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Gene Ontology Classifications
T cell acute lymphocytic leukemia 1

Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Tal1. (This text reflects annotations as of Tuesday, May 26, 2015.) MGI curation of this mouse gene is considered complete, including annotations derived from the biomedical literature as of September 27, 2011. If you know of any additional information regarding this mouse gene please let us know. Please supply mouse gene symbol and a PubMed ID.
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by experimental evidence in other organisms
Summary text based on GO annotations supported by structural data
Summary text for additional MGI annotations
  1. Bloor AJ et al. (2005) RFP represses transcriptional activation by bHLH transcription factors. Oncogene, 24:6729-36. (PubMed:16007160)
  2. Bradley CK et al. (2006) The essential haematopoietic transcription factor Scl is also critical for neuronal development. Eur J Neurosci, 23:1677-89. (PubMed:16623824)
  3. Cai Y et al. (2009) Eto2/MTG16 and MTGR1 are heteromeric corepressors of the TAL1/SCL transcription factor in murine erythroid progenitors. Biochem Biophys Res Commun, 390:295-301. (PubMed:19799863)
  4. Chervinsky DS et al. (1999) Disordered T-cell development and T-cell malignancies in SCL LMO1 double-transgenic mice: parallels with E2A-deficient mice. Mol Cell Biol, 19:5025-35. (PubMed:10373552)
  5. Curtis DJ et al. (2004) SCL is required for normal function of short-term repopulating hematopoietic stem cells. Blood, 103:3342-8. (PubMed:14726374)
  6. D'Souza SL et al. (2005) SCL/Tal-1 is essential for hematopoietic commitment of the hemangioblast but not for its development. Blood, 105:3862-70. (PubMed:15677567)
  7. Dey S et al. (2010) The TAL1/SCL transcription factor regulates cell cycle progression and proliferation in differentiating murine bone marrow monocyte precursors. Mol Cell Biol, 30:2181-92. (PubMed:20194619)
  8. Elefanty AG et al. (1997) Hematopoietic-specific genes are not induced during in vitro differentiation of scl-null embryonic stem cells. Blood, 90:1435-47. (PubMed:9269761)
  9. Ema M et al. (2003) Combinatorial effects of Flk1 and Tal1 on vascular and hematopoietic development in the mouse. Genes Dev, 17:380-93. (PubMed:12569129)
  10. Endoh M et al. (2002) SCL/tal-1-dependent process determines a competence to select the definitive hematopoietic lineage prior to endothelial differentiation. EMBO J, 21:6700-8. (PubMed:12485991)
  11. Goardon N et al. (2006) ETO2 coordinates cellular proliferation and differentiation during erythropoiesis. EMBO J, 25:357-66. (PubMed:16407974)
  12. Hall MA et al. (2003) The critical regulator of embryonic hematopoiesis, SCL, is vital in the adult for megakaryopoiesis, erythropoiesis, and lineage choice in CFU-S12. Proc Natl Acad Sci U S A, 100:992-7. (PubMed:12552125)
  13. Hofmann TJ et al. (1996) The TAL1/Scl basic helix-loop-helix protein blocks myogenic differentiation and E-box dependent transactivation. Oncogene, 13:617-24. (PubMed:8760303)
  14. Hu X et al. (2009) LSD1-mediated epigenetic modification is required for TAL1 function and hematopoiesis. Proc Natl Acad Sci U S A, 106:10141-6. (PubMed:19497860)
  15. Joshi K et al. (2009) LMO4 controls the balance between excitatory and inhibitory spinal V2 interneurons. Neuron, 61:839-51. (PubMed:19323994)
  16. Kassouf MT et al. (2008) Differential use of SCL/TAL-1 DNA-binding domain in developmental hematopoiesis. Blood, 112:1056-67. (PubMed:18550854)
  17. Kunisato A et al. (2004) Stem cell leukemia protein directs hematopoietic stem cell fate. Blood, 103:3336-41. (PubMed:14726394)
  18. Lacombe J et al. (2010) Scl regulates the quiescence and the long-term competence of hematopoietic stem cells. Blood, 115:792-803. (PubMed:19850742)
  19. Lancrin C et al. (2009) The haemangioblast generates haematopoietic cells through a haemogenic endothelium stage. Nature, 457:892-5. (PubMed:19182774)
  20. Landry JR et al. (2008) Runx genes are direct targets of Scl/Tal1 in the yolk sac and fetal liver. Blood, 111:3005-14. (PubMed:18184866)
  21. Maruyama K et al. (2013) Strawberry notch homologue 2 regulates osteoclast fusion by enhancing the expression of DC-STAMP. J Exp Med, 210:1947-60. (PubMed:23980096)
  22. McCormack MP et al. (2006) A critical role for the transcription factor Scl in platelet production during stress thrombopoiesis. Blood, 108:2248-56. (PubMed:16763211)
  23. Muroyama Y et al. (2005) Specification of astrocytes by bHLH protein SCL in a restricted region of the neural tube. Nature, 438:360-3. (PubMed:16292311)
  24. O'Neil J et al. (2001) The DNA binding activity of TAL-1 is not required to induce leukemia/lymphoma in mice. Oncogene, 20:3897-905. (PubMed:11439353)
  25. Ono Y et al. (1998) TAL1 and LIM-only proteins synergistically induce retinaldehyde dehydrogenase 2 expression in T-cell acute lymphoblastic leukemia by acting as cofactors for GATA3. Mol Cell Biol, 18:6939-50. (PubMed:9819382)
  26. Pimanda JE et al. (2007) Gata2, Fli1, and Scl form a recursively wired gene-regulatory circuit during early hematopoietic development. Proc Natl Acad Sci U S A, 104:17692-7. (PubMed:17962413)
  27. Prasad KS et al. (1997) Target-dependent effect of phosphorylation on the DNA binding activity of the TAL1/SCL oncoprotein. J Biol Chem, 272:11457-62. (PubMed:9111058)
  28. Robb L et al. (1995) Absence of yolk sac hematopoiesis from mice with a targeted disruption of the scl gene. Proc Natl Acad Sci U S A, 92:7075-9. (PubMed:7624372)
  29. Robb L et al. (1996) The scl gene product is required for the generation of all hematopoietic lineages in the adult mouse. EMBO J, 15:4123-9. (PubMed:8861941)
  30. Salmon JM et al. (2007) Aberrant mast-cell differentiation in mice lacking the stem-cell leukemia gene. Blood, 110:3573-81. (PubMed:17644741)
  31. Sanchez MJ et al. (2001) Selective rescue of early haematopoietic progenitors in Scl(-/-) mice by expressing Scl under the control of a stem cell enhancer. Development, 128:4815-27. (PubMed:11731461)
  32. Schlaeger TM et al. (2004) Decoding hematopoietic specificity in the helix-loop-helix domain of the transcription factor SCL/Tal-1. Mol Cell Biol, 24:7491-502. (PubMed:15314159)
  33. Schlaeger TM et al. (2005) Tie2Cre-mediated gene ablation defines the stem-cell leukemia gene (SCL/tal1)-dependent window during hematopoietic stem-cell development. Blood, 105:3871-4. (PubMed:15677556)
  34. Shivdasani RA et al. (1995) Absence of blood formation in mice lacking the T-cell leukaemia oncoprotein tal-1/SCL. Nature, 373:432-4. (PubMed:7830794)
  35. Smith ED et al. (2004) More than blood, a novel gene required for mammalian postimplantation development. Mol Cell Biol, 24:1168-73. (PubMed:14729962)
  36. Souroullas GP et al. (2009) Adult hematopoietic stem and progenitor cells require either Lyl1 or Scl for survival. Cell Stem Cell, 4:180-6. (PubMed:19200805)
  37. Tripic T et al. (2009) SCL and associated proteins distinguish active from repressive GATA transcription factor complexes. Blood, 113:2191-201. (PubMed:19011221)
  38. Visvader JE et al. (1997) The LIM-domain binding protein Ldb1 and its partner LMO2 act as negative regulators of erythroid differentiation. Proc Natl Acad Sci U S A, 94:13707-12. (PubMed:9391090)
  39. Visvader JE et al. (1998) Unsuspected role for the T-cell leukemia protein SCL/tal-1 in vascular development. Genes Dev, 12:473-9. (PubMed:9472016)

Go Annotations in Tabular Form (Text View) (GO Graph)

Filter Markers by: Category  Evidence Code 


Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IAS Inferred from ancestral sequence
  IBA Inferred from biological aspect of ancestor
  IBD Inferred from biological aspect of descendant
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IKR Inferred from key residues
  IMP Inferred from mutant phenotype
  IMR Inferred from missing residues
  IPI Inferred from physical interaction
  IRD Inferred from rapid divergence
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


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