Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Sstr1. (This text reflects annotations as of Tuesday, May 21, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] Somatostatins are peptide hormones that regulate diverse cellular functions such as neurotransmission, cell proliferation, and endocrine signaling as well as inhibiting the release of many hormones and other secretory proteins. Somatostatin has two active forms of 14 and 28 amino acids. The biological effects of somatostatins are mediated by a family of G-protein coupled somatostatin receptors that are expressed in a tissue-specific manner. The protein encoded by this gene is a member of the superfamily of somatostatin receptors having seven transmembrane segments. Somatostatin receptors form homodimers and heterodimers with other members of the superfamily as well as with other G-protein coupled receptors and receptor tyrosine kinases. This somatostatin receptor has greater affinity for somatostatin-14 than -28. [provided by RefSeq, Jul 2012]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Sstr1
  • participates in the following biological processes:
    • glutamate receptor signaling pathway ^[2]
    • neuropeptide signaling pathway ^[2]
    • synaptic transmission ^[1]
  • performs the following molecular functions:
    • somatostatin receptor activity ^[1]
  • is located in the following cellular components:
    • membrane ^[1]
    • plasma membrane ^[2]
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Sstr1
  • participates in the following biological processes:
    • G-protein coupled receptor signaling pathway ^[1]
    • neuropeptide signaling pathway ^[1]
    • synaptic transmission ^[1]
  • performs the following molecular functions:
    • somatostatin receptor activity ^[1]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Sstr1:
  • participates in the following biological processes:
    • neuropeptide signaling pathway
    • somatostatin signaling pathway
    • synaptic transmission
  • performs the following molecular functions:
    • somatostatin receptor activity
  • is located in the following cellular components:
    • cytoplasm
    • plasma membrane

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Summary text based on GO annotations supported by structural data

• Sstr1 encodes a protein or proteins that contain the following InterPro domains: G protein-coupled receptor, rhodopsin-like, GPCR, rhodopsin-like, 7TM, Somatostatin receptor 1, Somatostatin receptor family, indicating that the gene product:
  • participates in the following biological processes:
    • negative regulation of cell proliferation
  • performs the following molecular functions:
    • G-protein coupled receptor activity
  • is located in the following cellular components:
    • integral to membrane

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Sstr1 indicates that it:
  • participates in the following biological processes:
    • signal transduction
  • performs the following molecular functions:
    • G-protein coupled receptor activity
    • signal transducer activity
  • is located in the following cellular components:
    • integral to membrane

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References

1. Fitzpatrick VD et al. (1994) 6agonist selectivity determinants in somatostatin receptor subtypes I and II. J Biol Chem, 269:24621-6. (PubMed:7929134)
2. Viollet C et al. (1997) Distinct patterns of expression and physiological effects of sst1 and sst2 receptor subtypes in mouse hypothalamic neurons and astrocytes in culture. J Neurochem, 68:2273-80. (PubMed:9166719)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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