelajo-Machado M, Lenzi HL, Sequential morphological characteristics of murine fetal liver hematopoietic microenvironment in Swiss Webster mice. Cell Tissue Res. 2011 Jun;344(3):455-69
1J:157997 Beck L, Leroy C, Beck-Cormier S, Forand A, Salaun C, Paris N, Bernier A, Urena-Torres P, Prie D, Ollero M, Coulombel L, Friedlander G, The phosphate transporter PiT1 (Slc20a1) revealed as a new essential gene for mouse liver development. PLoS One. 2010;5(2):e9148
2J:61931 Beppu H, Kawabata M, Hamamoto T, Chytil A, Minowa O, Noda T, Miyazono K, BMP type II receptor is required for gastrulation and early development of mouse embryos. Dev Biol. 2000 May 1;221(1):249-58
5J:152099 Bi Y, Huang J, He Y, Zhu GH, Su Y, He BC, Luo J, Wang Y, Kang Q, Luo Q, Chen L, Zuo GW, Jiang W, Liu B, Shi Q, Tang M, Zhang BQ, Weng Y, Huang A, Zhou L, Feng T, Luu HH, Haydon RC, He TC, Tang N, Wnt antagonist SFRP3 inhibits the differentiation of mouse hepatic progenitor cells. J Cell Biochem. 2009 Jun 26;108(1):295-303
2*J:90291 Bohnsack BL, Lai L, Dolle P, Hirschi KK, Signaling hierarchy downstream of retinoic acid that independently regulates vascular remodeling and endothelial cell proliferation. Genes Dev. 2004 Jun 1;18(11):1345-58
2J:106770 Bohnsack BL, Lai L, Northrop JL, Justice MJ, Hirschi KK, Visceral endoderm function is regulated by quaking and required for vascular development. Genesis. 2006 Feb;44(2):93-104
1*J:120667 Bouzin C, Clotman F, Renauld JC, Lemaigre FP, Rousseau GG, The onecut transcription factor hepatocyte nuclear factor-6 controls B lymphopoiesis in fetal liver. J Immunol. 2003 Aug 1;171(3):1297-303
1J:31593 Cereghini S, Ott MO, Power S, Maury M, Expression patterns of vHNF1 and HNF1 homeoproteins in early postimplantation embryos suggest distinct and sequential developmental roles. Development. 1992 Nov;116(3):783-97
1J:160475 Chu J, Shen MM, Functional redundancy of EGF-CFC genes in epiblast and extraembryonic patterning during early mouse embryogenesis. Dev Biol. 2010 Jun 1;342(1):63-73
1*J:56972 Constam DB, Robertson EJ, Tissue-specific requirements for the proprotein convertase furin/SPC1 during embryonic turning and heart looping. Development. 2000 Jan;127(2):245-54
1*J:32191 Copp AJ, Estibeiro JP, Brook FA, Downs KM, Exogenous transferrin is taken up and localized by the neurulation-stage mouse embryo in vitro. Dev Biol. 1992 Oct;153(2):312-23
1J:105812 Covello KL, Kehler J, Yu H, Gordan JD, Arsham AM, Hu CJ, Labosky PA, Simon MC, Keith B, HIF-2alpha regulates Oct-4: effects of hypoxia on stem cell function, embryonic development, and tumor growth. Genes Dev. 2006 Mar 1;20(5):557-70
2J:132868 Dame C, Kirschner KM, Bartz KV, Wallach T, Hussels CS, Scholz H, Wilms tumor suppressor, Wt1, is a transcriptional activator of the erythropoietin gene. Blood. 2006 Jun 1;107(11):4282-90
1*J:153498 Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nurnberger A, SchmidtK, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
4J:188116 Dobreva MP, Lhoest L, Pereira PN, Umans L, Chuva de Sousa Lopes SM, Zwijsen A, Periostin as a biomarker of the amniotic membrane. Stem Cells Int. 2012;2012:987185
3J:67883 Downs KM, Martin GR, Bishop JM, Contrasting patterns of myc and N-myc expression during gastrulation of the mouse embryo. Genes Dev. 1989 Jun;3(6):860-9
2*J:47784 Dragatsis I, Efstratiadis A, Zeitlin A, Mouse mutant embryos lacking huntingtin are rescued from lethality by wild-type extraembryonic tissues. Development. 1998 Apr;125(8):1529-39
9J:16221 Engelhardt NV, Factor VM, Medvinsky AL, Baranov VN, Lazareva MN, Poltoranina VS, Common antigen of oval and biliary epithelial cells (A6) is a differentiation marker of epithelial and erythroid cell lineages in early development of the mouse. Differentiation. 1993 Dec;55(1):19-26
1J:68833 Episkopou V, Arkell R, Timmons PM, Walsh JJ, Andrew RL, Swan D, Induction of the mammalian node requires Arkadia function in the extraembryonic lineages. Nature. 2001 Apr 12;410(6830):825-30
4J:39656 Farrington SM, Belaoussoff M, Baron MH, Winged-helix, Hedgehog and Bmp genes are differentially expressed in distinct cell layers of the murine yolk sac. Mech Dev. 1997 Mar;62(2):197-211
8J:79500 Gabant P, Forrester L, Nichols J, Van Reeth T, De Mees C, Pajack B, Watt A, Smitz J, Alexandre H, Szpirer C, Szpirer J, Alpha-fetoprotein, the major fetal serum protein, is not essential for embryonic development but is required for female fertility. Proc Natl Acad Sci U S A. 2002 Oct 1;99(20):12865-70
5*J:79924 Greene ND, Leung KY, Wait R, Begum S, Dunn MJ, Copp AJ, Differential protein expression at the stage of neural tube closure in the mouse embryo. J Biol Chem. 2002 Nov 1;277(44):41645-51
2*J:34056 Gualdi R, Bossard P, Zheng M, Hamada Y, Coleman JR, Zaret KS, Hepatic specification of the gut endoderm in vitro: cell signaling and transcriptional control. Genes Dev. 1996 Jul 1;10(13):1670-82
2*J:171409 GUDMAP Consortium, GUDMAP: the GenitoUrinary Development Molecular Anatomy Project. http://www.gudmap.org. 2004;
4J:154032 Guo Y, Zhang X, Huang J, Zeng Y, Liu W, Geng C, Li KW, Yang D, Wu S, Wei H, Han Z, Qian X, Jiang Y, He F, Relationships between hematopoiesis and hepatogenesis in the midtrimester fetal liver characterized by dynamic transcriptomic and proteomic profiles. PLoS One. 2009;4(10):e7641
15J:15242 Halford S, Wilson DI, Daw SC, Roberts C, Wadey R, Kamath S, Wickremasinghe A, Burn J, Goodship J, Mattei MG, Moormon AF, Scambler PJ, Isolation of a gene expressed during early embryogenesis from the region of 22q11 commonly deleted in DiGeorge syndrome. Hum Mol Genet. 1993 Oct;2(10):1577-82
8J:173543 Harper J, Mould A, Andrews RM, Bikoff EK, Robertson EJ, The transcriptional repressor Blimp1/Prdm1 regulates postnatal reprogramming of intestinal enterocytes. Proc Natl Acad Sci U S A. 2011 Jun 28;108(26):10585-90
1J:77443 Hart AH, Hartley L, Sourris K, Stadler ES, Li R, Stanley EG, Tam PP, Elefanty AG, Robb L, Mixl1 is required for axial mesendoderm morphogenesis and patterning in the murine embryo. Development. 2002 Aug;129(15):3597-608
2J:87715 Hartner JC, Schmittwolf C, Kispert A, Muller AM, Higuchi M, Seeburg PH, Liver Disintegration in the Mouse Embryo Caused by Deficiency in the RNA-editing Enzyme ADAR1. J Biol Chem. 2004 Feb 6;279(6):4894-902
3*J:138863 Hayhurst GP, Strick-Marchand H, Mulet C, Richard AF, Morosan S, Kremsdorf D, Weiss MC, Morphogenetic competence of HNF4alpha-deficient mouse hepatic cells. J Hepatol. 2008 Sep;49(3):384-95
3*J:19957 Heller DL, Gianola KM, Leinwand LA, A highly conserved mouse gene with a propensity to form pseudogenes in mammals. Mol Cell Biol. 1988 Jul;8(7):2797-803
1J:31553 Hentsch B, Lyons I, Li R, Hartley L, Lints TJ, Adams JM, Harvey RP, Hlx homeo box gene is essential for an inductive tissue interaction that drives expansion of embryonic liver and gut. Genes Dev. 1996 Jan 1;10(1):70-9
1*J:139177 Hoffman BG, Zavaglia B, Witzsche J, Ruiz de Algara T, Beach M, Hoodless PA, Jones SJ, Marra MA, Helgason CD, Identification of transcripts with enriched expression in the developing and adult pancreas. Genome Biol. 2008;9(6):R99
1J:77517 Hong NA, Flannery M, Hsieh SN, Cado D, Pedersen R, Winoto A, Mice lacking Dad1, the defender against apoptotic death-1, express abnormal N-linked glycoproteins and undergo increased embryonic apoptosis. Dev Biol. 2000 Apr 1;220(1):76-84
2J:166089 Hosoya A, Kwak S, Kim EJ, Lunny DP, Lane EB, Cho SW, Jung HS, Immunohistochemical localization of cytokeratins in the junctional region of ectoderm and endoderm. Anat Rec (Hoboken). 2010 Nov;293(11):1864-72
1J:139642 Hou Y, Li F, Karin M, Ostrowski MC, Analysis of the IKKbeta/NF-kappaB signaling pathway during embryonic angiogenesis. Dev Dyn. 2008 Sep 24;237(10):2926-2935
5J:159513 Huang J, Bi Y, Zhu GH, He Y, Su Y, He BC, Wang Y, Kang Q, Chen L, Zuo GW, Luo Q, Shi Q, Zhang BQ, Huang A, Zhou L, Feng T, Luu HH, Haydon RC, He TC, Tang N, Retinoic acid signalling induces the differentiation of mouse fetal liver-derived hepatic progenitor cells. Liver Int. 2009 Nov;29(10):1569-81
1J:173801 Hudson QJ, Seidl CI, Kulinski TM, Huang R, Warczok KE, Bittner R, Bartolomei MS, Barlow DP, Extra-embryonic-specific imprinted expression is restricted to defined lineages in the post-implantation embryo. Dev Biol. 2011 May 15;353(2):420-31
6J:114852 Jiang F, Herman GE, Analysis of Nsdhl-deficient embryos reveals a role for Hedgehog signaling in early placental development. Hum Mol Genet. 2006 Nov 15;15(22):3293-305
3J:81475 Jochheim A, Cieslak A, Hillemann T, Cantz T, Scharf J, Manns MP, Ott M, Multi-stage analysis of differential gene expression in BALB/C mouse liver development by high-density microarrays. Differentiation. 2003 Jan;71(1):62-72
6*J:89458 Jochheim A, Hillemann T, Kania G, Scharf J, Attaran M, Manns MP, Wobus AM, Ott M, Quantitative gene expression profiling reveals a fetal hepatic phenotype of murine ES-derived hepatocytes. Int J Dev Biol. 2004 Feb;48(1):23-9
2J:108191 Jochheim-Richter A, Rudrich U, Koczan D, Hillemann T, Tewes S, Petry M, Kispert A, Sharma AD, Attaran F, Manns MP, Ott M, Gene expression analysis identifies novel genes participating in early murine liver development and adult liver regeneration. Differentiation. 2006 Apr;74(4):167-73
1J:71526 Jones EA, Clement-Jones M, James OF, Wilson DI, Differences between human and mouse alpha-fetoprotein expression during early development. J Anat. 2001 May;198(Pt 5):555-9
2*J:54660 Kamiya A, Kinoshita T, Ito Y, Matsui T, Morikawa Y, Senba E, Nakashima K, Taga T, Yoshida K, Kishimoto T, Miyajima A, Fetal liver development requires a paracrine action of oncostatin M through the gp130 signal transducer. EMBO J. 1999 Apr 15;18(8):2127-36
1*J:75946 Kanai-Azuma M, Kanai Y, Gad JM, Tajima Y, Taya C, Kurohmaru M, Sanai Y, Yonekawa H, Yazaki K, Tam PP, Hayashi Y, Depletion of definitive gut endoderm in Sox17-null mutant mice. Development. 2002 May;129(10):2367-79
1J:187732 Kawamura N, Sun-Wada GH, Aoyama M, Harada A, Takasuga S, Sasaki T, Wada Y, Delivery of endosomes to lysosomes via microautophagy in the visceral endoderm of mouse embryos. Nat Commun. 2012 Sep 18;3:1071
3J:65105 Keng VW, Yagi H, Ikawa M, Nagano T, Myint Z, Yamada K, Tanaka T, Sato A, Muramatsu I, Okabe M, Sato M, Noguchi T, Homeobox gene hex is essential for onset of mouse embryonic liver development and differentiation of the monocyte lineage. Biochem Biophys Res Commun. 2000 Oct 5;276(3):1155-61
3J:95098 Kodama Y, Hijikata M, Kageyama R, Shimotohno K, Chiba T, The role of notch signaling in the development of intrahepatic bile ducts. Gastroenterology. 2004 Dec;127(6):1775-86
2J:164800 Koike S, Keino-Masu K, Masu M, Deficiency of autotaxin/lysophospholipase D results in head cavity formation in mouse embryos through the LPA receptor-Rho-ROCK pathway. Biochem Biophys Res Commun. 2010 Sep 10;400(1):66-71
1J:55580 Komada M, Soriano P, Hrs, a FYVE finger protein localized to early endosomes, is implicated in vesicular traffic and required for ventral folding morphogenesis. Genes Dev. 1999 Jun 1;13(11):1475-85
1*J:14784 Kothary R, Perry MD, Moran LA, Rossant J, Cell-lineage-specific expression of the mouse hsp68 gene during embryogenesis. Dev Biol. 1987 Jun;121(2):342-8
1J:75520 Kovacs CS, Chafe LL, Woodland ML, McDonald KR, Fudge NJ, Wookey PJ, Calcitropic gene expression suggests a role for the intraplacental yolk sac in maternal-fetal calcium exchange. Am J Physiol Endocrinol Metab. 2002 Mar;282(3):E721-32
2J:40144 Kuo CT, Morrisey EE, Anandappa R, Sigrist K, Lu MM, Parmacek MS , Soudais C , Leiden JM, GATA4 transcription factor is required for ventral morphogenesis and heart tube formation. Genes Dev. 1997 Apr 15;11(8):1048-60
7J:111602 Kwon GS, Fraser ST, Eakin GS, Mangano M, Isern J, Sahr KE, Hadjantonakis AK, Baron MH, Tg(Afp-GFP) expression marks primitive and definitive endoderm lineages during mouse development. Dev Dyn. 2006 May 17;235(9):2549-2558
1J:143286 Kwon GS, Viotti M, Hadjantonakis AK, The endoderm of the mouse embryo arises by dynamic widespread intercalation of embryonic and extraembryonic lineages. Dev Cell. 2008 Oct;15(4):509-20
4J:17549 Law S, Tamoaki T, Kreuzaler F, Dugaiczyk A, Molecular cloning of DNA complementary to a mouse alpha-fetoprotein mRNA sequence. Gene. 1980 Jun;10(1):53-61
1J:19934 Law SW, Dugaiczyk A, Homology between the primary structure of alpha-fetoprotein, deduced from a complete cDNA sequence, and serum albumin. Nature. 1981 May 21;291(5812):201-5
2J:99346 Lee CS, Friedman JR, Fulmer JT, Kaestner KH, The initiation of liver development is dependent on Foxa transcription factors. Nature. 2005 Jun 16;435(7044):944-7
1J:155850 Lee D, Park C, Lee H, Lugus JJ, Kim SH, Arentson E, Chung YS, Gomez G, Kyba M, Lin S, Janknecht R, Lim DS, Choi K, ER71 acts downstream of BMP, Notch, and Wnt signaling in blood and vessel progenitor specification. Cell Stem Cell. 2008 May 8;2(5):497-507
3J:181881 Lee JS, Ward WO, Knapp G, Ren H, Vallanat B, Abbott B, Ho K, Karp SJ, Corton JC, Transcriptional ontogeny of the developing liver. BMC Genomics. 2012;13:33
9J:146970 Li T, Huang J, Jiang Y, Zeng Y, He F, Zhang MQ, Han Z, Zhang X, Multi-stage analysis of gene expression and transcription regulation in C57/B6 mouse liver development. Genomics. 2009 Mar;93(3):235-42
1*J:77742 Lin X, Jung J, Kang D, Xu B, Zaret KS, Zoghbi H, Prenylcysteine carboxylmethyltransferase is essential for the earliest stages of liver development in mice. Gastroenterology. 2002 Jul;123(1):345-51
3J:106308 Liu Y, Festing M, Thompson JC, Hester M, Rankin S, El-Hodiri HM, Zorn AM, Weinstein M, Smad2 and Smad3 coordinately regulate craniofacial and endodermal development. Dev Biol. 2004 Jun 15;270(2):411-26
3J:139252 Lokmane L, Haumaitre C, Garcia-Villalba P, Anselme I, Schneider-Maunoury S, Cereghini S, Crucial role of vHNF1 in vertebrate hepatic specification. Development. 2008 Aug;135(16):2777-86
2*J:94197 Long L, Spear BT, FoxA proteins regulate H19 endoderm enhancer E1 and exhibit developmental changes in enhancer binding in vivo. Mol Cell Biol. 2004 Nov;24(21):9601-9
1*J:103128 Machka C, Kersten M, Zobawa M, Harder A, Horsch M, Halder T, Lottspeich F, Hrabe de Angelis M, Beckers J, Identification of Dll1 (Delta1) target genes during mouse embryogenesis using differential expression profiling. Gene Expr Patterns. 2005 Dec;6(1):94-101
1J:136719 Maretto S, Muller PS, Aricescu AR, Cho KW, Bikoff EK, Robertson EJ, Ventral closure, headfold fusion and definitive endoderm migration defects in mouse embryos lacking the fibronectin leucine-rich transmembrane protein FLRT3. Dev Biol. 2008 Jun 1;318(1):184-93
2*J:38354 Marhaug G, Hackett B, Dowton SB, Serum amyloid A gene expression in rabbit, mink and mouse. Clin Exp Immunol. 1997 Feb;107(2):425-34
5J:87367 Martin CM, Meeson AP, Robertson SM, Hawke TJ, Richardson JA, Bates S, Goetsch SC, Gallardo TD, Garry DJ, Persistent expression of the ATP-binding cassette transporter, Abcg2, identifies cardiac SP cells in the developing and adult heart. Dev Biol. 2004 Jan 1;265(1):262-75
2J:62027 Martinez Barbera JP, Clements M, Thomas P, Rodriguez T, Meloy D, Kioussis D, Beddington RS, The homeobox gene Hex is required in definitive endodermal tissues for normal forebrain, liver and thyroid formation. Development. 2000 Jun;127(11):2433-45
3J:170660 Matsuo A, Yoshida T, Yasukawa T, Miki R, Kume K, Kume S, Epiplakin1 is expressed in the cholangiocyte lineage cells in normal liver and adult progenitor cells in injured liver. Gene Expr Patterns. 2011 Mar-Apr;11(3-4):255-62
1*J:57676 McGrath KE, Koniski AD, Maltby KM, McGann JK, Palis J, Embryonic expression and function of the chemokine SDF-1 and its receptor, CXCR4. Dev Biol. 1999 Sep 15;213(2):442-56
4J:157265 McKnight KD, Hou J, Hoodless PA, Foxh1 and Foxa2 are not required for formation of the midgut and hindgut definitive endoderm. Dev Biol. 2010 Jan 15;337(2):471-81
3J:92091 Micsenyi A, Tan X, Sneddon T, Luo JH, Michalopoulos GK, Monga SP, Beta-catenin is temporally regulated during normal liver development. Gastroenterology. 2004 Apr;126(4):1134-46
3J:185124 Misra C, Sachan N, McNally CR, Koenig SN, Nichols HA, Guggilam A, Lucchesi PA, Pu WT, Srivastava D, Garg V, Congenital heart disease-causing Gata4 mutation displays functional deficits in vivo. PLoS Genet. 2012 May;8(5):e1002690
4J:40145 Molkentin JD, Lin Q, Duncan SA, Olson EN, Requirement of the transcription factor GATA4 for heart tube formation and ventral morphogenesis. Genes Dev. 1997 APR 15;11(8):1061-1072
1*J:87222 Morkel M, Huelsken J, Wakamiya M, Ding J, van de Wetering M, Clevers H, Taketo MM, Behringer RR, Shen MM, Birchmeier W, Beta-catenin regulates Cripto- and Wnt3-dependent gene expression programs in mouse axis and mesoderm formation. Development. 2003 Dec;130(25):6283-94
1J:163858 Morsut L, Yan KP, Enzo E, Aragona M, Soligo SM, Wendling O, Mark M, Khetchoumian K, Bressan G, Chambon P, Dupont S, Losson R, Piccolo S, Negative control of Smad activity by ectodermin/Tif1gamma patterns the mammalian embryo. Development. 2010 Aug 1;137(15):2571-8
2J:7235 Muller R, Verma IM, Adamson ED, Expression of c-onc genes: c-fos transcripts accumulate to high levels during development of mouse placenta, yolk sac and amnion. EMBO J. 1983;2(5):679-84
3*J:154021 Naidu S, Peterson ML, Spear BT, Alpha-fetoprotein related gene (ARG): a new member of the albumin gene family that is no longer functional in primates. Gene. 2010 Jan 1;449(1-2):95-102
1J:67042 Nitou M, Ishikawa K, Shiojiri N, Immunohistochemical analysis of development of desmin-positive hepatic stellate cells in mouse liver. J Anat. 2000 Nov;197 Pt 4:635-46
1J:155001 Oh S, Lee D, Kim T, Kim TS, Oh HJ, Hwang CY, Kong YY, Kwon KS, Lim DS, Crucial role for Mst1 and Mst2 kinases in early embryonic development of the mouse. Mol Cell Biol. 2009 Dec;29(23):6309-20
1J:163653 Ohazama A, Haworth KE, Ota MS, Khonsari RH, Sharpe PT, Ectoderm, endoderm, and the evolution of heterodont dentitions. Genesis. 2010 Jun;48(6):382-9
1J:146853 Oikawa T, Kamiya A, Kakinuma S, Zeniya M, Nishinakamura R, Tajiri H, Nakauchi H, Sall4 regulates cell fate decision in fetal hepatic stem/progenitor cells. Gastroenterology. 2009 Mar;136(3):1000-11
2*J:1977 Ott MO, Rey-Campos J, Cereghini S, Yaniv M, vHNF1 is expressed in epithelial cells of distinct embryonic origin during development and precedes HNF1 expression. Mech Dev. 1991 Dec;36(1-2):47-58
2J:7571 Pachnis V, Belayew A, Tilghman SM, Locus unlinked to alpha-fetoprotein under the control of the murine raf and Rif genes. Proc Natl Acad Sci U S A. 1984 Sep;81(17):5523-7
1J:28424 Palis J, Kingsley PD, Differential gene expression during early murine yolk sac development. Mol Reprod Dev. 1995 Sep;42(1):19-27
1J:42759 Panning B, Dausman J, Jaenisch R, X chromosome inactivation is mediated by Xist RNA stabilization. Cell. 1997 Sep 5;90(5):907-16
1*J:185112 Park D, Choi D, Lee J, Lim DS, Park C, Male-like sexual behavior of female mouse lacking fucose mutarotase. BMC Genet. 2010;11:62
1*J:170493 Pfister S, Jones VJ, Power M, Truisi GL, Khoo PL, Steiner KA, Kanai-Azuma M, Kanai Y, Tam PP, Loebel DA, Sox17-dependent gene expression and early heart and gut development in Sox17-deficient mouse embryos. Int J Dev Biol. 2011;55(1):45-58
1J:205747 Polydorou C, Georgiades P, Ets2-dependent trophoblast signalling is required for gastrulation progression after primitive streak initiation. Nat Commun. 2013;4:1658
1*J:76367 Rathjen J, Haines BP, Hudson KM, Nesci A, Dunn S, Rathjen PD, Directed differentiation of pluripotent cells to neural lineages: homogeneous formation and differentiation of a neurectoderm population. Development. 2002 Jun;129(11):2649-61
2J:59916 Reimold AM, Etkin A, Clauss I, Perkins A, Friend DS, Zhang J, Horton HF, Scott A, Orkin SH, Byrne MC, Grusby MJ, Glimcher LH, An essential role in liver development for transcription factor XBP-1. Genes Dev. 2000 Jan 15;14(2):152-7
1J:37149 Richards WG, Yoder BK, Isfort RJ, Detilleux PG, Foster C, Neilsen N , Woychik RP , Wilkinson JE, Oval cell proliferation associated with the murine insertional mutation TgN737Rpw. Am J Pathol. 1996 Dec;149(6):1919-30
1*J:27458 Robb L, Lyons I, Li R, Hartley L, Kontgen F, Harvey RP, Metcalf D, Begley CG, Absence of yolk sac hematopoiesis from mice with a targeted disruption of the scl gene. Proc Natl Acad Sci U S A. 1995 Jul 18;92(15):7075-9
6J:180846 Saito K, Ogawa A, Toyofuku K, Hosoi Y, Soma M, Iha M, Kasuga K, Kojima I, Kobayashi M, Relationships between homeoprotein EGAM1C and the expression of the placental prolactin gene family in mouse placentae and trophoblast stem cells. Reproduction. 2011 Feb;141(2):259-68
1J:131426 Sawada A, Kiyonari H, Ukita K, Nishioka N, Imuta Y, Sasaki H, Redundant roles of Tead1 and Tead2 in notochord development and the regulation of cell proliferation and survival. Mol Cell Biol. 2008 May;28(10):3177-89
12J:187541 Schievenbusch S, Sauer E, Curth HM, Schulte S, Demir M, Toex U, Goeser T, Nierhoff D, Neighbor of punc e 11: expression pattern of the new hepatic stem/progenitor cell marker during murine liver development. Stem Cells Dev. 2012 Sep 20;21(14):2656-66
1J:31180 Schmid P, Cox D, Bilbe G, Maier R, McMaster GK, Differential expression of TGF beta 1, beta 2 and beta 3 genes during mouse embryogenesis. Development. 1991 Jan;111(1):117-30
6J:65026 Scohy S, Gabant P, Szpirer C, Szpirer J, Identification of an enhancer and an alternative promoter in the first intron of the alpha-fetoprotein gene. Nucleic Acids Res. 2000 Oct 1;28(19):3743-51
4J:187729 Seymour PA, Shih HP, Patel NA, Freude KK, Xie R, Lim CJ, Sander M, A Sox9/Fgf feed-forward loop maintains pancreatic organ identity. Development. 2012 Sep;139(18):3363-72
2J:118123 Shen J, Liu J, Xie Y, Diwan BA, Waalkes MP, Fetal onset of aberrant gene expression relevant to pulmonary carcinogenesis in lung adenocarcinoma development induced by in utero arsenic exposure. Toxicol Sci. 2007 Feb;95(2):313-20
2J:168015 Shibata M, Garcia-Garcia MJ, The mouse KRAB zinc-finger protein CHATO is required in embryonic-derived tissues to control yolk sac and placenta morphogenesis. Dev Biol. 2011 Jan 15;349(2):331-41
1J:82844 Shimono A, Behringer RR, Angiomotin Regulates Visceral Endoderm Movements during Mouse Embryogenesis. Curr Biol. 2003 Apr 1;13(7):613-7
1J:20728 Shiojiri N, Transient expression of bile-duct-specific cytokeratin in fetal mouse hepatocytes. Cell Tissue Res. 1994 Oct;278(1):117-23
5J:95079 Shiojiri N, Takeshita K, Yamasaki H, Iwata T, Suppression of C/EBP alpha expression in biliary cell differentiation from hepatoblasts during mouse liver development. J Hepatol. 2004 Nov;41(5):790-8
1*J:23061 Shivdasani RA, Mayer EL, Orkin SH, Absence of blood formation in mice lacking the T-cell leukaemia oncoprotein tal-1/SCL. Nature. 1995 Feb 2;373(6513):432-4
2J:7325 Simpson E, McLaren A, Chandler P, Tomonari K, Expression of H-Y antigen by female mice carrying Sxr. Transplantation. 1984 Jan;37(1):17-21
12J:178367 Slamon DJ, Cline MJ, Expression of cellular oncogenes during embryonic and fetal development of the mouse. Proc Natl Acad Sci U S A. 1984 Nov;81(22):7141-5
1J:156541 Song H, Mak KK, Topol L, Yun K, Hu J, Garrett L, Chen Y, Park O, Chang J, Simpson RM, Wang CY, Gao B, Jiang J, Yang Y, Mammalian Mst1 and Mst2 kinases play essential roles in organ size control and tumor suppression. Proc Natl Acad Sci U S A. 2010 Jan 8;
3J:63128 Sosa-Pineda B, Wigle JT, Oliver G, Hepatocyte migration during liver development requires Prox1. Nat Genet. 2000 Jul;25(3):254-5
1*J:20408 Spear BT, Mouse alpha-fetoprotein gene 5' regulatory elements are required for postnatal regulation by raf and Rif. Mol Cell Biol. 1994 Oct;14(10):6497-505
1J:144999 Su H, Trombly MI, Chen J, Wang X, Essential and overlapping functions for mammalian Argonautes in microRNA silencing. Genes Dev. 2009 Feb 1;23(3):304-17
1J:134487 Suzuki A, Sekiya S, Buscher D, Izpisua Belmonte JC, Taniguchi H, Tbx3 controls the fate of hepatic progenitor cells in liver development by suppressing p19ARF expression. Development. 2008 May;135(9):1589-95
4J:103404 Tan EH, Hooi SC, Laban M, Wong E, Ponniah S, Wee A, Wang ND, CCAAT/enhancer binding protein alpha knock-in mice exhibit early liver glycogen storage and reduced susceptibility to hepatocellular carcinoma. Cancer Res. 2005 Nov 15;65(22):10330-7
1J:81747 Tang Y, Katuri V, Dillner A, Mishra B, Deng CX, Mishra L, Disruption of transforming growth factor-beta signaling in ELF beta-spectrin-deficient mice. Science. 2003 Jan 24;299(5606):574-7
1J:196073 Tasaki T, Kim ST, Zakrzewska A, Lee BE, Kang MJ, Yoo YD, Cha-Molstad HJ, Hwang J, Soung NK, Sung KS, Kim SH, Nguyen MD, Sun M, Yi EC, Kim BY, Kwon YT, UBR box N-recognin-4 (UBR4), an N-recognin of the N-end rule pathway, and its role in yolk sac vascular development and autophagy. Proc Natl Acad Sci U S A. 2013 Mar 5;110(10):3800-5
2J:138818 Tatarakis A, Margaritis T, Martinez-Jimenez CP, Kouskouti A, Mohan WS 2nd, Haroniti A, Kafetzopoulos D, Tora L, Talianidis I, Dominant and redundant functions of TFIID involved in the regulation of hepatic genes. Mol Cell. 2008 Aug 22;31(4):531-43
2*J:23790 Tharun S, Sirdeshmukh R, Specific endonucleolytic cleavages of mouse albumin mRNA and their modulation during liver development. Nucleic Acids Res. 1995 Feb 25;23(4):641-6
3J:31563 Tilghman SM, Kioussis D, Gorin MB, Ruiz JP, Ingram RS, The presence of intervening sequences in the alpha-fetoprotein gene of the mouse. J Biol Chem. 1979 Aug 10;254(15):7393-9
2J:137798 Tomizawa M, Toyama Y, Ito C, Toshimori K, Iwase K, Takiguchi M, Saisho H, Yokosuka O, Hepatoblast-like cells enriched from mouse embryonic stem cells in medium without glucose, pyruvate, arginine, and tyrosine. Cell Tissue Res. 2008 Jul;333(1):17-27
2*J:73291 Torres-Padilla ME, Fougere-Deschatrette C, Weiss MC, Expression of HNF4alpha isoforms in mouse liver development is regulated by sequential promoter usage and constitutive 3' end splicing. Mech Dev. 2001 Dec;109(2):183-93
2*J:71998 Tremblay KD, Dunn NR, Robertson EJ, Mouse embryos lacking Smad1 signals display defects in extra-embryonic tissues and germ cell formation. Development. 2001 Sep;128(18):3609-21
4J:30022 Trojan J, Naval X, Johnson T, Lafarge-Frayssinet C, Hajeri-Germond M, Farges O, Pan Y, Uriel J, Abramasky O, Ilan J, Expression of serum albumin and of alphafetoprotein in murine normal and neoplastic primitive embryonic structures. Mol Reprod Dev. 1995 Dec;42(4):369-78
1*J:9912 Vaessen MJ, Kootwijk E, Mummery C, Hilkens J, Bootsma D, van Kessel AG, Preferential expression of cellular retinoic acid binding protein in a subpopulation of neural cells in the developing mouse embryo. Differentiation. 1989 May;40(2):99-105
1J:46532 Waldrip WR, Bikoff EK, Hoodless PA, Wrana JL, Robertson EJ, Smad2 signaling in extraembryonic tissues determines anterior-posterior polarity of the early mouse embryo. Cell. 1998 Mar 20;92(6):797-808
3J:146397 Wanderling S, Simen BB, Ostrovsky O, Ahmed NT, Vogen SM, Gidalevitz T, Argon Y, GRP94 is essential for mesoderm induction and muscle development because it regulates insulin-like growth factor secretion. Mol Biol Cell. 2007 Oct;18(10):3764-75
1J:94468 Wandzioch E, Kolterud A, Jacobsson M, Friedman SL, Carlsson L, Lhx2-/- mice develop liver fibrosis. Proc Natl Acad Sci U S A. 2004 Nov 23;101(47):16549-54
1J:149963 Wandzioch E, Zaret KS, Dynamic signaling network for the specification of embryonic pancreas and liver progenitors. Science. 2009 Jun 26;324(5935):1707-10
2J:79547 Watanabe T, Nakagawa K, Ohata S, Kitagawa D, Nishitai G, Seo J, Tanemura S, Shimizu N, Kishimoto H, Wada T, Aoki J, Arai H, Iwatsubo T, Mochita M, Watanabe T, Satake M, Ito Y, Matsuyama T, Mak T, Penninger J, Nishina H, Katada T, SEK1/MKK4-Mediated SAPK/JNK Signaling Participates in Embryonic Hepatoblast Proliferation via a Pathway Different from NF-kappaB-Induced Anti-Apoptosis. Dev Biol. 2002 Oct 15;250(2):332
1*J:67263 Watt AJ, Jones EA, Ure JM, Peddie D, Wilson DI, Forrester LM, A gene trap integration provides an early in situ marker for hepatic specification of the foregut endoderm. Mech Dev. 2001 Feb;100(2):205-15
1J:70388 Weinstein M, Monga SP, Liu Y, Brodie SG, Tang Y, Li C, Mishra L, Deng CX, Smad proteins and hepatocyte growth factor control parallel regulatory pathways that converge on beta1-integrin to promote normal liver development. Mol Cell Biol. 2001 Aug;21(15):5122-31
3J:111705 Westmacott A, Burke ZD, Oliver G, Slack JM, Tosh D, C/EBPalpha and C/EBPbeta are markers of early liver development. Int J Dev Biol. 2006;50(7):653-7
1J:103454 Woda JM, Calzonetti T, Hilditch-Maguire P, Duyao MP, Conlon RA, MacDonald ME, Inactivation of the Huntington's disease gene (Hdh) impairs anterior streak formation and early patterning of the mouse embryo. BMC Dev Biol. 2005 Aug 18;5:17
8J:140053 Xie Z, Zhang H, Tsai W, Zhang Y, Du Y, Zhong J, Szpirer C, Zhu M, Cao X, Barton MC, Grusby MJ, Zhang WJ, Zinc finger protein ZBTB20 is a key repressor of alpha-fetoprotein gene transcription in liver. Proc Natl Acad Sci U S A. 2008 Aug 5;105(31):10859-64
1*J:51595 Xu C, Liguori G, Persico MG, Adamson ED, Abrogation of the Cripto gene in mouse leads to failure of postgastrulation morphogenesis and lack of differentiation of cardiomyocytes. Development. 1999 Feb;126(3):483-94
2J:172635 Xu CR, Cole PA, Meyers DJ, Kormish J, Dent S, Zaret KS, Chromatin 'prepattern' and histone modifiers in a fate choice for liver and pancreas. Science. 2011 May 20;332(6032):963-6
1J:147036 Yamashita R, Takegawa Y, Sakumoto M, Nakahara M, Kawazu H, Hoshii T, Araki K, Yokouchi Y, Yamamura K, Defective development of the gall bladder and cystic duct in Lgr4- hypomorphic mice. Dev Dyn. 2009 Apr;238(4):993-1000
1J:97579 Zhao R, Watt AJ, Li J, Luebke-Wheeler J, Morrisey EE, Duncan SA, GATA6 is essential for embryonic development of the liver but dispensable for early heart formation. Mol Cell Biol. 2005 Apr;25(7):2622-31
1J:63719 Zwijsen A, van Rooijen MA, Goumans MJ, Dewulf N, Bosman EA, ten Dijke P, Mummery CL, Huylebroeck D, Expression of the inhibitory Smad7 in early mouse development and upregulation during embryonic vasculogenesis. Dev Dyn. 2000 Aug;218(4):663-70

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