Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Tyr. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] The enzyme encoded by this gene catalyzes the first 2 steps, and at least 1 subsequent step, in the conversion of tyrosine to melanin. The enzyme has both tyrosine hydroxylase and dopa oxidase catalytic activities, and requires copper for function. Mutations in this gene result in oculocutaneous albinism, and nonpathologic polymorphisms result in skin pigmentation variation. The human genome contains a pseudogene similar to the 3' half of this gene. [provided by RefSeq, Oct 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Tyr
  • performs the following molecular functions:
    • protein heterodimerization activity ^[4]
    • protein homodimerization activity ^[4]
  • is located in the following cellular components:
    • melanosome ^[4]
• The gene product of Tyr has been shown to bind to the gene products of Tyrp1. ^[4]
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Tyr
  • participates in the following biological processes:
    • cell proliferation ^[3]
    • melanin biosynthetic process ^{[3, 6]}
    • pigmentation ^{[1, 3, 5]}
    • thymus development ^[2]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Tyr:
  • participates in the following biological processes:
    • oxidation-reduction process
    • pigmentation
  • performs the following molecular functions:
    • copper ion binding
    • monophenol monooxygenase activity
  • is located in the following cellular components:
    • cytoplasm
    • perinuclear region of cytoplasm

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Summary text based on GO annotations supported by structural data

• Tyr encodes a protein or proteins that contain the following InterPro domains: Tyrosinase, Uncharacterised domain, di-copper centre, indicating that the gene product:
  • participates in the following biological processes:
    • metabolic process
  • performs the following molecular functions:
    • oxidoreductase activity

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Tyr indicates that it:
  • performs the following molecular functions:
    • metal ion binding
    • monooxygenase activity
    • oxidoreductase activity
  • is located in the following cellular components:
    • membrane

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References

1. Coleman DL. (1962) Effect of genic substitution on the incorporation of tyrosine into the melanin of mouse skin. Arch Biochem Biophys, 96:562-8. (PubMed:13880466)
2. DeRossi C et al. (2000) Mouse fzd4 maps within a region of chromosome 7 important for thymus and cardiac development. Genesis, 27:64-75. (PubMed:10890980)
3. Hirobe T et al. (1998) Effects of genic substitution at the agouti, brown, albino, dilute, and pink-eyed dilution loci on the proliferation and differentiation of mouse epidermal melanocytes in serum-free culture. Eur J Cell Biol, 75:184-91. (PubMed:9548375)
4. Jimenez-Cervantes C et al. (1998) Molecular interactions within the melanogenic complex: formation of heterodimers of tyrosinase and TRP1 from B16 mouse melanoma. Biochem Biophys Res Commun, 253:761-7. (PubMed:9918801)
5. Markert CL et al. (1956) The Effects of Genotype and Cell Environment on Melanoblast Differentiation in the House Mouse. Genetics, 41:429-50. (PubMed:17247639)
6. Ozeki H et al. (1995) Chemical characterization of hair melanins in various coat-color mutants of mice. J Invest Dermatol, 105:361-6. (PubMed:7665913)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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