GO Annotations Graph

• Symbol: Ccl2
• Name: C-C motif chemokine ligand 2
• ID: MGI:98259

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0048020	CCR chemokine receptor binding	IBA	J:265628
Molecular Function	GO:0031727	CCR2 chemokine receptor binding	IPI	J:33019
Molecular Function	GO:0008009	chemokine activity	ISO	J:155856
Molecular Function	GO:0008009	chemokine activity	ISO	J:164563
Molecular Function	GO:0008009	chemokine activity	IBA	J:265628
Molecular Function	GO:0005125	cytokine activity	IDA	J:193599
Molecular Function	GO:0001664	G protein-coupled receptor binding	IDA	J:32263
Molecular Function	GO:0001664	G protein-coupled receptor binding	IDA	J:44345
Molecular Function	GO:0008201	heparin binding	ISO	J:155856
Molecular Function	GO:0005515	protein binding	IPI	J:247428
Molecular Function	GO:0005515	protein binding	IPI	J:32263
Cellular Component	GO:0043679	axon terminus	ISO	J:155856
Cellular Component	GO:0044299	C-fiber	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0030425	dendrite	ISO	J:155856
Cellular Component	GO:0030139	endocytic vesicle	ISO	J:155856
Cellular Component	GO:0005576	extracellular region	ISO	J:164563
Cellular Component	GO:0005615	extracellular space	HDA	J:221550
Cellular Component	GO:0005615	extracellular space	ISO	J:155856
Cellular Component	GO:0005615	extracellular space	IBA	J:265628
Cellular Component	GO:0005615	extracellular space	IDA	J:232381
Cellular Component	GO:0005615	extracellular space	IDA	J:193599
Cellular Component	GO:0005615	extracellular space	IDA	J:239875
Cellular Component	GO:0005615	extracellular space	IDA	J:208236
Cellular Component	GO:0005615	extracellular space	IDA	J:147177
Cellular Component	GO:0043025	neuronal cell body	ISO	J:155856
Cellular Component	GO:0043204	perikaryon	ISO	J:155856
Cellular Component	GO:0048471	perinuclear region of cytoplasm	ISO	J:155856
Cellular Component	GO:0005791	rough endoplasmic reticulum	ISO	J:155856
Cellular Component	GO:0045202	synapse	ISO	J:155856
Biological Process	GO:0001525	angiogenesis	TAS	J:169885
Biological Process	GO:0043615	astrocyte cell migration	ISO	J:164563
Biological Process	GO:0071347	cellular response to interleukin-1	IDA	J:118487
Biological Process	GO:0071347	cellular response to interleukin-1	IBA	J:265628
Biological Process	GO:0071222	cellular response to lipopolysaccharide	IDA	J:118487
Biological Process	GO:0071407	cellular response to organic cyclic compound	ISO	J:164563
Biological Process	GO:0071356	cellular response to tumor necrosis factor	IDA	J:118487
Biological Process	GO:0071356	cellular response to tumor necrosis factor	IBA	J:265628
Biological Process	GO:0071346	cellular response to type II interferon	IDA	J:118487
Biological Process	GO:0071346	cellular response to type II interferon	IBA	J:265628
Biological Process	GO:0070098	chemokine-mediated signaling pathway	ISO	J:155856
Biological Process	GO:0070098	chemokine-mediated signaling pathway	IBA	J:265628
Biological Process	GO:0006935	chemotaxis	IEA	J:60000
Biological Process	GO:0019221	cytokine-mediated signaling pathway	ISO	J:164563
Biological Process	GO:0019221	cytokine-mediated signaling pathway	ISO	J:155856
Biological Process	GO:0007010	cytoskeleton organization	ISO	J:164563
Biological Process	GO:0048245	eosinophil chemotaxis	IBA	J:265628
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	IBA	J:265628
Biological Process	GO:0008347	glial cell migration	ISO	J:155856
Biological Process	GO:0035684	helper T cell extravasation	IDA	J:140232
Biological Process	GO:0006955	immune response	IEA	J:72247
Biological Process	GO:0006954	inflammatory response	ISO	J:164563
Biological Process	GO:0006954	inflammatory response	IBA	J:265628
Biological Process	GO:0006874	intracellular calcium ion homeostasis	ISO	J:155856
Biological Process	GO:0002523	leukocyte migration involved in inflammatory response	ISO	J:155856
Biological Process	GO:0031663	lipopolysaccharide-mediated signaling pathway	ISO	J:164563
Biological Process	GO:0048247	lymphocyte chemotaxis	ISO	J:155856
Biological Process	GO:0048247	lymphocyte chemotaxis	IBA	J:265628
Biological Process	GO:0048246	macrophage chemotaxis	ISO	J:155856
Biological Process	GO:0048246	macrophage chemotaxis	ISO	J:164563
Biological Process	GO:0000165	MAPK cascade	ISO	J:164563
Biological Process	GO:0002548	monocyte chemotaxis	ISO	J:164563
Biological Process	GO:0002548	monocyte chemotaxis	IBA	J:265628
Biological Process	GO:0035702	monocyte homeostasis	TAS	J:169885
Biological Process	GO:0016525	negative regulation of angiogenesis	IMP	J:147328
Biological Process	GO:2000134	negative regulation of G1/S transition of mitotic cell cycle	ISO	J:164563
Biological Process	GO:0034351	negative regulation of glial cell apoptotic process	ISO	J:164563
Biological Process	GO:2000502	negative regulation of natural killer cell chemotaxis	ISO	J:164563
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	ISO	J:164563
Biological Process	GO:1905563	negative regulation of vascular endothelial cell proliferation	ISO	J:164563
Biological Process	GO:0030593	neutrophil chemotaxis	ISO	J:155856
Biological Process	GO:0030593	neutrophil chemotaxis	IBA	J:265628
Biological Process	GO:2000427	positive regulation of apoptotic cell clearance	IDA	J:170006
Biological Process	GO:0090280	positive regulation of calcium ion import	ISO	J:164563
Biological Process	GO:0045785	positive regulation of cell adhesion	ISO	J:155856
Biological Process	GO:0022409	positive regulation of cell-cell adhesion	ISO	J:155856
Biological Process	GO:0002693	positive regulation of cellular extravasation	ISO	J:155856
Biological Process	GO:0032967	positive regulation of collagen biosynthetic process	ISO	J:155856
Biological Process	GO:2000353	positive regulation of endothelial cell apoptotic process	ISO	J:164563
Biological Process	GO:0001938	positive regulation of endothelial cell proliferation	ISO	J:155856
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	IBA	J:265628
Biological Process	GO:0010628	positive regulation of gene expression	IMP	J:273531
Biological Process	GO:0043547	positive regulation of GTPase activity	IBA	J:265628
Biological Process	GO:0090265	positive regulation of immune complex clearance by monocytes and macrophages	IMP	J:147328
Biological Process	GO:0001912	positive regulation of leukocyte mediated cytotoxicity	ISO	J:155856
Biological Process	GO:0002687	positive regulation of leukocyte migration	ISO	J:155856
Biological Process	GO:0010759	positive regulation of macrophage chemotaxis	ISO	J:155856
Biological Process	GO:0010759	positive regulation of macrophage chemotaxis	IDA	J:147328
Biological Process	GO:0090026	positive regulation of monocyte chemotaxis	ISO	J:155856
Biological Process	GO:0090026	positive regulation of monocyte chemotaxis	IDA	J:220493
Biological Process	GO:0051770	positive regulation of nitric-oxide synthase biosynthetic process	IMP	J:169983
Biological Process	GO:1904783	positive regulation of NMDA glutamate receptor activity	ISO	J:155856
Biological Process	GO:0090314	positive regulation of protein targeting to membrane	ISO	J:155856
Biological Process	GO:0050806	positive regulation of synaptic transmission	ISO	J:155856
Biological Process	GO:0051968	positive regulation of synaptic transmission, glutamatergic	IDA	J:269680
Biological Process	GO:0050870	positive regulation of T cell activation	IMP	J:118487
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	ISO	J:155856
Biological Process	GO:0090303	positive regulation of wound healing	ISO	J:155856
Biological Process	GO:0043491	protein kinase B signaling	ISO	J:164563
Biological Process	GO:0008360	regulation of cell shape	ISO	J:164563
Biological Process	GO:0010574	regulation of vascular endothelial growth factor production	IMP	J:147328
Biological Process	GO:0009617	response to bacterium	IEP	J:190322
Biological Process	GO:0009408	response to heat	ISO	J:155856
Biological Process	GO:0009611	response to wounding	IDA	J:148250
Biological Process	GO:0019233	sensory perception of pain	IDA	J:269680
Biological Process	GO:0007179	transforming growth factor beta receptor signaling pathway	ISO	J:155856
Biological Process	GO:0048010	vascular endothelial growth factor receptor signaling pathway	ISO	J:155856