About   Help   FAQ
Gene Ontology Classifications
Symbol
Name
ID
Pparg
peroxisome proliferator activated receptor gamma
MGI:97747

Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Pparg. (This text reflects annotations as of Thursday, July 24, 2014.)
Summary from NCBI RefSeq


[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) subfamily of nuclear receptors. PPARs form heterodimers with retinoid X receptors (RXRs) and these heterodimers regulate transcription of various genes. Three subtypes of PPARs are known: PPAR-alpha, PPAR-delta, and PPAR-gamma. The protein encoded by this gene is PPAR-gamma and is a regulator of adipocyte differentiation. Additionally, PPAR-gamma has been implicated in the pathology of numerous diseases including obesity, diabetes, atherosclerosis and cancer. Alternatively spliced transcript variants that encode different isoforms have been described. [provided by RefSeq, Jul 2008]
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by experimental evidence in other organisms
Summary text based on GO annotations supported by structural data
Summary text for additional MGI annotations
References
  1. . () , :. (PubMed:)
  2. Bennett CN et al. (2002) Regulation of Wnt signaling during adipogenesis. J Biol Chem, 277:30998-1004. (PubMed:12055200)
  3. Bennett CN et al. (2005) Regulation of osteoblastogenesis and bone mass by Wnt10b. Proc Natl Acad Sci U S A, 102:3324-9. (PubMed:15728361)
  4. Bonfield TL et al. (2008) Peroxisome proliferator-activated receptor-gamma regulates the expression of alveolar macrophage macrophage colony-stimulating factor. J Immunol, 181:235-42. (PubMed:18566389)
  5. Buyse M et al. (2001) Insulin and glucocorticoids differentially regulate leptin transcription and secretion in brown adipocytes. FASEB J, 15:1357-66. (PubMed:11387233)
  6. Drori S et al. (2005) Hic-5 regulates an epithelial program mediated by PPARgamma. Genes Dev, 19:362-75. (PubMed:15687259)
  7. Fan M et al. (2004) Suppression of mitochondrial respiration through recruitment of p160 myb binding protein to PGC-1alpha: modulation by p38 MAPK. Genes Dev, 18:278-89. (PubMed:14744933)
  8. Fei Z et al. (2011) Ankrd26 gene disruption enhances adipogenesis of mouse embryonic fibroblasts. J Biol Chem, 286:27761-8. (PubMed:21669876)
  9. Ge K et al. (2002) Transcription coactivator TRAP220 is required for PPAR gamma 2-stimulated adipogenesis. Nature, 417:563-7. (PubMed:12037571)
  10. Girnun GD et al. (2002) APC-dependent suppression of colon carcinogenesis by PPARgamma. Proc Natl Acad Sci U S A, 99:13771-6. (PubMed:12370429)
  11. Gray S et al. (2002) The Kruppel-like factor KLF15 regulates the insulin-sensitive glucose transporter GLUT4. J Biol Chem, 277:34322-8. (PubMed:12097321)
  12. Grimaldi B et al. (2010) PER2 controls lipid metabolism by direct regulation of PPARgamma. Cell Metab, 12:509-20. (PubMed:21035761)
  13. Guan HP et al. (2005) Corepressors selectively control the transcriptional activity of PPARgamma in adipocytes. Genes Dev, 19:453-61. (PubMed:15681609)
  14. Guthmann F et al. (2004) Phenotype of palmitic acid transport and of signalling in alveolar type II cells from E/H-FABP double-knockout mice: contribution of caveolin-1 and PPARgamma. Biochim Biophys Acta, 1636:196-204. (PubMed:15164767)
  15. Hong JH et al. (2005) TAZ, a transcriptional modulator of mesenchymal stem cell differentiation. Science, 309:1074-8. (PubMed:16099986)
  16. Ichida F et al. (2004) Reciprocal roles of MSX2 in regulation of osteoblast and adipocyte differentiation. J Biol Chem, 279:34015-22. (PubMed:15175325)
  17. Ji S et al. (2012) O-GlcNAc modification of PPARgamma reduces its transcriptional activity. Biochem Biophys Res Commun, 417:1158-63. (PubMed:22226965)
  18. Kawai M et al. (2010) A circadian-regulated gene, Nocturnin, promotes adipogenesis by stimulating PPAR-gamma nuclear translocation. Proc Natl Acad Sci U S A, 107:10508-13. (PubMed:20498072)
  19. Makowski L et al. (2005) The fatty acid-binding protein, aP2, coordinates macrophage cholesterol trafficking and inflammatory activity. Macrophage expression of aP2 impacts peroxisome proliferator-activated receptor gamma and IkappaB kinase activities. J Biol Chem, 280:12888-95. (PubMed:15684432)
  20. Nagy L et al. (1998) Oxidized LDL regulates macrophage gene expression through ligand activation of PPARgamma. Cell, 93:229-40. (PubMed:9568715)
  21. Nofsinger RR et al. (2008) SMRT repression of nuclear receptors controls the adipogenic set point and metabolic homeostasis. Proc Natl Acad Sci U S A, 105:20021-6. (PubMed:19066220)
  22. Ohoka N et al. (2009) The orphan nuclear receptor ROR{alpha} restrains adipocyte differentiation through a reduction of C/EBP{beta} activity and perilipin gene expression. Mol Endocrinol, 23:759-71. (PubMed:19324970)
  23. Pascual G et al. (2005) A SUMOylation-dependent pathway mediates transrepression of inflammatory response genes by PPAR-gamma. Nature, 437:759-63. (PubMed:16127449)
  24. Patsouris D et al. (2004) PPARalpha governs glycerol metabolism. J Clin Invest, 114:94-103. (PubMed:15232616)
  25. Perez-Mancera PA et al. (2007) Adipose tissue mass is modulated by SLUG (SNAI2). Hum Mol Genet, 16:2972-86. (PubMed:17905753)
  26. Picard F et al. (2004) Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-gamma. Nature, 429:771-6. (PubMed:15175761)
  27. Qiang L et al. (2012) Brown remodeling of white adipose tissue by SirT1-dependent deacetylation of Ppargamma. Cell, 150:620-32. (PubMed:22863012)
  28. Rajakumari S et al. (2013) EBF2 determines and maintains brown adipocyte identity. Cell Metab, 17:562-74. (PubMed:23499423)
  29. Ross SE et al. (2000) Inhibition of adipogenesis by Wnt signaling. Science, 289:950-3. (PubMed:10937998)
  30. Schaiff WT et al. (2007) Ligand-activated peroxisome proliferator activated receptor gamma alters placental morphology and placental fatty acid uptake in mice. Endocrinology, 148:3625-34. (PubMed:17463056)
  31. Seale P et al. (2008) PRDM16 controls a brown fat/skeletal muscle switch. Nature, 454:961-7. (PubMed:18719582)
  32. Shibuya A et al. (2002) Nitration of PPARgamma inhibits ligand-dependent translocation into the nucleus in a macrophage-like cell line, RAW 264. FEBS Lett, 525:43-7. (PubMed:12163159)
  33. Tang QQ et al. (2003) Mitotic clonal expansion: A synchronous process required for adipogenesis. Proc Natl Acad Sci U S A, 100:44-9. (PubMed:12502791)
  34. Tomaru T et al. (2006) Isolation and characterization of a transcriptional cofactor and its novel isoform that bind the deoxyribonucleic acid-binding domain of peroxisome proliferator-activated receptor-gamma. Endocrinology, 147:377-88. (PubMed:16239304)
  35. Vertino AM et al. (2005) Wnt10b deficiency promotes coexpression of myogenic and adipogenic programs in myoblasts. Mol Biol Cell, 16:2039-48. (PubMed:15673614)
  36. Wang F et al. (2009) SIRT2 suppresses adipocyte differentiation by deacetylating FOXO1 and enhancing FOXO1's repressive interaction with PPARgamma. Mol Biol Cell, 20:801-8. (PubMed:19037106)
  37. Wu Y et al. (2008) Wdnm1-like, a new adipokine with a role in MMP-2 activation. Am J Physiol Endocrinol Metab, 295:E205-15. (PubMed:18492766)
  38. Yamashita-Sugahara Y et al. (2013) Fam57b (family with sequence similarity 57, member B), a novel peroxisome proliferator-activated receptor gamma target gene that regulates adipogenesis through ceramide synthesis. J Biol Chem, 288:4522-37. (PubMed:23275342)
  39. Zhu Y et al. (1997) Isolation and characterization of PBP, a protein that interacts with peroxisome proliferator-activated receptor. J Biol Chem, 272:25500-6. (PubMed:9325263)



Go Annotations in Tabular Form (Text View) (GO Graph)

 
 


Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IMP Inferred from mutant phenotype
  IPI Inferred from physical interaction
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/09/2014
MGI 5.19
The Jackson Laboratory