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Gene Ontology Classifications
twist basic helix-loop-helix transcription factor 1

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GO curators for mouse genes have assigned the following annotations to the gene product of Twist1. (This text reflects annotations as of Tuesday, May 26, 2015.)
Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] Basic helix-loop-helix (bHLH) transcription factors have been implicated in cell lineage determination and differentiation. The protein encoded by this gene is a bHLH transcription factor and shares similarity with another bHLH transcription factor, Dermo1. The strongest expression of this mRNA is in placental tissue; in adults, mesodermally derived tissues express this mRNA preferentially. Mutations in this gene have been found in patients with Saethre-Chotzen syndrome. [provided by RefSeq, Jul 2008]
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by experimental evidence in other organisms
Summary text based on GO annotations supported by structural data
Summary text for additional MGI annotations
  1. Bialek P et al. (2004) A twist code determines the onset of osteoblast differentiation. Dev Cell, 6:423-35. (PubMed:15030764)
  2. Browning VL et al. (2001) Mutations of the Mouse Twist and sy (Fibrillin 2) Genes Induced by Chemical Mutagenesis of ES Cells. Genomics, 73:291-8. (PubMed:11350121)
  3. Carver EA et al. (2002) Craniosynostosis in Twist heterozygous mice: A model for Saethre-Chotzen syndrome. Anat Rec, 268:90-2. (PubMed:12221714)
  4. Chakraborty S et al. (2010) Twist1 promotes heart valve cell proliferation and extracellular matrix gene expression during development in vivo and is expressed in human diseased aortic valves. Dev Biol, 347:167-79. (PubMed:20804746)
  5. Chen ZF et al. (1995) twist is required in head mesenchyme for cranial neural tube morphogenesis. Genes Dev, 9:686-99. (PubMed:7729687)
  6. Connerney J et al. (2006) Twist1 dimer selection regulates cranial suture patterning and fusion. Dev Dyn, 235:1334-46. (PubMed:16502419)
  7. Curtis AM et al. (2004) Histone acetyltransferase-dependent chromatin remodeling and the vascular clock. J Biol Chem, 279:7091-7. (PubMed:14645221)
  8. el Azzouzi H et al. (2013) The hypoxia-inducible microRNA cluster miR-199a approximately 214 targets myocardial PPARdelta and impairs mitochondrial fatty acid oxidation. Cell Metab, 18:341-54. (PubMed:24011070)
  9. el Ghouzzi V et al. (1997) Mutations of the TWIST gene in the Saethre-Chotzen syndrome [see comments] Nat Genet, 15:42-6. (PubMed:8988167)
  10. Hebrok M et al. (1994) M-twist is an inhibitor of muscle differentiation. Dev Biol, 165:537-44. (PubMed:7958419)
  11. Horikawa T et al. (2007) Twist and epithelial-mesenchymal transition are induced by the EBV oncoprotein latent membrane protein 1 and are associated with metastatic nasopharyngeal carcinoma. Cancer Res, 67:1970-8. (PubMed:17332324)
  12. Laursen KB et al. (2007) Mechanism of transcriptional activation by the proto-oncogene Twist1. J Biol Chem, 282:34623-33. (PubMed:17893140)
  13. Munroe RJ et al. (2000) Mouse mutants from chemically mutagenized embryonic stem cells. Nat Genet, 24:318-21. (PubMed:10700192)
  14. O'Rourke MP et al. (2002) Twist plays an essential role in FGF and SHH signal transduction during mouse limb development. Dev Biol, 248:143-56. (PubMed:12142027)
  15. Ota MS et al. (2004) Twist is required for patterning the cranial nerves and maintaining the viability of mesodermal cells. Dev Dyn, 230:216-28. (PubMed:15162501)
  16. Pan D et al. (2009) Twist-1 is a PPARdelta-inducible, negative-feedback regulator of PGC-1alpha in brown fat metabolism. Cell, 137:73-86. (PubMed:19345188)
  17. Phinney DG et al. (2006) Biological activities encoded by the murine mesenchymal stem cell transcriptome provide a basis for their developmental potential and broad therapeutic efficacy. Stem Cells, 24:186-98. (PubMed:16100003)
  18. Piccinin S et al. (2012) A "twist box" code of p53 inactivation: twist box: p53 interaction promotes p53 degradation. Cancer Cell, 22:404-15. (PubMed:22975381)
  19. Rohwedel J et al. (1995) M-twist expression inhibits mouse embryonic stem cell-derived myogenic differentiation in vitro. Exp Cell Res, 220:92-100. (PubMed:7664846)
  20. Sharif MN et al. (2006) Twist mediates suppression of inflammation by type I IFNs and Axl. J Exp Med, 203:1891-901. (PubMed:16831897)
  21. Vincentz JW et al. (2008) An absence of Twist1 results in aberrant cardiac neural crest morphogenesis. Dev Biol, 320:131-9. (PubMed:18539270)
  22. Yang MH et al. (2008) Direct regulation of TWIST by HIF-1alpha promotes metastasis. Nat Cell Biol, 10:295-305. (PubMed:18297062)
  23. Yasui K et al. (1998) Expression of a twist-related gene, Bbtwist, during the development of a lancelet species and its relation to cephalochordate anterior structures. Dev Biol, 195:49-59. (PubMed:9520323)
  24. Zuniga A et al. (2002) Mouse Twist is required for fibroblast growth factor-mediated epithelial-mesenchymal signalling and cell survival during limb morphogenesis. Mech Dev, 114:51. (PubMed:12175489)

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Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IAS Inferred from ancestral sequence
  IBA Inferred from biological aspect of ancestor
  IBD Inferred from biological aspect of descendant
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IKR Inferred from key residues
  IMP Inferred from mutant phenotype
  IMR Inferred from missing residues
  IPI Inferred from physical interaction
  IRD Inferred from rapid divergence
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


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