Automated description from the Alliance of Genome Resources (Release 3.1.1)
Exhibits several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; E-box binding activity; and arachidonic acid binding activity. Predicted to contribute to sequence-specific DNA binding activity. Involved in several processes, including brown fat cell differentiation; cellular response to lithium ion; and regulation of transcription by RNA polymerase II. Localizes to cytosol and nucleus. Is expressed in several structures, including adipose tissue; alimentary system; genitourinary system; musculoskeletal system; and nervous system. Used to study abdominal obesity-metabolic syndrome; congenital generalized lipodystrophy type 2; familial partial lipodystrophy; primary pulmonary hypertension; and systemic lupus erythematosus. Human ortholog(s) of this gene implicated in several diseases, including cardiovascular system disease (multiple); end stage renal disease; familial combined hyperlipidemia; lipodystrophy (multiple); and obesity. Orthologous to human PPARG (peroxisome proliferator activated receptor gamma).