Automated description from the Alliance of Genome Resources
Exhibits inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity and phosphatidylinositol binding activity. Involved in calcium ion transport; cellular response to cAMP; and cellular response to ethanol. Localizes to the cell cortex and sarcoplasmic reticulum. Used to study isolated anhidrosis with normal sweat glands. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis and isolated anhidrosis with normal sweat glands. Is expressed in medulla oblongata and medulla oblongata basal plate mantle layer. Orthologous to human ITPR2 (inositol 1,4,5-trisphosphate receptor type 2).