Automated description from the Alliance of Genome Resources (Release 7.0.0)
Enables D-sorbitol dehydrogenase (acceptor) activity; D-xylulose reductase activity; and L-iditol 2-dehydrogenase activity. Involved in flagellated sperm motility; fructose biosynthetic process; and glucuronate catabolic process to xylulose 5-phosphate. Acts upstream of or within sorbitol metabolic process. Located in mitochondrion and motile cilium. Is active in cytosol. Is expressed in several structures, including alimentary system; limb; liver; metanephros; and nervous system. Used to study cataract. Human ortholog(s) of this gene implicated in sorbitol dehydrogenase deficiency with peripheral neuropathy. Orthologous to human SORD (sorbitol dehydrogenase).