Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Kcnma1. (This text reflects annotations as of Tuesday, July 8, 2014.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit, which is the product of this gene, and the modulatory beta subunit. Intracellular calcium regulates the physical association between the alpha and beta subunits. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Kcnma1
  • participates in the following biological processes:
    • potassium ion transport ^{[, ]}
    • protein homooligomerization ^[]
    • regulation of membrane potential ^[]
    • response to hypoxia ^[]
  • performs the following molecular functions:
    • calcium-activated potassium channel activity ^{[, , , , ]}
    • large conductance calcium-activated potassium channel activity ^[]
    • voltage-gated potassium channel activity ^{[, ]}
  • is located in the following cellular components:
    • apical plasma membrane ^[]
    • cytoplasm ^[]
    • endoplasmic reticulum ^[]
    • external side of plasma membrane ^[]
    • integral component of membrane ^[]
    • plasma membrane ^{[, ]}
    • postsynaptic membrane ^[]
    • terminal bouton ^[]
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Kcnma1
  • participates in the following biological processes:
    • adult walking behavior ^{[, ]}
    • auditory receptor cell differentiation ^{[, ]}
    • cell maturation ^[]
    • circadian rhythm ^[]
    • eye blink reflex ^[]
    • locomotor rhythm ^[]
    • micturition ^[]
    • negative regulation of cell volume ^[]
    • neuromuscular process controlling balance ^{[, ]}
    • neuronal action potential ^[]
    • regulation of aldosterone metabolic process ^[]
    • regulation of ion transmembrane transport ^[]
    • regulation of membrane potential ^{[, ]}
    • relaxation of vascular smooth muscle ^[]
    • sensory perception of sound ^{[, ]}
    • smooth muscle contraction involved in micturition ^[]
    • synaptic transmission ^[]
    • vasodilation ^[]
  • performs the following molecular functions:
    • calcium-activated potassium channel activity ^[]
    • large conductance calcium-activated potassium channel activity ^{[, ]}
    • potassium channel activity ^[]
    • voltage-gated potassium channel activity ^[]
• Researchers have inferred, based on genetic interactions, that the gene product of Kcnma1
  • participates in the following biological processes:
    • potassium ion transmembrane transport based on interactions with Kcnmb1, Kcnmb4 ^[]
    • saliva secretion based on interactions with Kcnn4 ^[]
  • performs the following molecular functions:
    • calcium-activated potassium channel activity based on interactions with Kcnmb1, Kcnmb4 ^[]
    • potassium channel activity based on interactions with Kcnn4 ^[]
  • is located in the following cellular components:
    • voltage-gated potassium channel complex based on interactions with Kcnmb1, Kcnmb4 ^[]
• Based on the experimental annotations above, MGI curators have inferred, that the gene product of Kcnma1
  • is located in the following cellular components:
    • integral component of membrane ^[]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Kcnma1:
  • participates in the following biological processes:
    • cellular potassium ion homeostasis
    • micturition
    • negative regulation of cell volume
    • positive regulation of apoptotic process
    • potassium ion transmembrane transport
    • potassium ion transport
    • protein homotetramerization
    • regulation of membrane potential
    • regulation of vasodilation
    • response to calcium ion
    • response to carbon monoxide
    • response to corticosteroid
    • response to estrogen
    • response to hypoxia
    • response to osmotic stress
    • response to pH
    • smooth muscle contraction involved in micturition
  • performs the following molecular functions:
    • actin binding
    • calcium-activated potassium channel activity
    • large conductance calcium-activated potassium channel activity
    • protein complex binding
    • protein homodimerization activity
    • voltage-gated potassium channel activity
  • is located in the following cellular components:
    • apical plasma membrane
    • caveola
    • dendrite
    • external side of plasma membrane
    • extracellular vesicular exosome
    • integral component of membrane
    • neuronal cell body
    • perinuclear region of cytoplasm
    • plasma membrane
    • presynaptic active zone membrane
    • protein complex
    • voltage-gated potassium channel complex

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Summary text based on GO annotations supported by structural data

• Kcnma1 encodes a protein or proteins that contain the following InterPro domains: indicating that the gene product:
  • participates in the following biological processes:
    • ion transport
    • transmembrane transport
  • performs the following molecular functions:
    • ion channel activity
  • is located in the following cellular components:
    • membrane

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Kcnma1 indicates that it:
  • participates in the following biological processes:
    • ion transport
    • transport
  • performs the following molecular functions:
    • metal ion binding
    • voltage-gated ion channel activity
  • is located in the following cellular components:
    • membrane
    • viral envelope
    • virion

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References

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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