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Gene Ontology Classifications
Symbol
Name
ID
Xbp1
X-box binding protein 1
MGI:98970

Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Xbp1. (This text reflects annotations as of Tuesday, May 26, 2015.)
Summary from NCBI RefSeq


[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a transcription factor that regulates MHC class II genes by binding to a promoter element referred to as an X box. This gene product is a bZIP protein, which was also identified as a cellular transcription factor that binds to an enhancer in the promoter of the T cell leukemia virus type 1 promoter. It may increase expression of viral proteins by acting as the DNA binding partner of a viral transactivator. It has been found that upon accumulation of unfolded proteins in the endoplasmic reticulum (ER), the mRNA of this gene is processed to an active form by an unconventional splicing mechanism that is mediated by the endonuclease inositol-requiring enzyme 1 (IRE1). The resulting loss of 26 nt from the spliced mRNA causes a frame-shift and an isoform XBP1(S), which is the functionally active transcription factor. The isoform encoded by the unspliced mRNA, XBP1(U), is constitutively expressed, and thought to function as a negative feedback regulator of XBP1(S), which shuts off transcription of target genes during the recovery phase of ER stress. A pseudogene of XBP1 has been identified and localized to chromosome 5. [provided by RefSeq, Jul 2008]
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by experimental evidence in other organisms
Summary text based on GO annotations supported by structural data
Summary text for additional MGI annotations
References
  1. Acosta-Alvear D et al. (2007) XBP1 controls diverse cell type- and condition-specific transcriptional regulatory networks. Mol Cell, 27:53-66. (PubMed:17612490)
  2. Clauss IM et al. (1996) The basic domain/leucine zipper protein hXBP-1 preferentially binds to and transactivates CRE-like sequences containing an ACGT core. Nucleic Acids Res, 24:1855-64. (PubMed:8657566)
  3. Gregor MF et al. (2013) The role of adipocyte XBP1 in metabolic regulation during lactation. Cell Rep, 3:1430-9. (PubMed:23623498)
  4. Iwakoshi NN et al. (2003) Plasma cell differentiation and the unfolded protein response intersect at the transcription factor XBP-1. Nat Immunol, 4:321-9. (PubMed:12612580)
  5. Lee AH et al. (2003) XBP-1 regulates a subset of endoplasmic reticulum resident chaperone genes in the unfolded protein response. Mol Cell Biol, 23:7448-59. (PubMed:14559994)
  6. Lee AH et al. (2008) Regulation of hepatic lipogenesis by the transcription factor XBP1. Science, 320:1492-6. (PubMed:18556558)
  7. Lee AH et al. (2005) XBP-1 is required for biogenesis of cellular secretory machinery of exocrine glands. EMBO J, 24:4368-80. (PubMed:16362047)
  8. Lisbona F et al. (2009) BAX inhibitor-1 is a negative regulator of the ER stress sensor IRE1alpha. Mol Cell, 33:679-91. (PubMed:19328063)
  9. Park SW et al. (2010) The regulatory subunits of PI3K, p85alpha and p85beta, interact with XBP-1 and increase its nuclear translocation. Nat Med, 16:429-37. (PubMed:20348926)
  10. Reimold AM et al. (2000) An essential role in liver development for transcription factor XBP-1. Genes Dev, 14:152-7. (PubMed:10652269)
  11. Tirosh B et al. (2006) Rapid turnover of unspliced Xbp-1 as a factor that modulates the unfolded protein response. J Biol Chem, 281:5852-60. (PubMed:16332684)
  12. Valdes P et al. (2014) Control of dopaminergic neuron survival by the unfolded protein response transcription factor XBP1. Proc Natl Acad Sci U S A, 111:6804-9. (PubMed:24753614)
  13. Wang FM et al. (2011) Regulation of unfolded protein response modulator XBP1s by acetylation and deacetylation. Biochem J, 433:245-52. (PubMed:20955178)
  14. Zeng L et al. (2013) Vascular endothelial cell growth-activated XBP1 splicing in endothelial cells is crucial for angiogenesis. Circulation, 127:1712-22. (PubMed:23529610)
  15. Zhang Y et al. (2012) Transcriptional regulation of the Ufm1 conjugation system in response to disturbance of the endoplasmic reticulum homeostasis and inhibition of vesicle trafficking. PLoS One, 7:e48587. (PubMed:23152784)
  16. Zhou Y et al. (2011) Regulation of glucose homeostasis through a XBP-1-FoxO1 interaction. Nat Med, 17:356-65. (PubMed:21317886)



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Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IAS Inferred from ancestral sequence
  IBA Inferred from biological aspect of ancestor
  IBD Inferred from biological aspect of descendant
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IKR Inferred from key residues
  IMP Inferred from mutant phenotype
  IMR Inferred from missing residues
  IPI Inferred from physical interaction
  IRD Inferred from rapid divergence
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement

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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory