Automated description from the Alliance of Genome Resources
Exhibits several functions, including insulin receptor substrate binding activity; phosphatidylinositol 3-kinase regulatory subunit binding activity; and transcription factor binding activity. Predicted to contribute to 1-phosphatidylinositol-3-kinase activity. Involved in several processes, including apoptotic signaling pathway; negative regulation of osteoclast differentiation; and regulation of cellular protein localization. Localizes to several cellular components, including the cell-cell junction; cytoplasm; and nucleus. Used to study Bruton-type agammaglobulinemia. Human ortholog(s) of this gene implicated in several diseases, including astroblastoma; endometrial cancer (multiple); lung small cell carcinoma; primary immunodeficiency disease (multiple); and type 2 diabetes mellitus. Orthologous to human PIK3R1 (phosphoinositide-3-kinase regulatory subunit 1).