Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Pik3r1. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] Phosphatidylinositol 3-kinase phosphorylates the inositol ring of phosphatidylinositol at the 3-prime position. The enzyme comprises a 110 kD catalytic subunit and a regulatory subunit of either 85, 55, or 50 kD. This gene encodes the 85 kD regulatory subunit. Phosphatidylinositol 3-kinase plays an important role in the metabolic actions of insulin, and a mutation in this gene has been associated with insulin resistance. Alternative splicing of this gene results in four transcript variants encoding different isoforms. [provided by RefSeq, Jun 2011]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Pik3r1
  • participates in the following biological processes:
    • negative regulation of apoptotic process ^[2]
    • protein phosphorylation ^[2]
  • is located in the following cellular components:
    • cytoplasm ^[6]
    • cytosol ^[6]
    • membrane ^[6]
• The gene product of Pik3r1 has been shown to bind to the gene products of Brd7, Eif4g2, Lime1, Ncor1, Pdgfrb, Pik3ca, Pik3cb, Psen1, Thrb. ^{[1, 2, 3, 5, 7, 8, 10, 13]} Researchers have inferred, based on physical interactions, that the gene product of Pik3r1
  • performs the following molecular functions:
    • insulin receptor substrate binding ^[6]
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Pik3r1
  • participates in the following biological processes:
    • B cell differentiation ^[11]
    • cellular response to UV ^[9]
    • NFAT protein import into nucleus ^[9]
    • positive regulation of apoptotic process ^[9]
    • positive regulation of transcription from RNA polymerase II promoter ^[9]
• Researchers have inferred, based on genetic interactions, that the gene product of Pik3r1
  • participates in the following biological processes:
    • cellular response to UV based on interactions with Nfatc3 ^[9]
    • negative regulation of apoptotic process based on interactions with Fasl, Nf1 ^[4]
    • negative regulation of cell-matrix adhesion based on interactions with Nf1 ^[12]
    • negative regulation of osteoclast differentiation based on interactions with Nf1 ^[12]
    • positive regulation of apoptotic process based on interactions with Tnf ^[9]
    • positive regulation of cell migration based on interactions with Nf1 ^[12]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Pik3r1:
  • participates in the following biological processes:
    • glucose metabolic process
    • growth hormone receptor signaling pathway
    • insulin receptor signaling pathway
    • insulin-like growth factor receptor signaling pathway
    • negative regulation of blood pressure
    • negative regulation of cell-cell adhesion
    • negative regulation of heart rate
    • negative regulation of muscle cell apoptotic process
    • negative regulation of proteolysis
    • negative regulation of smooth muscle cell proliferation
    • phosphatidylinositol 3-kinase cascade
    • positive regulation of cell migration
    • positive regulation of gene expression
    • positive regulation of myoblast differentiation
    • positive regulation of protein phosphorylation
    • regulation of phosphatidylinositol 3-kinase activity
    • response to cAMP
    • response to glucocorticoid stimulus
    • response to insulin stimulus
  • performs the following molecular functions:
    • 1-phosphatidylinositol-3-kinase activity
    • 1-phosphatidylinositol-3-kinase regulator activity
    • ATPase binding
    • calmodulin binding
    • ErbB-3 class receptor binding
    • estrogen receptor binding
    • insulin binding
    • insulin receptor binding
    • insulin receptor substrate binding
    • insulin-like growth factor receptor binding
    • neurotrophin TRKA receptor binding
    • phosphatidylinositol 3-kinase binding
    • phosphoprotein binding
    • platelet-derived growth factor receptor binding
    • protein C-terminus binding
    • protein domain specific binding
    • protein kinase binding
    • protein phosphatase binding
    • receptor binding
    • receptor tyrosine kinase binding
    • ubiquitin protein ligase binding
  • is located in the following cellular components:
    • membrane
    • neuron projection
    • nucleus
    • phosphatidylinositol 3-kinase complex
    • plasma membrane
    • protein complex

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Summary text based on GO annotations supported by structural data

• Pik3r1 encodes a protein or proteins that contain the following InterPro domains: PI3 kinase, P85 regulatory subunit, Rho GTPase activation protein, Rho GTPase-activating protein domain, SH2 domain, Src homology-3 domain, Variant SH3, indicating that the gene product:
  • participates in the following biological processes:
    • signal transduction
  • performs the following molecular functions:
    • phosphatidylinositol 3-kinase regulator activity
  • is located in the following cellular components:
    • intracellular

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Pik3r1 indicates that it:
  • participates in the following biological processes:
    • phosphorylation
  • performs the following molecular functions:
    • kinase activity

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References

1. Ahn E et al. (2006) LIME acts as a transmembrane adapter mediating BCR-dependent B-cell activation. Blood, 107:1521-7. (PubMed:16249387)
2. Baki L et al. (2004) PS1 activates PI3K thus inhibiting GSK-3 activity and tau overphosphorylation: effects of FAD mutations. EMBO J, 23:2586-96. (PubMed:15192701)
3. Furuya F et al. (2007) Nuclear receptor corepressor is a novel regulator of phosphatidylinositol 3-kinase signaling. Mol Cell Biol, 27:6116-26. (PubMed:17606624)
4. Hiatt K et al. (2004) Loss of the nf1 tumor suppressor gene decreases fas antigen expression in myeloid cells. Am J Pathol, 164:1471-9. (PubMed:15039234)
5. Holgado-Madruga M et al. (2003) Gab1 is an integrator of cell death versus cell survival signals in oxidative stress. Mol Cell Biol, 23:4471-84. (PubMed:12808090)
6. Luo J et al. (2005) The p85 regulatory subunit of phosphoinositide 3-kinase down-regulates IRS-1 signaling via the formation of a sequestration complex. J Cell Biol, 170:455-64. (PubMed:16043515)
7. Papin J et al. (2004) Bioinformatics and cellular signaling. Curr Opin Biotechnol, 15:78-81. (PubMed:15102471)
8. Riedel H et al. (2000) PSM, a mediator of PDGF-BB-, IGF-I-, and insulin-stimulated mitogenesis. Oncogene, 19:39-50. (PubMed:10644978)
9. Song L et al. (2007) p85alpha acts as a novel signal transducer for mediation of cellular apoptotic response to UV radiation. Mol Cell Biol, 27:2713-31. (PubMed:17242187)
10. Suzuki H et al. (2001) Protein-protein interaction panel using mouse full-length cDNAs. Genome Res, 11:1758-65. (PubMed:11591653)
11. Terauchi Y et al. (1999) Increased insulin sensitivity and hypoglycaemia in mice lacking the P85 alpha subunit of phosphoinositide 3- kinase. Nat Genet, 21:230-235. (PubMed:9988280)
12. Yang FC et al. (2006) Hyperactivation of p21 and PI3K cooperate to alter murine and human neurofibromatosis type 1-haploinsufficient osteoclast functions. J Clin Invest, 116:2880-91. (PubMed:17053831)
13. Yu WM et al. (2002) Role of the docking protein Gab2 in beta(1)-integrin signaling pathway-mediated hematopoietic cell adhesion and migration. Blood, 99:2351-9. (PubMed:11895767)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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