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Gene Ontology Classifications
peroxisome proliferator activated receptor gamma

Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Pparg. (This text reflects annotations as of Tuesday, May 26, 2015.)
Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) subfamily of nuclear receptors. PPARs form heterodimers with retinoid X receptors (RXRs) and these heterodimers regulate transcription of various genes. Three subtypes of PPARs are known: PPAR-alpha, PPAR-delta, and PPAR-gamma. The protein encoded by this gene is PPAR-gamma and is a regulator of adipocyte differentiation. Additionally, PPAR-gamma has been implicated in the pathology of numerous diseases including obesity, diabetes, atherosclerosis and cancer. Alternatively spliced transcript variants that encode different isoforms have been described. [provided by RefSeq, Jul 2008]
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by experimental evidence in other organisms
Summary text based on GO annotations supported by structural data
Summary text for additional MGI annotations
  1. . () , :. (PubMed:)
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  11. Girnun GD et al. (2002) APC-dependent suppression of colon carcinogenesis by PPARgamma. Proc Natl Acad Sci U S A, 99:13771-6. (PubMed:12370429)
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  13. Grimaldi B et al. (2010) PER2 controls lipid metabolism by direct regulation of PPARgamma. Cell Metab, 12:509-20. (PubMed:21035761)
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  18. Ji S et al. (2012) O-GlcNAc modification of PPARgamma reduces its transcriptional activity. Biochem Biophys Res Commun, 417:1158-63. (PubMed:22226965)
  19. Kawai M et al. (2010) A circadian-regulated gene, Nocturnin, promotes adipogenesis by stimulating PPAR-gamma nuclear translocation. Proc Natl Acad Sci U S A, 107:10508-13. (PubMed:20498072)
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  21. Makowski L et al. (2005) The fatty acid-binding protein, aP2, coordinates macrophage cholesterol trafficking and inflammatory activity. Macrophage expression of aP2 impacts peroxisome proliferator-activated receptor gamma and IkappaB kinase activities. J Biol Chem, 280:12888-95. (PubMed:15684432)
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  30. Qiang L et al. (2012) Brown remodeling of white adipose tissue by SirT1-dependent deacetylation of Ppargamma. Cell, 150:620-32. (PubMed:22863012)
  31. Rajakumari S et al. (2013) EBF2 determines and maintains brown adipocyte identity. Cell Metab, 17:562-74. (PubMed:23499423)
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  33. Schaiff WT et al. (2007) Ligand-activated peroxisome proliferator activated receptor gamma alters placental morphology and placental fatty acid uptake in mice. Endocrinology, 148:3625-34. (PubMed:17463056)
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  35. Shibuya A et al. (2002) Nitration of PPARgamma inhibits ligand-dependent translocation into the nucleus in a macrophage-like cell line, RAW 264. FEBS Lett, 525:43-7. (PubMed:12163159)
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  43. Yamashita-Sugahara Y et al. (2013) Fam57b (family with sequence similarity 57, member B), a novel peroxisome proliferator-activated receptor gamma target gene that regulates adipogenesis through ceramide synthesis. J Biol Chem, 288:4522-37. (PubMed:23275342)
  44. Zhu Y et al. (1997) Isolation and characterization of PBP, a protein that interacts with peroxisome proliferator-activated receptor. J Biol Chem, 272:25500-6. (PubMed:9325263)

Go Annotations in Tabular Form (Text View) (GO Graph)

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Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IAS Inferred from ancestral sequence
  IBA Inferred from biological aspect of ancestor
  IBD Inferred from biological aspect of descendant
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IKR Inferred from key residues
  IMP Inferred from mutant phenotype
  IMR Inferred from missing residues
  IPI Inferred from physical interaction
  IRD Inferred from rapid divergence
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


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