Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Usf1. (This text reflects annotations as of Tuesday, May 21, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the basic helix-loop-helix leucine zipper family, and can function as a cellular transcription factor. The encoded protein can activate transcription through pyrimidine-rich initiator (Inr) elements and E-box motifs. This gene has been linked to familial combined hyperlipidemia (FCHL). Alternative splicing of this gene results in multiple transcript variants. A related pseudogene has been defined on chromosome 21. [provided by RefSeq, Feb 2013]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Usf1
  • participates in the following biological processes:
    • positive regulation of transcription, DNA-dependent ^[3]
  • performs the following molecular functions:
    • DNA binding ^[3]
    • sequence-specific DNA binding transcription factor activity ^[3]
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Usf1
  • participates in the following biological processes:
    • lipid homeostasis ^[1]
    • positive regulation of transcription from RNA polymerase II promoter by glucose ^[1]
    • response to UV ^[2]
• Based on the experimental annotations above, MGI curators have inferred, that the gene product of Usf1
  • is located in the following cellular components:
    • transcription factor complex ^[3]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Usf1:
  • participates in the following biological processes:
    • cellular response to insulin stimulus
    • glucose metabolic process
    • late viral mRNA transcription
    • positive regulation of transcription from RNA polymerase II promoter
    • positive regulation of transcription from RNA polymerase II promoter by glucose
    • regulation of transcription, DNA-dependent
    • response to hypoxia
    • transcription from RNA polymerase II promoter
  • performs the following molecular functions:
    • bHLH transcription factor binding
    • DNA binding
    • double-stranded DNA binding
    • enzyme binding
    • histone deacetylase binding
    • protein heterodimerization activity
    • protein homodimerization activity
    • protein kinase binding
    • RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
    • sequence-specific DNA binding
    • sequence-specific DNA binding transcription factor activity
  • is located in the following cellular components:
    • nucleus
    • transcription factor complex

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Summary text based on GO annotations supported by structural data

• Usf1 encodes a protein or proteins that contain the following InterPro domains: Myc-type, basic helix-loop-helix (bHLH) domain, indicating that the gene product:
  • performs the following molecular functions:
    • protein dimerization activity

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Usf1 indicates that it:
  • participates in the following biological processes:
    • transcription, DNA-dependent

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References

1. Casado M et al. (1999) Essential role in vivo of upstream stimulatory factors for a normal dietary response of the fatty acid synthase gene in the liver. J Biol Chem, 274:2009-13. (PubMed:9890958)
2. Corre S et al. (2004) UV-induced expression of key component of the tanning process, the POMC and MC1R genes, is dependent on the p-38-activated upstream stimulating factor-1 (USF-1). J Biol Chem, 279:51226-33. (PubMed:15358786)
3. Firlej V et al. (2005) Pea3 transcription factor cooperates with USF-1 in regulation of the murine bax transcription without binding to an Ets-binding site. J Biol Chem, 280:887-98. (PubMed:15466854)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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