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Gene Expression Literature Summary
Symbol
Name
ID
Prmt5
protein arginine N-methyltransferase 5
MGI:1351645

15 matching records from 15 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.
Age E0.5 E1 E2 E2.5 E3 E3.5 E4.5 E6.5 E8 E8.5 E9.5 E10.5 E11.5 E12.5 E13 E13.5 E14.5 E15 E16 E16.5 E17 E18 E18.5 E19 E P
Immunohistochemistry (section) 1 1 1 2 2 3 2 1 1 1 3
In situ RNA (section) 1 1 1
Immunohistochemistry (whole mount) 1 1 2 2 1 2 2 2 1
In situ RNA (whole mount) 1 1 1
Western blot 1 1 1 1 1 1 2
RT-PCR 1 1 1 2 1 1 2 1 1 1 2 1 3

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available
Prmt5  protein arginine N-methyltransferase 5   (Synonyms: Jak-binding protein 1, Jbp1, Skb1)
Results  Reference
1J:201152 Bezzi M, Teo SX, Muller J, Mok WC, Sahu SK, Vardy LA, Bonday ZQ, Guccione E, Regulation of constitutive and alternative splicing by PRMT5 reveals a role for Mdm4 pre-mRNA in sensing defects in the spliceosomal machinery. Genes Dev. 2013 Sep 1;27(17):1903-16
3*J:93300 Blackshaw S, Harpavat S, Trimarchi J, Cai L, Huang H, Kuo WP, Weber G, Lee K, Fraioli RE, Cho SH, Yung R, Asch E, Ohno-Machado L, Wong WH, Cepko CL, Genomic analysis of mouse retinal development. PLoS Biol. 2004 Oct;2(9):E247
3*J:222673 Chittka A, Nitarska J, Grazini U, Richardson WD, Transcription factor positive regulatory domain 4 (PRDM4) recruits protein arginine methyltransferase 5 (PRMT5) to mediate histone arginine methylation and control neural stem cell proliferation and differentiation. J Biol Chem. 2012 Dec 14;287(51):42995-3006
1*J:217429 Cho OH, Mallappa C, Hernandez-Hernandez JM, Rivera-Perez JA, Imbalzano AN, Contrasting roles for MyoD in organizing myogenic promoter structures during embryonic skeletal muscle development. Dev Dyn. 2015 Jan;244(1):43-55
1J:112036 Costa Y, Speed RM, Gautier P, Semple CA, Maratou K, Turner JM, Cooke HJ, Mouse MAELSTROM: the link between meiotic silencing of unsynapsed chromatin and microRNA pathway?. Hum Mol Genet. 2006 Aug 1;15(15):2324-34
2J:271634 Hamard PJ, Santiago GE, Liu F, Karl DL, Martinez C, Man N, Mookhtiar AK, Duffort S, Greenblatt S, Verdun RE, Nimer SD, PRMT5 Regulates DNA Repair by Controlling the Alternative Splicing of Histone-Modifying Enzymes. Cell Rep. 2018 Sep 4;24(10):2643-2657
11J:219506 Kim S, Gunesdogan U, Zylicz JJ, Hackett JA, Cougot D, Bao S, Lee C, Dietmann S, Allen GE, Sengupta R, Surani MA, PRMT5 protects genomic integrity during global DNA demethylation in primordial germ cells and preimplantation embryos. Mol Cell. 2014 Nov 20;56(4):564-79
11J:264403 Li Q, Jiao J, Li H, Wan H, Zheng C, Cai J, Bao S, Histone arginine methylation by Prmt5 is required for lung branching morphogenesis through repression of BMP signaling. J Cell Sci. 2018 Jul 25;131(14)
4J:237505 Norrie JL, Li Q, Co S, Huang BL, Ding D, Uy JC, Ji Z, Mackem S, Bedford MT, Galli A, Ji H, Vokes SA, PRMT5 is essential for the maintenance of chondrogenic progenitor cells in the limb bud. Development. 2016 Dec 15;143(24):4608-4619
1J:276643 Oqani RK, Lin T, Lee JE, Kang JW, Shin HY, Il Jin D, Iws1 and Spt6 Regulate Trimethylation of Histone H3 on Lysine 36 through Akt Signaling and are Essential for Mouse Embryonic Genome Activation. Sci Rep. 2019 Mar 7;9(1):3831
5J:264087 Sato A, Kim JD, Mizukami H, Nakashima M, Kako K, Ishida J, Itakura A, Takeda S, Fukamizu A, Gestational changes in PRMT1 expression of murine placentas. Placenta. 2018 May;65:47-54
7J:166736 Tee WW, Pardo M, Theunissen TW, Yu L, Choudhary JS, Hajkova P, Surani MA, Prmt5 is essential for early mouse development and acts in the cytoplasm to maintain ES cell pluripotency. Genes Dev. 2010 Dec 15;24(24):2772-7
1J:151086 Vagin VV, Wohlschlegel J, Qu J, Jonsson Z, Huang X, Chuma S, Girard A, Sachidanandam R, Hannon GJ, Aravin AA, Proteomic analysis of murine Piwi proteins reveals a role for arginine methylation in specifying interaction with Tudor family members. Genes Dev. 2009 Aug 1;23(15):1749-62
6J:277545 Wang Y, Li Q, Liu C, Han F, Chen M, Zhang L, Cui X, Qin Y, Bao S, Gao F, Protein arginine methyltransferase 5 (Prmt5) is required for germ cell survival during mouse embryonic development. Biol Reprod. 2015 Apr;92(4):104
7J:126896 Yildirim AO, Bulau P, Zakrzewicz D, Kitowska KE, Weissmann N, Grimminger F, Morty RE, Eickelberg O, Increased protein arginine methylation in chronic hypoxia: role of protein arginine methyltransferases. Am J Respir Cell Mol Biol. 2006 Oct;35(4):436-43

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/05/2019
MGI 6.14
The Jackson Laboratory