Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Ccl3. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This locus represents a small inducible cytokine. The encoded protein, also known as macrophage inflammatory protein 1 alpha, plays a role in inflammatory responses through binding to the receptors CCR1, CCR4 and CCR5. Polymorphisms at this locus may be associated with both resistance and susceptibility to infection by human immunodeficiency virus type 1.[provided by RefSeq, Sep 2010]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Ccl3
  • participates in the following biological processes:
    • astrocyte cell migration ^[5]
    • regulation of cell shape ^[5]
  • performs the following molecular functions:
    • chemokine activity ^[4]
  • is located in the following cellular components:
    • extracellular space ^[1]
• The gene product of Ccl3 has been shown to bind to the gene products of Ccbp2, Ccr1, Ccr3. ^{[3, 4]}
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Ccl3
  • participates in the following biological processes:
    • positive regulation of transcription from RNA polymerase II promoter ^[5]
• Researchers have inferred, based on genetic interactions, that the gene product of Ccl3
  • participates in the following biological processes:
    • macrophage chemotaxis based on interactions with Zfp36 ^[2]
    • positive regulation of inflammatory response based on interactions with Zfp36 ^[2]
    • positive regulation of interleukin-1 beta secretion based on interactions with Zfp36 ^[2]
    • positive regulation of neuron apoptotic process based on interactions with Hexb ^[5]
    • positive regulation of tumor necrosis factor production based on interactions with Zfp36 ^[2]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Ccl3:
  • participates in the following biological processes:
    • behavior
    • calcium ion transport
    • calcium-mediated signaling
    • cell activation
    • cell-cell signaling
    • cellular calcium ion homeostasis
    • cellular response to organic cyclic compound
    • chemotaxis
    • cytoskeleton organization
    • elevation of cytosolic calcium ion concentration
    • eosinophil chemotaxis
    • eosinophil degranulation
    • exocytosis
    • granulocyte chemotaxis
    • inflammatory response
    • leukocyte chemotaxis
    • lipopolysaccharide-mediated signaling pathway
    • lymphocyte chemotaxis
    • MAPK cascade
    • monocyte chemotaxis
    • negative regulation by host of viral transcription
    • negative regulation of bone mineralization
    • negative regulation of gene expression
    • negative regulation of osteoclast differentiation
    • neutrophil chemotaxis
    • phosphorylation
    • positive chemotaxis
    • positive regulation of calcium ion transport
    • positive regulation of calcium-mediated signaling
    • positive regulation of catalytic activity
    • positive regulation of cell migration
    • positive regulation of ERK1 and ERK2 cascade
    • positive regulation of gene expression
    • positive regulation of natural killer cell chemotaxis
    • positive regulation of osteoclast differentiation
    • protein kinase B signaling cascade
    • protein phosphorylation
    • regulation of cell shape
    • regulation of sensory perception of pain
    • release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
    • response to cholesterol
    • response to toxin
    • T cell chemotaxis
  • performs the following molecular functions:
    • calcium-dependent protein kinase C activity
    • CCR1 chemokine receptor binding
    • CCR5 chemokine receptor binding
    • chemoattractant activity
    • chemokine activity
    • kinase activity
    • phospholipase activator activity
    • protein kinase activity
  • is located in the following cellular components:
    • cytoplasm
    • cytosol
    • extracellular region
    • extracellular space
    • intracellular

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Summary text based on GO annotations supported by structural data

• Ccl3 encodes a protein or proteins that contain the following InterPro domains: CC chemokine, conserved site, Chemokine interleukin-8-like domain, indicating that the gene product:
  • participates in the following biological processes:
    • immune response

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Ccl3 indicates that it:
  • performs the following molecular functions:
    • cytokine activity

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References

1. Deshmukh HS et al. (2009) Critical role of NOD2 in regulating the immune response to Staphylococcus aureus. Infect Immun, 77:1376-82. (PubMed:19139201)
2. Kang JG et al. (2011) Zinc finger protein tristetraprolin interacts with CCL3 mRNA and regulates tissue inflammation. J Immunol, 187:2696-701. (PubMed:21784977)
3. Nibbs RJB et al. (1997) Cloning and characterization of a novel murine beta chemokine receptor, D6. Comparison to three other related macrophage inflammatory protein-1alpha receptors, CCR-1, CCR-3, and CCR-5. J Biol Chem, 272:12495-504. (PubMed:9139699)
4. Post TW et al. (1995) Molecular characterization of two murine eosinophil beta chemokine receptors. J Immunol, 155:5299-305. (PubMed:7594543)
5. Wu YP et al. (2004) Deletion of macrophage-inflammatory protein 1 alpha retards neurodegeneration in Sandhoff disease mice. Proc Natl Acad Sci U S A, 101:8425-30. (PubMed:15155903)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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