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Gene Ontology Classifications
Symbol
Name
ID
Ptprc
protein tyrosine phosphatase, receptor type, C
MGI:97810

Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Ptprc. (This text reflects annotations as of Thursday, July 24, 2014.)
Summary from NCBI RefSeq


[Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitosis, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus is classified as a receptor type PTP. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported. [provided by RefSeq, Jun 2012]
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by experimental evidence in other organisms
Summary text based on GO annotations supported by structural data
Summary text for additional MGI annotations
References
  1. Ait-Azzouzene D et al. (2001) Transgenic major histocompatibility complex class i antigen expressed in mouse trophoblast affects maternal immature b cells. Biol Reprod, 65:337-44. (PubMed:11466198)
  2. Arendt CW et al. (1997) Identification of the CD45-associated 116-kDa and 80-kDa proteins as the alpha- and beta-subunits of alpha-glucosidase II. J Biol Chem, 272:13117-25. (PubMed:9148925)
  3. Bachmann MF et al. (1997) T-cell-independent antiviral B cell responses in CD45-deficient mice. Cell Immunol, 175:12-5. (PubMed:9015183)
  4. Baker M et al. (2000) Development of T-leukaemias in CD45 tyrosine phosphatase-deficient mutant lck mice EMBO J, 19:4644-54. (PubMed:10970857)
  5. Balamuth F et al. (2004) CD4 raft association and signaling regulate molecular clustering at the immunological synapse site. J Immunol, 172:5887-92. (PubMed:15128768)
  6. Bultman SJ et al. (2005) A Brg1 mutation that uncouples ATPase activity from chromatin remodeling reveals an essential role for SWI/SNF-related complexes in beta-globin expression and erythroid development. Genes Dev, 19:2849-61. (PubMed:16287714)
  7. Burns CM et al. (1994) CD45 regulation of tyrosine phosphorylation and enzyme activity of src family kinases. J Biol Chem, 269:13594-600. (PubMed:8175795)
  8. Byth KF et al. (1996) CD45-null transgenic mice reveal a positive regulatory role for CD45 in early thymocyte development, in the selection of CD4+CD8+ thymocytes, and B cell maturation. J Exp Med, 183:1707-18. (PubMed:8666928)
  9. Carlyle JR et al. (2004) Missing self-recognition of Ocil/Clr-b by inhibitory NKR-P1 natural killer cell receptors. Proc Natl Acad Sci U S A, 101:3527-32. (PubMed:14990792)
  10. Cheng AM et al. (1995) Syk tyrosine kinase required for mouse viability and B-cell development. Nature, 378:303-6. (PubMed:7477353)
  11. Coombe DR et al. (1994) Mac-1 (CD11b/CD18) and CD45 mediate the adhesion of hematopoietic progenitor cells to stromal cell elements via recognition of stromal heparan sulfate. Blood, 84:739-52. (PubMed:8043862)
  12. Cyster JG et al. (1996) Regulation of B-lymphocyte negative and positive selection by tyrosine phosphatase CD45. Nature, 381:325-8. (PubMed:8692271)
  13. Davidson WF et al. (1984) Dissociation of severe lupus-like disease from polyclonal B cell activation and IL 2 deficiency in C3H-lpr/lpr mice. J Immunol, 133:1048-56. (PubMed:6610701)
  14. de Yebenes VG et al. (2008) miR-181b negatively regulates activation-induced cytidine deaminase in B cells. J Exp Med, 205:2199-206. (PubMed:18762567)
  15. Du C et al. (2009) MicroRNA miR-326 regulates TH-17 differentiation and is associated with the pathogenesis of multiple sclerosis. Nat Immunol, 10:1252-9. (PubMed:19838199)
  16. Erlandsson L et al. (2005) Both the pre-BCR and the IL-7Ralpha are essential for expansion at the pre-BII cell stage in vivo. Eur J Immunol, 35:1969-1976. (PubMed:15909309)
  17. Ferkowicz MJ et al. (2003) CD41 expression defines the onset of primitive and definitive hematopoiesis in the murine embryo. Development, 130:4393-403. (PubMed:12900455)
  18. Fujiwara H et al. (1994) The absence of IgE antibody-mediated augmentation of immune responses in CD23-deficient mice. Proc Natl Acad Sci U S A, 91:6835-9. (PubMed:8041705)
  19. Gartlan KH et al. (2010) A complementary role for the tetraspanins CD37 and Tssc6 in cellular immunity. J Immunol, 185:3158-66. (PubMed:20709950)
  20. Haidl ID et al. (1995) Detection of restricted isoform expression and tyrosine phosphatase activity of CD45 in murine dendritic cells. Eur J Immunol, 25:3370-4. (PubMed:8566025)
  21. Hanaoka K et al. (1995) Involvement of CD45 in adhesion and suppression of apoptosis of mouse malignant T-lymphoma cells. Cancer Res, 55:2186-90. (PubMed:7743522)
  22. Harp JA et al. (1984) Inhibition of T cell responses to alloantigens and polyclonal mitogens by Ly-5 antisera. J Immunol, 133:10-5. (PubMed:6233370)
  23. Hervas-Stubbs S et al. (2007) Insect baculoviruses strongly potentiate adaptive immune responses by inducing type I IFN. J Immunol, 178:2361-9. (PubMed:17277142)
  24. Hosoya T et al. (2009) GATA-3 is required for early T lineage progenitor development. J Exp Med, 206:2987-3000. (PubMed:19934022)
  25. Irie-Sasaki J et al. (2001) CD45 is a JAK phosphatase and negatively regulates cytokine receptor signalling. Nature, 409:349-54. (PubMed:11201744)
  26. Katagiri T et al. (1995) Selective regulation of Lyn tyrosine kinase by CD45 in immature B cells. J Biol Chem, 270:27987-90. (PubMed:7499277)
  27. Kawai K et al. (1995) Impaired development of V gamma 3 dendritic epidermal T cells in p56lck protein tyrosine kinase-deficient and CD45 protein tyrosine phosphatase-deficient mice. J Exp Med, 181:345-9. (PubMed:7807014)
  28. Kina T et al. (2000) The monoclonal antibody TER-119 recognizes a molecule associated with glycophorin A and specifically marks the late stages of murine erythroid lineage. Br J Haematol, 109:280-7. (PubMed:10848813)
  29. Kishihara K et al. (1993) Normal B lymphocyte development but impaired T cell maturation in CD45-exon6 protein tyrosine phosphatase-deficient mice. Cell, 74:143-56. (PubMed:8334701)
  30. Kong YY et al. (1995) Generation of T cells with differential responses to alloantigens in CD45 exon 6-deficient mice. J Immunol, 154:5725-35. (PubMed:7751624)
  31. Kong YY et al. (1995) Differential requirements of CD45 for lymphocyte development and function. Eur J Immunol, 25:3431-6. (PubMed:8566034)
  32. Krasteva G et al. (2011) Cholinergic chemosensory cells in the trachea regulate breathing. Proc Natl Acad Sci U S A, 108:9478-83. (PubMed:21606356)
  33. Lee JM et al. (1996) Association of CD45 with Lck and components of the Ras signalling pathway in pervanadate-treated mouse T-cell lines. Oncogene, 12:253-63. (PubMed:8570203)
  34. Li T et al. (1996) Distinct patterns of Fas cell surface expression during development of T- or B-lymphocyte lineages in normal, scid, and mutant mice lacking or overexpressing p53, bcl-2, or rag-2 genes. Cell Growth Differ, 7:107-14. (PubMed:8788039)
  35. Matsuzaki J et al. (2003) Successful elimination of memory-type CD8+ T cell subsets by the administration of anti-Gr-1 monoclonal antibody in vivo. Cell Immunol, 224:98-105. (PubMed:14609575)
  36. Mee PJ et al. (1999) Greatly reduced efficiency of both positive and negative selection of thymocytes in CD45 tyrosine phosphatase-deficient mice. Eur J Immunol, 29:2923-33. (PubMed:10508267)
  37. Motomura Y et al. (2011) The transcription factor E4BP4 regulates the production of IL-10 and IL-13 in CD4+ T cells. Nat Immunol, 12:450-9. (PubMed:21460847)
  38. Nagamachi A et al. (2013) Haploinsufficiency of SAMD9L, an endosome fusion facilitator, causes myeloid malignancies in mice mimicking human diseases with monosomy 7. Cancer Cell, 24:305-17. (PubMed:24029230)
  39. Negishi I et al. (1995) Essential role for ZAP-70 in both positive and negative selection of thymocytes. Nature, 376:435-8. (PubMed:7630421)
  40. Nemeth MJ et al. (2003) Hmgb3: an HMG-box family member expressed in primitive hematopoietic cells that inhibits myeloid and B-cell differentiation. Blood, 102:1298-306. (PubMed:12714519)
  41. Ng DH et al. (1997) CD45 and RPTPalpha display different protein tyrosine phosphatase activities in T lymphocytes. Biochem J, 327:867-76. (PubMed:9581568)
  42. Ng LG et al. (2004) B cell-activating factor belonging to the TNF family (BAFF)-R is the principal BAFF receptor facilitating BAFF costimulation of circulating T and B cells. J Immunol, 173:807-17. (PubMed:15240667)
  43. Nowell CS et al. (2011) Foxn1 regulates lineage progression in cortical and medullary thymic epithelial cells but is dispensable for medullary sublineage divergence. PLoS Genet, 7:e1002348. (PubMed:22072979)
  44. O'Connell RM et al. (2010) MicroRNAs enriched in hematopoietic stem cells differentially regulate long-term hematopoietic output. Proc Natl Acad Sci U S A, 107:14235-40. (PubMed:20660734)
  45. Ogilvy S et al. (2003) Either of the CD45RB and CD45RO isoforms are effective in restoring T cell, but not B cell, development and function in CD45-null mice. J Immunol, 171:1792-800. (PubMed:12902479)
  46. Pani G et al. (1997) The motheaten mutation rescues B cell signaling and development in CD45-deficient mice. J Exp Med, 186:581-8. (PubMed:9254656)
  47. Park H et al. (2008) A point mutation in the murine Hem1 gene reveals an essential role for Hematopoietic Protein 1 in lymphopoiesis and innate immunity. J Exp Med, 205:2899-913. (PubMed:19015308)
  48. Roach T et al. (1997) CD45 regulates Src family member kinase activity associated with macrophage integrin-mediated adhesion. Curr Biol, 7:408-17. (PubMed:9197241)
  49. Rupec RA et al. (2005) Stroma-mediated dysregulation of myelopoiesis in mice lacking I kappa B alpha. Immunity, 22:479-91. (PubMed:15845452)
  50. Scaglione BJ et al. (2007) Murine models of chronic lymphocytic leukaemia: role of microRNA-16 in the New Zealand Black mouse model. Br J Haematol, 139:645-57. (PubMed:17941951)
  51. Schenten D et al. (2006) M17, a gene specific for germinal center (GC) B cells and a prognostic marker for GC B-cell lymphomas, is dispensable for the GC reaction in mice. Blood, 107:4849-56. (PubMed:16493007)
  52. Seavitt JR et al. (1999) Expression of the p56(Lck) Y505F mutation in CD45-deficient mice rescues thymocyte development. Mol Cell Biol, 19:4200-8. (PubMed:10330160)
  53. Shahinian A et al. (1993) Differential T cell costimulatory requirements in CD28-deficient mice. Science, 261:609-12. (PubMed:7688139)
  54. Simpson SJ et al. (1995) Evidence that CD4+, but not CD8+ T cells are responsible for murine interleukin-2-deficient colitis. Eur J Immunol, 25:2618-25. (PubMed:7589135)
  55. Takai T et al. (1996) Augmented humoral and anaphylactic responses in Fc gamma RII-deficient mice. Nature, 379:346-9. (PubMed:8552190)
  56. Takayanagi S et al. (2006) Genetic marking of hematopoietic stem and endothelial cells: identification of the Tmtsp gene encoding a novel cell surface protein with the thrombospondin-1 domain. Blood, 107:4317-25. (PubMed:16455951)
  57. Tamura K et al. (2000) Requirement for p38alpha in erythropoietin expression: a role for stress kinases in erythropoiesis Cell, 102:221-31. (PubMed:10943842)
  58. Trowbridge IS et al. (1976) Immunological properties of murine thymus-dependent lymphocyte surface glycoproteins. Eur J Immunol, 6:557-62. (PubMed:61878)
  59. Turner M et al. (1995) Perinatal lethality and blocked B-cell development in mice lacking the tyrosine kinase Syk. Nature, 378:298-302. (PubMed:7477352)
  60. Wang R et al. (2008) Identification of a regulatory T cell specific cell surface molecule that mediates suppressive signals and induces Foxp3 expression. PLoS ONE, 3:e2705. (PubMed:18628982)
  61. Wiest DL et al. (1997) A spontaneously arising mutation in the DLAARN motif of murine ZAP-70 abrogates kinase activity and arrests thymocyte development. Immunity, 6:663-71. (PubMed:9208839)
  62. Winkler IG et al. (2005) Serine protease inhibitors serpina1 and serpina3 are down-regulated in bone marrow during hematopoietic progenitor mobilization. J Exp Med, 201:1077-88. (PubMed:15795238)
  63. Yada S et al. (1998) Differential requirements of CD45 protein tyrosine phosphatase for cytolytic activities and intrathymic and extrathymic development of intestinal intraepithelial lymphocytes. J Immunol, 161:2208-16. (PubMed:9725213)



Go Annotations in Tabular Form (Text View) (GO Graph)

 
 


Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IMP Inferred from mutant phenotype
  IPI Inferred from physical interaction
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory