Automated description from the Alliance of Genome Resources (Release 7.0.0)
Enables CCR2 chemokine receptor binding activity and cytokine activity. Involved in several processes, including cellular response to cytokine stimulus; positive regulation of leukocyte chemotaxis; and regulation of macromolecule biosynthetic process. Acts upstream of or within response to bacterium and response to wounding. Located in extracellular space. Is expressed in several structures, including heart; intestine; mandible; nervous system; and retina. Used to study age related macular degeneration. Human ortholog(s) of this gene implicated in several diseases, including Henoch-Schoenlein purpura; aggressive periodontitis; autoimmune disease (multiple); gastrointestinal system cancer (multiple); and lung disease (multiple). Orthologous to several human genes including CCL2 (C-C motif chemokine ligand 2).