Gene Expression Literature Summary

• Symbol: Map3k4
• Name: mitogen-activated protein kinase kinase kinase 4
• ID: MGI:1346875

12 matching records from 12 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E7	E7.5	E8.5	E9	E9.5	E10.5	E11	E11.5	E12.5	E13	E13.5	E15	E15.5	E16.5	E17	E17.5	E18.5	E	P
Immunohistochemistry (section)		1	1		2														1
In situ RNA (section)		1	1		1	1					1		1	1					2
Immunohistochemistry (whole mount)																1			1
In situ RNA (whole mount)			1	1		1			1		1		1	1					1
Northern blot	1						1					1			1
Western blot						1				1			1			1	1	2
RT-PCR						1		1		1		1	1						1
cDNA clones		1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Map3k4  mitogen-activated protein kinase kinase kinase 4   (Synonyms: D17Rp17, D17Rp17e, MAPKKK4, Mekk4, mKIAA0213, MTK1, RP17, Tas, T-associated sex reversal)
Results	Reference
8	J:148987 Abell AN, Granger DA, Johnson NL, Vincent-Jordan N, Dibble CF, Johnson GL, Trophoblast stem cell maintenance by fibroblast growth factor 4 requires MEKK4 activation of Jun N-terminal kinase. Mol Cell Biol. 2009 May;29(10):2748-61
5	J:101350 Abell AN, Rivera-Perez JA, Cuevas BD, Uhlik MT, Sather S, Johnson NL, Minton SK, Lauder JM, Winter-Vann AM, Nakamura K, Magnuson T, Vaillancourt RR, Heasley LE, Johnson GL, Ablation of MEKK4 kinase activity causes neurulation and skeletal patterning defects in the mouse embryo. Mol Cell Biol. 2005 Oct;25(20):8948-59
3	J:153050 Bogani D, Siggers P, Brixey R, Warr N, Beddow S, Edwards J, Williams D, Wilhelm D, Koopman P, Flavell RA, Chi H, Ostrer H, Wells S, Cheeseman M, Greenfield A, Loss of mitogen-activated protein kinase kinase kinase 4 (MAP3K4) reveals a requirement for MAPK signalling in mouse sex determination. PLoS Biol. 2009 Sep;7(9):e1000196
7*	J:96871 Chi H, Sarkisian MR, Rakic P, Flavell RA, Loss of mitogen-activated protein kinase kinase kinase 4 (MEKK4) results in enhanced apoptosis and defective neural tube development. Proc Natl Acad Sci U S A. 2005 Mar 8;102(10):3846-51
1	J:204550 Fujimoto Y, Tanaka SS, Yamaguchi YL, Kobayashi H, Kuroki S, Tachibana M, Shinomura M, Kanai Y, Morohashi K, Kawakami K, Nishinakamura R, Homeoproteins Six1 and Six4 regulate male sex determination and mouse gonadal development. Dev Cell. 2013 Aug 26;26(4):416-30
1*	J:171409 GUDMAP Consortium, GUDMAP: the GenitoUrinary Development Molecular Anatomy Project. www.gudmap.org. 2004;
9	J:231463 Haque K, Pandey AK, Zheng HW, Riazuddin S, Sha SH, Puligilla C, MEKK4 Signaling Regulates Sensory Cell Development and Function in the Mouse Inner Ear. J Neurosci. 2016 Jan 27;36(4):1347-61
1	J:326026 Prokopuk L, Jarred EG, Blucher RO, McLaughlin EA, Stringer JM, Western PS, An essential role for Polycomb Repressive Complex 2 in the mouse ovary. Reproduction. 2022 Feb 17;163(3):167-182
4*	J:117267 Sarkisian MR, Bartley CM, Chi H, Nakamura F, Hashimoto-Torii K, Torii M, Flavell RA, Rakic P, MEKK4 signaling regulates filamin expression and neuronal migration. Neuron. 2006 Dec 7;52(5):789-801
1	J:42498 Schweifer N, Valk PJ, Delwel R, Cox R, Francis F, Meier-Ewert S , Lehrach H , Barlow DP, Characterization of the C3 YAC contig from proximal mouse chromosome 17 and analysis of allelic expression of genes flanking the imprinted Igf2r gene. Genomics. 1997 Aug 1;43(3):285-97
1	J:308861 Shendy NAM, Broadhurst AL, Shoemaker K, Read R, Abell AN, MAP3K4 kinase activity dependent control of mouse gonadal sex determination. Biol Reprod. 2021 Aug 3;105(2):491-502
1	J:191096 Warr N, Carre GA, Siggers P, Faleato JV, Brixey R, Pope M, Bogani D, Childers M, Wells S, Scudamore CL, Tedesco M, del Barco Barrantes I, Nebreda AR, Trainor PA, Greenfield A, Gadd45gamma and Map3k4 interactions regulate mouse testis determination via p38 MAPK-mediated control of Sry expression. Dev Cell. 2012 Nov 13;23(5):1020-31