Automated description from the Alliance of Genome Resources (Release 4.1.0)
Predicted to enable several functions, including folic acid binding activity; nucleic acid binding activity; and protein homodimerization activity. Predicted to be involved in dTMP biosynthetic process; negative regulation of translation; and tetrahydrofolate interconversion. Predicted to act upstream of or within methylation and nucleotide biosynthetic process. Predicted to be located in mitochondrial inner membrane; mitochondrial matrix; and nucleolus. Predicted to be active in cytosol and mitochondrion. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in gastrointestinal system cancer (multiple); hematologic cancer (multiple); and rheumatoid arthritis. Orthologous to human TYMS (thymidylate synthetase).