Gene Ontology Classifications

Symbol
Name
ID

Kcnma1
potassium large conductance calcium-activated channel, subfamily M, alpha member 1
MGI:99923

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Automated description from the Alliance of Genome Resources

Exhibits identical protein binding activity; large conductance calcium-activated potassium channel activity; and voltage-gated potassium channel activity. Involved in several processes, including adult walking behavior; eye blink reflex; and locomotor rhythm. Localizes to several cellular components, including the apical plasma membrane; external side of plasma membrane; and voltage-gated potassium channel complex. Predicted to colocalize with the mitochondrion. Human ortholog(s) of this gene implicated in Alzheimer's disease and idiopathic generalized epilepsy. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and liver and biliary system. Orthologous to human KCNMA1 (potassium calcium-activated channel subfamily M alpha 1).

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Aspect

Category

Evidence

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP: Inferred from experiment
HMP: Inferred from high throughput mutant phenotype
HGI: Inferred from high throughput genetic interaction
HDA: Inferred from high throughput direct assay
HEP: Inferred from high throughput expression pattern
IDA: Inferred from direct assay
IEP: Inferred from expression pattern
IGI: Inferred from genetic interaction
IMP: Inferred from mutant phenotype
IPI: Inferred from physical interaction

Homology:

IAS: Inferred from ancestral sequence
IBA: Inferred from biological aspect of ancestor
IBD: Inferred from biological aspect of descendant
IKR: Inferred from key residues
IMR: Inferred from missing residues
IRD: Inferred from rapid divergence
ISA: Inferred from sequence alignment
ISM: Inferred from sequence model
ISO: Inferred from sequence orthology
ISS: Inferred from sequence or structural similarity

Automated:

IEA: Inferred from electronic annotation
RCA: Reviewed computational analysis

Other:

IC: Inferred by curator
NAS: Non-traceable author statement
ND: No biological data available
TAS: Traceable author statement

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Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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