Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Por. (This text reflects annotations as of Tuesday, May 21, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes an endoplasmic reticulum membrane oxidoreductase with an FAD-binding domain and a flavodoxin-like domain. The protein binds two cofactors, FAD and FMN, which allow it to donate electrons directly from NADPH to all microsomal P450 enzymes. Mutations in this gene have been associated with various diseases, including apparent combined P450C17 and P450C21 deficiency, amenorrhea and disordered steroidogenesis, congenital adrenal hyperplasia and Antley-Bixler syndrome. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Por
  • participates in the following biological processes:
    • oxidation-reduction process ^[1]
  • performs the following molecular functions:
    • oxidoreductase activity ^[1]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Por:
  • participates in the following biological processes:
    • cellular organofluorine metabolic process
    • demethylation
    • fatty acid oxidation
    • internal peptidyl-lysine acetylation
    • negative regulation of apoptotic process
    • negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
    • negative regulation of lipase activity
    • nitrate catabolic process
    • nitric oxide catabolic process
    • oxidation-reduction process
    • positive regulation of cholesterol biosynthetic process
    • positive regulation of chondrocyte differentiation
    • positive regulation of monooxygenase activity
    • positive regulation of smoothened signaling pathway
    • positive regulation of steroid hormone biosynthetic process
    • regulation of cholesterol metabolic process
    • regulation of growth plate cartilage chondrocyte proliferation
  • performs the following molecular functions:
    • cytochrome-b5 reductase activity, acting on NAD(P)H
    • electron carrier activity
    • enzyme binding
    • flavin adenine dinucleotide binding
    • FMN binding
    • hydrolase activity
    • iron-cytochrome-c reductase activity
    • NADP binding
    • NADPH-hemoprotein reductase activity
    • nitric oxide dioxygenase activity
    • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
  • is located in the following cellular components:
    • cytosol
    • intracellular membrane-bounded organelle
    • membrane
    • mitochondrion

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Summary text based on GO annotations supported by structural data

• Por encodes a protein or proteins that contain the following InterPro domains: FAD-binding, type 1, Ferredoxin reductase-type FAD-binding domain, Flavodoxin, Flavodoxin/nitric oxide synthase, Flavoprotein pyridine nucleotide cytochrome reductase, NADPH-cytochrome P450 reductase, NADPH-cytochrome p450 reductase, FAD-binding, alpha-helical domain-3, Oxidoreductase FAD/NAD(P)-binding, Riboflavin synthase-like beta-barrel, indicating that the gene product:
  • performs the following molecular functions:
    • iron ion binding

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Por indicates that it:
  • is located in the following cellular components:
    • endoplasmic reticulum

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References

1. Shen AL et al. (2002) Association of multiple developmental defects and embryonic lethality with loss of microsomal NADPH-cytochrome P450 oxidoreductase. J Biol Chem, 277:6536-41. (PubMed:11742006)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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