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Gene Ontology Classifications
retinoic acid receptor, alpha

Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Rara. (This text reflects annotations as of Tuesday, May 26, 2015.)
Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene represents a nuclear retinoic acid receptor. The encoded protein, retinoic acid receptor alpha, regulates transcription in a ligand-dependent manner. This gene has been implicated in regulation of development, differentiation, apoptosis, granulopoeisis, and transcription of clock genes. Translocations between this locus and several other loci have been associated with acute promyelocytic leukemia. Alternatively spliced transcript variants have been found for this locus.[provided by RefSeq, Sep 2010]
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by experimental evidence in other organisms
Summary text based on GO annotations supported by structural data
Summary text for additional MGI annotations
  1. Batourina E et al. (2002) Distal ureter morphogenesis depends on epithelial cell remodeling mediated by vitamin A and Ret. Nat Genet, 32:109-15. (PubMed:12195422)
  2. Ben-Shushan E et al. (1995) A dynamic balance between ARP-1/COUP-TFII, EAR-3/COUP-TFI, and retinoic acid receptor:retinoid X receptor heterodimers regulates Oct-3/4 expression in embryonal carcinoma cells. Mol Cell Biol, 15:1034-48. (PubMed:7823919)
  3. Braun KW et al. (2002) Positive regulation of retinoic Acid receptor alpha by protein kinase C and mitogen-activated protein kinase in sertoli cells. Biol Reprod, 67:29-37. (PubMed:12079996)
  4. Bruck N et al. (2009) A coordinated phosphorylation cascade initiated by p38MAPK/MSK1 directs RARalpha to target promoters. EMBO J, 28:34-47. (PubMed:19078967)
  5. Chen CF et al. (2005) Dominant-negative retinoic acid receptors elicit epidermal defects through a non-canonical pathway. J Biol Chem, 280:3012-21. (PubMed:15528198)
  6. Chen N et al. (2008) The nuclear transcription factor RARalpha associates with neuronal RNA granules and suppresses translation. J Biol Chem, 283:20841-7. (PubMed:18495661)
  7. Chung SS et al. (2005) Male sterility in mice lacking retinoic acid receptor alpha involves specific abnormalities in spermiogenesis. Differentiation, 73:188-98. (PubMed:15901285)
  8. Doyle TJ et al. (2007) Potential functions of retinoic acid receptor A in Sertoli cells and germ cells during spermatogenesis. Ann N Y Acad Sci, 1120:114-30. (PubMed:17905941)
  9. Flajollet S et al. (2006) Distinct roles of the steroid receptor coactivator 1 and of MED1 in retinoid-induced transcription and cellular differentiation. J Biol Chem, 281:20338-48. (PubMed:16723356)
  10. Ghyselinck NB et al. (1998) Contribution of retinoic acid receptor beta isoforms to the formation of the conotruncal septum of the embryonic heart. Dev Biol, 198:303-18. (PubMed:9659935)
  11. Greiner EF et al. (2000) Differential ligand-dependent protein-protein interactions between nuclear receptors and a neuronal-specific cofactor. Proc Natl Acad Sci U S A, 97:7160-5. (PubMed:10860982)
  12. Horlein AJ et al. (1995) Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor co-repressor [see comments] Nature, 377:397-404. (PubMed:7566114)
  13. Hou J et al. (2014) A regulatory network controls nephrocan expression and midgut patterning. Development, 141:3772-81. (PubMed:25209250)
  14. Jepsen K et al. (2007) SMRT-mediated repression of an H3K27 demethylase in progression from neural stem cell to neuron. Nature, 450:415-9. (PubMed:17928865)
  15. Kastner P et al. (2001) Positive and negative regulation of granulopoiesis by endogenous RARalpha. Blood, 97:1314-20. (PubMed:11222375)
  16. Kastner P et al. (1997) Vitamin A deficiency and mutations of RXRalpha, RXRbeta and RARalpha lead to early differentiation of embryonic ventricular cardiomyocytes. Development, 124:4749-58. (PubMed:9428411)
  17. Khetchoumian K et al. (2004) TIF1delta, a novel HP1-interacting member of the transcriptional intermediary factor 1 (TIF1) family expressed by elongating spermatids. J Biol Chem, 279:48329-41. (PubMed:15322135)
  18. Khetchoumian K et al. (2007) Loss of Trim24 (Tif1alpha) gene function confers oncogenic activity to retinoic acid receptor alpha. Nat Genet, 39:1500-6. (PubMed:18026104)
  19. Komori R et al. (2013) Csn3 gene is regulated by all-trans retinoic acid during neural differentiation in mouse P19 cells. PLoS One, 8:e61938. (PubMed:23613978)
  20. Le Douarin B et al. (1996) A possible involvement of TIF1 alpha and TIF1 beta in the epigenetic control of transcription by nuclear receptors. EMBO J, 15:6701-15. (PubMed:8978696)
  21. Lee CH et al. (1999) Characterization of receptor-interacting protein 140 in retinoid receptor activities. J Biol Chem, 274:31320-6. (PubMed:10531331)
  22. Lee HK et al. (2007) MED25 is distinct from TRAP220/MED1 in cooperating with CBP for retinoid receptor activation. EMBO J, 26:3545-57. (PubMed:17641689)
  23. Lohnes D et al. (1994) Function of the retinoic acid receptors (RARs) during development (I). Craniofacial and skeletal abnormalities in RAR double mutants. Development, 120:2723-48. (PubMed:7607067)
  24. Lufkin T et al. (1993) High postnatal lethality and testis degeneration in retinoic acid receptor alpha mutant mice. Proc Natl Acad Sci U S A, 90:7225-9. (PubMed:8394014)
  25. Maitra U et al. (2009) An innate immunity signaling process suppresses macrophage ABCA1 expression through IRAK-1-mediated downregulation of retinoic acid receptor alpha and NFATc2. Mol Cell Biol, 29:5989-97. (PubMed:19752193)
  26. Makita T et al. (2005) Retinoic acid, hypoxia, and GATA factors cooperatively control the onset of fetal liver erythropoietin expression and erythropoietic differentiation. Dev Biol, 280:59-72. (PubMed:15766748)
  27. Perissi V et al. (2004) A corepressor/coactivator exchange complex required for transcriptional activation by nuclear receptors and other regulated transcription factors. Cell, 116:511-26. (PubMed:14980219)
  28. Potter GB et al. (2001) The hairless gene mutated in congenital hair loss disorders encodes a novel nuclear receptor corepressor. Genes Dev, 15:2687-701. (PubMed:11641275)
  29. Rochette-Egly C et al. (1991) Retinoic acid receptor gamma: specific immunodetection and phosphorylation. J Cell Biol, 115:535-45. (PubMed:1655807)
  30. Shindo T et al. (2002) Kruppel-like zinc-finger transcription factor KLF5/BTEB2 is a target for angiotensin II signaling and an essential regulator of cardiovascular remodeling. Nat Med, 8:856-63. (PubMed:12101409)
  31. Subbarayan V et al. (1997) Limited specificity and large overlap of the functions of the mouse RAR gamma 1 and RAR gamma 2 isoforms. Mech Dev, 66:131-42. (PubMed:9376317)
  32. Sylvester I et al. (1994) Regulation of the Oct-4 gene by nuclear receptors. Nucleic Acids Res, 22:901-11. (PubMed:8152920)
  33. Weston AD et al. (2000) Regulation of skeletal progenitor differentiation by the BMP and retinoid signaling pathways. J Cell Biol, 148:679-90. (PubMed:10684250)
  34. Williams JA et al. (2009) Retinoic acid receptors are required for skeletal growth, matrix homeostasis and growth plate function in postnatal mouse. Dev Biol, 328:315-27. (PubMed:19389355)

Go Annotations in Tabular Form (Text View) (GO Graph)

Filter Markers by: Category  Evidence Code 


Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IAS Inferred from ancestral sequence
  IBA Inferred from biological aspect of ancestor
  IBD Inferred from biological aspect of descendant
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IKR Inferred from key residues
  IMP Inferred from mutant phenotype
  IMR Inferred from missing residues
  IPI Inferred from physical interaction
  IRD Inferred from rapid divergence
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


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