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Gene Expression Literature Summary
Symbol
Name
ID
Robo2
roundabout homolog 2 (Drosophila)
MGI:1890110

81 matching records from 81 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.
Age E4.5 E5.5 E7 E8.5 E9.5 E10 E10.5 E11 E11.5 E12 E12.5 E13 E13.5 E14 E14.5 E15 E15.5 E16 E16.5 E17 E17.5 E18 E18.5 E A
In situ protein (section) 1 1 1 3 1 2 1 5 1 8 4 5 1 5 1 7 1 1 2 4 1 7
In situ RNA (section) 1 1 3 1 5 1 8 3 12 2 11 2 8 2 7 2 5 1 4 2 7
In situ protein (whole mount) 1 1 1
In situ RNA (whole mount) 1 3 1 4 2 2 1 1 1 1 1 1 1 1 1
In situ reporter (knock in) 1 1 1 2 1 2 1
Northern blot 1 1 1 1 2 1 1 1 1 1 1 2
RT-PCR 1 3 3 1 2 1 2 3
cDNA clones 1 1 1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available
Robo2  roundabout homolog 2 (Drosophila)   (Synonyms: 2600013A04Rik, 9430089E08Rik, D230004I22Rik, mKIAA1568)
Results  Reference
3J:130430 Andrews W, Barber M, Hernadez-Miranda LR, Xian J, Rakic S, Sundaresan V, Rabbitts TH, Pannell R, Rabbitts P, Thompson H, Erskine L, Murakami F, Parnavelas JG, The role of Slit-Robo signaling in the generation, migration and morphological differentiation of cortical interneurons. Dev Biol. 2008 Jan 15;313(2):648-58
2J:109478 Andrews W, Liapi A, Plachez C, Camurri L, Zhang J, Mori S, Murakami F, Parnavelas JG, Sundaresan V, Richards LJ, Robo1 regulates the development of major axon tracts and interneuron migration in the forebrain. Development. 2006 Jun;133(11):2243-52
12*J:82500 Anselmo MA, Dalvin S, Prodhan P, Komatsuzaki K, Aidlen JT, Schnitzer JJ, Wu JY, Bernard Kinane T, Slit and robo: expression patterns in lung development. Gene Expr Patterns. 2003 Mar;3(1):13-9
1J:107695 Bagri A, Marin O, Plump AS, Mak J, Pleasure SJ, Rubenstein JL, Tessier-Lavigne M, Slit proteins prevent midline crossing and determine the dorsoventral position of major axonal pathways in the mammalian forebrain. Neuron. 2002 Jan 17;33(2):233-48
3J:148786 Barber M, Di Meglio T, Andrews WD, Hernandez-Miranda LR, Murakami F, Chedotal A, Parnavelas JG, The Role of Robo3 in the Development of Cortical Interneurons. Cereb Cortex. 2009 Apr 14;
1J:174731 Bielle F, Marcos-Mondejar P, Keita M, Mailhes C, Verney C, Nguyen Ba-Charvet K, Tessier-Lavigne M, Lopez-Bendito G, Garel S, Slit2 activity in the migration of guidepost neurons shapes thalamic projections during development and evolution. Neuron. 2011 Mar 24;69(6):1085-98
2J:182736 Bravo-Ambrosio A, Mastick G, Kaprielian Z, Motor axon exit from the mammalian spinal cord is controlled by the homeodomain protein Nkx2.9 via Robo-Slit signaling. Development. 2012 Apr;139(8):1435-46
2*J:87380 Camurri L, Mambetisaeva E, Sundaresan V, Rig-1 a new member of Robo family genes exhibits distinct pattern of expression during mouse development. Gene Expr Patterns. 2004 Jan;4(1):99-103
2J:77261 Causeret F, Danne F, Ezan F, Sotelo C, Bloch-Gallego E, Slit antagonizes netrin-1 attractive effects during the migration of inferior olivary neurons. Dev Biol. 2002 Jun 15;246(2):429-40
1J:73073 Chapouton P, Schuurmans C, Guillemot F, Gotz M, The transcription factor neurogenin 2 restricts cell migration from the cortex to the striatum. Development. 2001 Dec;128(24):5149-59
3J:189961 Chatterjee M, Li K, Chen L, Maisano X, Guo Q, Gan L, Li JY, Gbx2 regulates thalamocortical axon guidance by modifying the LIM and Robo codes. Development. 2012 Dec;139(24):4633-43
4J:103829 Chen B, Schaevitz LR, McConnell SK, Fezl regulates the differentiation and axon targeting of layer 5 subcortical projection neurons in cerebral cortex. Proc Natl Acad Sci U S A. 2005 Nov 22;102(47):17184-9
2J:190657 Cho JH, Kam JW, Cloutier JF, Slits and Robo-2 regulate the coalescence of subsets of olfactory sensory neuron axons within the ventral region of the olfactory bulb. Dev Biol. 2012 Nov 15;371(2):269-79
4J:173325 Cho JH, Prince JE, Cutforth T, Cloutier JF, The pattern of glomerular map formation defines responsiveness to aversive odorants in mice. J Neurosci. 2011 May 25;31(21):7920-6
1J:198412 Colak D, Ji SJ, Porse BT, Jaffrey SR, Regulation of axon guidance by compartmentalized nonsense-mediated mRNA decay. Cell. 2013 Jun 6;153(6):1252-65
2J:169370 Conway CD, Howe KM, Nettleton NK, Price DJ, Mason JO, Pratt T, Heparan sulfate sugar modifications mediate the functions of slits and other factors needed for mouse forebrain commissure development. J Neurosci. 2011 Feb 9;31(6):1955-70
1J:185743 Cotney J, Leng J, Oh S, DeMare LE, Reilly SK, Gerstein MB, Noonan JP, Chromatin state signatures associated with tissue-specific gene expression and enhancer activity in the embryonic limb. Genome Res. 2012 Jun;22(6):1069-80
3J:137616 Di Meglio T, Nguyen-Ba-Charvet KT, Tessier-Lavigne M, Sotelo C, Chedotal A, Molecular mechanisms controlling midline crossing by precerebellar neurons. J Neurosci. 2008 Jun 18;28(25):6285-94
1J:92064 Ding YQ, Yin J, Kania A, Zhao ZQ, Johnson RL, Chen ZF, Lmx1b controls the differentiation and migration of the superficial dorsal horn neurons of the spinal cord. Development. 2004 Aug;131(15):3693-703
5J:193400 Domyan ET, Branchfield K, Gibson DA, Naiche LA, Lewandoski M, Tessier-Lavigne M, Ma L, Sun X, Roundabout receptors are critical for foregut separation from the body wall. Dev Cell. 2013 Jan 14;24(1):52-63
2J:171296 Dugan JP, Stratton A, Riley HP, Farmer WT, Mastick GS, Midbrain dopaminergic axons are guided longitudinally through the diencephalon by Slit/Robo signals. Mol Cell Neurosci. 2011 Jan;46(1):347-56
2J:196080 Elsen GE, Hodge RD, Bedogni F, Daza RA, Nelson BR, Shiba N, Reiner SL, Hevner RF, The protomap is propagated to cortical plate neurons through an Eomes-dependent intermediate map. Proc Natl Acad Sci U S A. 2013 Mar 5;110(10):4081-6
4J:63172 Erskine L, Williams SE, Brose K, Kidd T, Rachel RA, Goodman CS, Tessier-Lavigne M, Mason CA, Retinal ganglion cell axon guidance in the mouse optic chiasm: expression and function of robos and slits. J Neurosci. 2000 Jul 1;20(13):4975-82
5J:196018 Fan X, Li Q, Pisarek-Horowitz A, Rasouly HM, Wang X, Bonegio RG, Wang H, McLaughlin M, Mangos S, Kalluri R, Holzman LB, Drummond IA, Brown D, Salant DJ, Lu W, Inhibitory effects of Robo2 on nephrin: a crosstalk between positive and negative signals regulating podocyte structure. Cell Rep. 2012 Jul 26;2(1):52-61
2J:143413 Farmer WT, Altick AL, Nural HF, Dugan JP, Kidd T, Charron F, Mastick GS, Pioneer longitudinal axons navigate using floor plate and Slit/Robo signals. Development. 2008 Nov;135(22):3643-53
3J:119469 Fouquet C, Di Meglio T, Ma L, Kawasaki T, Long H, Hirata T, Tessier-Lavigne M, Chedotal A, Nguyen-Ba-Charvet KT, Robo1 and robo2 control the development of the lateral olfactory tract. J Neurosci. 2007 Mar 14;27(11):3037-45
2J:139385 Geisen MJ, Di Meglio T, Pasqualetti M, Ducret S, Brunet JF, Chedotal A, Rijli FM, Hox paralog group 2 genes control the migration of mouse pontine neurons through slit-robo signaling. PLoS Biol. 2008 Jun 10;6(6):e142
5J:192337 Goldberg D, Borojevic R, Anderson M, Chen JJ, Gershon MD, Ratcliffe EM, Slit/Robo-mediated chemorepulsion of vagal sensory axons in the fetal gut. Dev Dyn. 2013 Jan;242(1):9-15
8J:90281 Greenberg JM, Thompson FY, Brooks SK, Shannon JM, Akeson AL, Slit and robo expression in the developing mouse lung. Dev Dyn. 2004 Jun;230(2):350-60
3J:90324 Grieshammer U, Le Ma, Plump AS, Wang F, Tessier-Lavigne M, Martin GR, SLIT2-mediated ROBO2 signaling restricts kidney induction to a single site. Dev Cell. 2004 May;6(5):709-17
1*J:171409 GUDMAP Consortium, GUDMAP: the GenitoUrinary Development Molecular Anatomy Project. http://www.gudmap.org. 2004;
1J:142864 Hains D, Sims-Lucas S, Kish K, Saha M, McHugh K, Bates CM, Role of fibroblast growth factor receptor 2 in kidney mesenchyme. Pediatr Res. 2008 Dec;64(6):592-8
1J:94593 Inaki K, Nishimura S, Nakashiba T, Itohara S, Yoshihara Y, Laminar organization of the developing lateral olfactory tract revealed by differential expression of cell recognition molecules. J Comp Neurol. 2004 Nov 15;479(3):243-56
1J:162558 Jaworski A, Long H, Tessier-Lavigne M, Collaborative and specialized functions of Robo1 and Robo2 in spinal commissural axon guidance. J Neurosci. 2010 Jul 14;30(28):9445-53
3*J:102103 Jensen P, Magdaleno S, Lehman KM, Rice DS, Lavallie ER, Collins-Racie L, McCoy JM, Curran T, A neurogenomics approach to gene expression analysis in the developing brain. Brain Res Mol Brain Res. 2004 Dec 20;132(2):116-27
2J:65749 Jimenez D, Garcia C, de Castro F, Chedotal A, Sotelo C, de Carlos JA, Valverde F, Lopez-Mascaraque L, Evidence for intrinsic development of olfactory structures in Pax-6 mutant mice. J Comp Neurol. 2000 Dec 18;428(3):511-26
2J:85869 Jimenez D, Lopez-Mascaraque L, De Carlos JA, Valverde F, Further studies on cortical tangential migration in wild type and Pax-6 mutant mice. J Neurocytol. 2002 Sep-Oct;31(8-9):719-28
1J:133680 Jones CA, London NR, Chen H, Park KW, Sauvaget D, Stockton RA, Wythe JD, Suh W, Larrieu-Lahargue F, Mukouyama YS, Lindblom P, Seth P, Frias A, Nishiya N, Ginsberg MH, Gerhardt H, Zhang K, Li DY, Robo4 stabilizes the vascular network by inhibiting pathologic angiogenesis and endothelial hyperpermeability. Nat Med. 2008 Apr;14(4):448-53
2J:119301 Kadison SR, Murakami F, Matise MP, Kaprielian Z, The role of floor plate contact in the elaboration of contralateral commissural projections within the embryonic mouse spinal cord. Dev Biol. 2006 Aug 15;296(2):499-513
3J:176600 Kim M, Roesener AP, Mendonca PR, Mastick GS, Robo1 and Robo2 have distinct roles in pioneer longitudinal axon guidance. Dev Biol. 2011 Oct 1;358(1):181-8
3J:86040 Knoll B, Schmidt H, Andrews W, Guthrie S, Pini A, Sundaresan V, Drescher U, On the topographic targeting of basal vomeronasal axons through Slit-mediated chemorepulsion. Development. 2003 Nov;130(21):5073-82
1J:163240 Kuwako K, Kakumoto K, Imai T, Igarashi M, Hamakubo T, Sakakibara S, Tessier-Lavigne M, Okano HJ, Okano H, Neural RNA-binding protein Musashi1 controls midline crossing of precerebellar neurons through posttranscriptional regulation of Robo3/Rig-1 expression. Neuron. 2010 Aug 12;67(3):407-21
1J:109564 Li MZ, Wang JS, Jiang DJ, Xiang CX, Wang FY, Zhang KH, Williams PR, Chen ZF, Molecular mapping of developing dorsal horn-enriched genes by microarray and dorsal/ventral subtractive screening. Dev Biol. 2006 Apr 15;292(2):555-64
7*J:71421 Loes S, Luukko K, Kvinnsland IH, Kettunen P, Slit1 is specifically expressed in the primary and secondary enamel knots during molar tooth cusp formation. Mech Dev. 2001 Sep;107(1-2):155-7
1J:89780 Long H, Sabatier C, Ma L, Plump A, Yuan W, Ornitz DM, Tamada A, Murakami F, Goodman CS, Tessier-Lavigne M, Conserved roles for Slit and Robo proteins in midline commissural axon guidance. Neuron. 2004 Apr 22;42(2):213-23
1J:173286 Long JE, Cobos I, Potter GB, Rubenstein JL, Dlx1&2 and Mash1 transcription factors control MGE and CGE patterning and differentiation through parallel and overlapping pathways. Cereb Cortex. 2009 Jul;19 Suppl 1:i96-106
2J:119448 Long JE, Garel S, Alvarez-Dolado M, Yoshikawa K, Osumi N, Alvarez-Buylla A, Rubenstein JL, Dlx-dependent and -independent regulation of olfactory bulb interneuron differentiation. J Neurosci. 2007 Mar 21;27(12):3230-43
1J:173287 Long JE, Swan C, Liang WS, Cobos I, Potter GB, Rubenstein JL, Dlx1&2 and Mash1 transcription factors control striatal patterning and differentiation through parallel and overlapping pathways. J Comp Neurol. 2009 Feb 1;512(4):556-72
5J:120131 Lopez-Bendito G, Flames N, Ma L, Fouquet C, Di Meglio T, Chedotal A, Tessier-Lavigne M, Marin O, Robo1 and Robo2 cooperate to control the guidance of major axonal tracts in the mammalian forebrain. J Neurosci. 2007 Mar 28;27(13):3395-407
3*J:162220 Magdaleno S, Jensen P, Brumwell CL, Seal A, Lehman K, Asbury A, Cheung T, Cornelius T, Batten DM, Eden C, Norland SM, Rice DS, Dosooye N, Shakya S, Mehta P, Curran T, BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. PLoS Biol. 2006 Apr;4(4):e86
1J:183861 Marcos-Mondejar P, Peregrin S, Li JY, Carlsson L, Tole S, Lopez-Bendito G, The lhx2 transcription factor controls thalamocortical axonal guidance by specific regulation of robo1 and robo2 receptors. J Neurosci. 2012 Mar 28;32(13):4372-85
1J:91469 Marillat V, Sabatier C, Failli V, Matsunaga E, Sotelo C, Tessier-Lavigne M, Chedotal A, The slit receptor Rig-1/Robo3 controls midline crossing by hindbrain precerebellar neurons and axons. Neuron. 2004 Jul 8;43(1):69-79
1*J:74238 Marin O, Baker J, Puelles L, Rubenstein JL, Patterning of the basal telencephalon and hypothalamus is essential for guidance of cortical projections. Development. 2002 Feb 1;129(3):761-73
2J:104419 Marion JF, Yang C, Caqueret A, Boucher F, Michaud JL, Sim1 and Sim2 are required for the correct targeting of mammillary body axons. Development. 2005 Dec;132(24):5527-37
4J:166534 Medioni C, Bertrand N, Mesbah K, Hudry B, Dupays L, Wolstein O, Washkowitz AJ, Papaioannou VE, Mohun TJ, Harvey RP, Zaffran S, Expression of Slit and Robo genes in the developing mouse heart. Dev Dyn. 2010 Dec;239(12):3303-11
1J:164033 Miller AM, Maurer LR, Zou DJ, Firestein S, Greer CA, Axon fasciculation in the developing olfactory nerve. Neural Dev. 2010;5(1):20
4J:191773 Mirza R, Kivrak BG, Erzurumlu RS, Cooperative slit and netrin signaling in contralateralization of the mouse trigeminothalamic pathway. J Comp Neurol. 2013 Feb 1;521(2):312-25
4J:134543 Nguyen-Ba-Charvet KT, Di Meglio T, Fouquet C, Chedotal A, Robos and slits control the pathfinding and targeting of mouse olfactory sensory axons. J Neurosci. 2008 Apr 16;28(16):4244-9
4J:63171 Niclou SP, Jia L, Raper JA, Slit2 is a repellent for retinal ganglion cell axons. J Neurosci. 2000 Jul 1;20(13):4962-74
1J:181398 Ogata-Iwao M, Inatani M, Iwao K, Takihara Y, Nakaishi-Fukuchi Y, Irie F, Sato S, Furukawa T, Yamaguchi Y, Tanihara H, Heparan sulfate regulates intraretinal axon pathfinding by retinal ganglion cells. Invest Ophthalmol Vis Sci. 2011 Aug;52(9):6671-9
2*J:63188 Piper M, Georgas K, Yamada T, Little M, Expression of the vertebrate slit gene family and their putative receptors, the robo genes, in the developing murine kidney. Mech Dev. 2000 Jun;94(1-2):213-7
6J:135299 Plachez C, Andrews W, Liapi A, Knoell B, Drescher U, Mankoo B, Zhe L, Mambetisaeva E, Annan A, Bannister L, Parnavelas JG, Richards LJ, Sundaresan V, Robos are required for the correct targeting of retinal ganglion cell axons in the visual pathway of the brain. Mol Cell Neurosci. 2008 Apr;37(4):719-30
4J:154741 Prince JE, Cho JH, Dumontier E, Andrews W, Cutforth T, Tessier-Lavigne M, Parnavelas J, Cloutier JF, Robo-2 controls the segregation of a portion of basal vomeronasal sensory neuron axons to the posterior region of the accessory olfactory bulb. J Neurosci. 2009 Nov 11;29(45):14211-22
4J:175561 Ricano-Cornejo I, Altick AL, Garcia-Pena CM, Nural HF, Echevarria D, Miquelajauregui A, Mastick GS, Varela-Echavarria A, Slit-Robo signals regulate pioneer axon pathfinding of the tract of the postoptic commissure in the mammalian forebrain. J Neurosci Res. 2011 Oct;89(10):1531-41
2J:184021 Rugg-Gunn PJ, Cox BJ, Lanner F, Sharma P, Ignatchenko V, McDonald AC, Garner J, Gramolini AO, Rossant J, Kislinger T, Cell-surface proteomics identifies lineage-specific markers of embryo-derived stem cells. Dev Cell. 2012 Apr 17;22(4):887-901
4J:78586 Runko E, Kaprielian Z, Expression of Vema in the developing mouse spinal cord and optic chiasm. J Comp Neurol. 2002 Sep 23;451(3):289-99
2J:89438 Sabatier C, Plump AS, Le Ma, Brose K, Tamada A, Murakami F, Lee EY, Tessier-Lavigne M, The divergent Robo family protein rig-1/Robo3 is a negative regulator of slit responsiveness required for midline crossing by commissural axons. Cell. 2004 Apr 16;117(2):157-69
2J:81202 Shu T, Butz KG, Plachez C, Gronostajski RM, Richards LJ, Abnormal development of forebrain midline glia and commissural projections in Nfia knock-out mice. J Neurosci. 2003 Jan 1;23(1):203-12
1J:68842 Shu T, Richards LJ, Cortical axon guidance by the glial wedge during the development of the corpus callosum. J Neurosci. 2001 Apr 15;21(8):2749-58
1J:96006 Steele-Perkins G, Plachez C, Butz KG, Yang G, Bachurski CJ, Kinsman SL, Litwack ED, Richards LJ, Gronostajski RM, The transcription factor gene Nfib is essential for both lung maturation and brain development. Mol Cell Biol. 2005 Jan;25(2):685-98
14J:87446 Sundaresan V, Mambetisaeva E, Andrews W, Annan A, Knoll B, Tear G, Bannister L, Dynamic expression patterns of Robo (Robo1 and Robo2) in the developing murine central nervous system. J Comp Neurol. 2004 Jan 19;468(4):467-81
3J:167943 Takeuchi H, Inokuchi K, Aoki M, Suto F, Tsuboi A, Matsuda I, Suzuki M, Aiba A, Serizawa S, Yoshihara Y, Fujisawa H, Sakano H, Sequential arrival and graded secretion of Sema3F by olfactory neuron axons specify map topography at the bulb. Cell. 2010 Jun 11;141(6):1056-67
1J:205662 Takeuchi JK, Lou X, Alexander JM, Sugizaki H, Delgado-Olguin P, Holloway AK, Mori AD, Wylie JN, Munson C, Zhu Y, Zhou YQ, Yeh RF, Henkelman RM, Harvey RP, Metzger D, Chambon P, Stainier DY, Pollard KS, Scott IC, Bruneau BG, Chromatin remodelling complex dosage modulates transcription factor function in heart development. Nat Commun. 2011;2:187
2J:154456 Thompson H, Andrews W, Parnavelas JG, Erskine L, Robo2 is required for Slit-mediated intraretinal axon guidance. Dev Biol. 2009 Nov 15;335(2):418-26
1J:104160 Tole S, Gutin G, Bhatnagar L, Remedios R, Hebert JM, Development of midline cell types and commissural axon tracts requires Fgfr1 in the cerebrum. Dev Biol. 2006 Jan 1;289(1):141-51
1J:184936 Unni DK, Piper M, Moldrich RX, Gobius I, Liu S, Fothergill T, Donahoo AL, Baisden JM, Cooper HM, Richards LJ, Multiple Slits regulate the development of midline glial populations and the corpus callosum. Dev Biol. 2012 May 1;365(1):36-49
4J:70834 Vargesson N, Luria V, Messina I, Erskine L, Laufer E, Expression patterns of Slit and Robo family members during vertebrate limb development. Mech Dev. 2001 Aug;106(1-2):175-80
1J:177875 Wang H, Li Q, Liu J, Mendelsohn C, Salant DJ, Lu W, Noninvasive assessment of antenatal hydronephrosis in mice reveals a critical role for Robo2 in maintaining anti-reflux mechanism. PLoS One. 2011;6(9):e24763
2J:199796 Wang SZ, Ibrahim LA, Kim YJ, Gibson DA, Leung HC, Yuan W, Zhang KK, Tao HW, Ma L, Zhang LI, Slit/Robo Signaling Mediates Spatial Positioning of Spiral Ganglion Neurons during Development of Cochlear Innervation. J Neurosci. 2013 Jul 24;33(30):12242-54
4*J:138310 Xu C, Fan CM, Expression of Robo/Slit and Semaphorin/Plexin/Neuropilin family members in the developing hypothalamic paraventricular and supraoptic nuclei. Gene Expr Patterns. 2008 Sep;8(7-8):502-7
1J:83292 Yuan W, Rao Y, Babiuk RP, Greer JJ, Wu JY, Ornitz DM, A genetic model for a central (septum transversum) congenital diaphragmatic hernia in mice lacking Slit3. Proc Natl Acad Sci U S A. 2003 Apr 29;100(9):5217-22

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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory