GO curators for mouse genes have assigned the following annotations to the gene product of Rmrp. (This text reflects annotations as of Wednesday, January 23, 2013.) MGI curation of this mouse gene is considered complete, including annotations derived from the biomedical literature as of June 26, 2007. If you know of any additional information regarding this mouse gene please let us know. Please supply mouse gene symbol and a PubMed ID.Summary from NCBI RefSeq
[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes the RNA component of mitochondrial RNA processing endoribonuclease, which cleaves mitochondrial RNA at a priming site of mitochondrial DNA replication. This RNA also interacts with the telomerase reverse transcriptase catalytic subunit to form a distinct ribonucleoprotein complex that has RNA-dependent RNA polymerase activity and produces double-stranded RNAs that can be processed into small interfering RNA. Mutations in this gene are associated with cartilage-hair hypoplasia.[provided by RefSeq, Mar 2010]Summary text based on GO annotations supported by experimental evidence in mouse
Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Rmrp
participates in the following biological processes:
Annotations directly to molecular function and cellular component for the gene Rmrp indicate that MGI curators have found no experimental data [literature] to support further annotation to these categories at this time.
References
Rosenbluh J et al. (2011) RMRP Is a Non-Coding RNA Essential for Early Murine Development. PLoS One, 6:e26270. (PubMed:22039455)
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