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Gene Ontology Classifications
phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha)

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GO curators for mouse genes have assigned the following annotations to the gene product of Pik3r1. (This text reflects annotations as of Tuesday, May 26, 2015.)
Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] Phosphatidylinositol 3-kinase phosphorylates the inositol ring of phosphatidylinositol at the 3-prime position. The enzyme comprises a 110 kD catalytic subunit and a regulatory subunit of either 85, 55, or 50 kD. This gene encodes the 85 kD regulatory subunit. Phosphatidylinositol 3-kinase plays an important role in the metabolic actions of insulin, and a mutation in this gene has been associated with insulin resistance. Alternative splicing of this gene results in four transcript variants encoding different isoforms. [provided by RefSeq, Jun 2011]
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by experimental evidence in other organisms
Summary text based on GO annotations supported by structural data
Summary text for additional MGI annotations
  1. Ahn E et al. (2006) LIME acts as a transmembrane adapter mediating BCR-dependent B-cell activation. Blood, 107:1521-7. (PubMed:16249387)
  2. Baki L et al. (2004) PS1 activates PI3K thus inhibiting GSK-3 activity and tau overphosphorylation: effects of FAD mutations. EMBO J, 23:2586-96. (PubMed:15192701)
  3. Beyer TA et al. (2008) Impaired liver regeneration in Nrf2 knockout mice: role of ROS-mediated insulin/IGF-1 resistance. EMBO J, 27:212-23. (PubMed:18059474)
  4. Cariaga-Martinez AE et al. (2014) Phosphoinositide 3-kinase p85beta regulates invadopodium formation. Biol Open, 3:924-36. (PubMed:25217619)
  5. Dubielecka PM et al. (2010) Abi1/Hssh3bp1 pY213 links Abl kinase signaling to p85 regulatory subunit of PI-3 kinase in regulation of macropinocytosis in LNCaP cells. FEBS Lett, 584:3279-86. (PubMed:20598684)
  6. Fransson S et al. (2012) p37delta is a new isoform of PI3K p110delta that increases cell proliferation and is overexpressed in tumors. Oncogene, 31:3277-86. (PubMed:22020336)
  7. Furuya F et al. (2007) Nuclear receptor corepressor is a novel regulator of phosphatidylinositol 3-kinase signaling. Mol Cell Biol, 27:6116-26. (PubMed:17606624)
  8. Hiatt K et al. (2004) Loss of the nf1 tumor suppressor gene decreases fas antigen expression in myeloid cells. Am J Pathol, 164:1471-9. (PubMed:15039234)
  9. Holgado-Madruga M et al. (2003) Gab1 is an integrator of cell death versus cell survival signals in oxidative stress. Mol Cell Biol, 23:4471-84. (PubMed:12808090)
  10. Krebs DL et al. (2002) SOCS-6 binds to insulin receptor substrate 4, and mice lacking the SOCS-6 gene exhibit mild growth retardation. Mol Cell Biol, 22:4567-78. (PubMed:12052866)
  11. Li Q et al. (2010) The density of extracellular matrix proteins regulates inflammation and insulin signaling in adipocytes. FEBS Lett, 584:4145-50. (PubMed:20804756)
  12. Liang Y et al. (2013) The lymphoid lineage-specific actin-uncapping protein Rltpr is essential for costimulation via CD28 and the development of regulatory T cells. Nat Immunol, 14:858-66. (PubMed:23793062)
  13. Luo J et al. (2005) The p85 regulatory subunit of phosphoinositide 3-kinase down-regulates IRS-1 signaling via the formation of a sequestration complex. J Cell Biol, 170:455-64. (PubMed:16043515)
  14. Okada T et al. (2000) BCAP: the tyrosine kinase substrate that connects B cell receptor to phosphoinositide 3-kinase activation. Immunity, 13:817-27. (PubMed:11163197)
  15. Papin J et al. (2004) Bioinformatics and cellular signaling. Curr Opin Biotechnol, 15:78-81. (PubMed:15102471)
  16. Park K et al. (2013) Serine phosphorylation sites on IRS2 activated by angiotensin II and protein kinase C to induce selective insulin resistance in endothelial cells. Mol Cell Biol, 33:3227-41. (PubMed:23775122)
  17. Park SW et al. (2010) The regulatory subunits of PI3K, p85alpha and p85beta, interact with XBP-1 and increase its nuclear translocation. Nat Med, 16:429-37. (PubMed:20348926)
  18. Riedel H et al. (2000) PSM, a mediator of PDGF-BB-, IGF-I-, and insulin-stimulated mitogenesis. Oncogene, 19:39-50. (PubMed:10644978)
  19. Song L et al. (2007) p85alpha acts as a novel signal transducer for mediation of cellular apoptotic response to UV radiation. Mol Cell Biol, 27:2713-31. (PubMed:17242187)
  20. Suzuki H et al. (2001) Protein-protein interaction panel using mouse full-length cDNAs. Genome Res, 11:1758-65. (PubMed:11591653)
  21. Terauchi Y et al. (1999) Increased insulin sensitivity and hypoglycaemia in mice lacking the P85 alpha subunit of phosphoinositide 3- kinase. Nat Genet, 21:230-235. (PubMed:9988280)
  22. Yang FC et al. (2006) Hyperactivation of p21 and PI3K cooperate to alter murine and human neurofibromatosis type 1-haploinsufficient osteoclast functions. J Clin Invest, 116:2880-91. (PubMed:17053831)
  23. Yokoyama K et al. (2011) NYAP: a phosphoprotein family that links PI3K to WAVE1 signalling in neurons. EMBO J, 30:4739-54. (PubMed:21946561)
  24. Yu WM et al. (2002) Role of the docking protein Gab2 in beta(1)-integrin signaling pathway-mediated hematopoietic cell adhesion and migration. Blood, 99:2351-9. (PubMed:11895767)

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Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IAS Inferred from ancestral sequence
  IBA Inferred from biological aspect of ancestor
  IBD Inferred from biological aspect of descendant
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IKR Inferred from key residues
  IMP Inferred from mutant phenotype
  IMR Inferred from missing residues
  IPI Inferred from physical interaction
  IRD Inferred from rapid divergence
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


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