GO Annotations Graph

• Symbol: Pik3r1
• Name: phosphoinositide-3-kinase regulatory subunit 1
• ID: MGI:97583

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0016303	1-phosphatidylinositol-3-kinase activity	ISO	J:155856
Molecular Function	GO:0016303	1-phosphatidylinositol-3-kinase activity	TAS	J:52576
Molecular Function	GO:0046935	1-phosphatidylinositol-3-kinase regulator activity	ISO	J:155856
Molecular Function	GO:0046935	1-phosphatidylinositol-3-kinase regulator activity	IBA	J:265628
Molecular Function	GO:0046935	1-phosphatidylinositol-3-kinase regulator activity	IDA	J:23766
Molecular Function	GO:0046935	1-phosphatidylinositol-3-kinase regulator activity	IDA	J:36742
Molecular Function	GO:0046935	1-phosphatidylinositol-3-kinase regulator activity	IMP	J:125968
Molecular Function	GO:0046935	1-phosphatidylinositol-3-kinase regulator activity	ISO	J:327402
Molecular Function	GO:0051117	ATPase binding	ISO	J:155856
Molecular Function	GO:0005516	calmodulin binding	ISO	J:155856
Molecular Function	GO:0043125	ErbB-3 class receptor binding	ISO	J:164563
Molecular Function	GO:0043559	insulin binding	ISO	J:164563
Molecular Function	GO:0005158	insulin receptor binding	ISO	J:164563
Molecular Function	GO:0043560	insulin receptor substrate binding	ISO	J:155856
Molecular Function	GO:0043560	insulin receptor substrate binding	IPI	J:114734
Molecular Function	GO:0005159	insulin-like growth factor receptor binding	ISO	J:164563
Molecular Function	GO:0019209	kinase activator activity	IDA	J:23766
Molecular Function	GO:0019209	kinase activator activity	IDA	J:36742
Molecular Function	GO:0019209	kinase activator activity	IMP	J:125968
Molecular Function	GO:0019209	kinase activator activity	ISO	J:327402
Molecular Function	GO:0005168	neurotrophin TRKA receptor binding	ISO	J:164563
Molecular Function	GO:0030331	nuclear estrogen receptor binding	ISO	J:155856
Molecular Function	GO:0036312	phosphatidylinositol 3-kinase regulatory subunit binding	IPI	J:159304
Molecular Function	GO:0051219	phosphoprotein binding	ISO	J:155856
Molecular Function	GO:0001784	phosphotyrosine residue binding	ISO	J:164563
Molecular Function	GO:0005161	platelet-derived growth factor receptor binding	ISO	J:155856
Molecular Function	GO:0005515	protein binding	IPI	J:180006
Molecular Function	GO:0005515	protein binding	IPI	J:200509
Molecular Function	GO:0005515	protein binding	IPI	J:196250
Molecular Function	GO:0005515	protein binding	IPI	J:136236
Molecular Function	GO:0005515	protein binding	IPI	J:159304
Molecular Function	GO:0005515	protein binding	IPI	J:201303
Molecular Function	GO:0005515	protein binding	IPI	J:172913
Molecular Function	GO:0005515	protein binding	IPI	J:130473
Molecular Function	GO:0005515	protein binding	IPI	J:114108
Molecular Function	GO:0005515	protein binding	IPI	J:257322
Molecular Function	GO:0005515	protein binding	IPI	J:273694
Molecular Function	GO:0005515	protein binding	IPI	J:226873
Molecular Function	GO:0005515	protein binding	IPI	J:132675
Molecular Function	GO:0005515	protein binding	IPI	J:91529
Molecular Function	GO:0005515	protein binding	IPI	J:75835
Molecular Function	GO:0005515	protein binding	IPI	J:230033
Molecular Function	GO:0005515	protein binding	IPI	J:66479
Molecular Function	GO:0005515	protein binding	IPI	J:204720
Molecular Function	GO:0005515	protein binding	IPI	J:147628
Molecular Function	GO:0005515	protein binding	IPI	J:83953
Molecular Function	GO:0005515	protein binding	IPI	J:103507
Molecular Function	GO:0005515	protein binding	IPI	J:125047
Molecular Function	GO:0005515	protein binding	IPI	J:129312
Molecular Function	GO:0005515	protein binding	IPI	J:125047
Molecular Function	GO:0005515	protein binding	IPI	J:77039
Molecular Function	GO:0005515	protein binding	IPI	J:217307
Molecular Function	GO:0019904	protein domain specific binding	ISO	J:155856
Molecular Function	GO:0046982	protein heterodimerization activity	IPI	J:159304
Molecular Function	GO:0019901	protein kinase binding	ISO	J:155856
Molecular Function	GO:0019903	protein phosphatase binding	ISO	J:164563
Molecular Function	GO:0030971	receptor tyrosine kinase binding	ISO	J:155856
Molecular Function	GO:0005102	signaling receptor binding	ISO	J:155856
Molecular Function	GO:0031625	ubiquitin protein ligase binding	ISO	J:155856
Cellular Component	GO:0005911	cell-cell junction	IDA	J:205441
Cellular Component	GO:0005801	cis-Golgi network	IDA	J:217307
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IDA	J:114734
Cellular Component	GO:0005829	cytosol	IDA	J:114734
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-5218853
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9027268
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9031553
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9607226
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9680646
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9682158
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9682182
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-NUL-9031077
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-NUL-9603412
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-NUL-9616944
Cellular Component	GO:0016020	membrane	IDA	J:114734
Cellular Component	GO:0016020	membrane	ISO	J:155856
Cellular Component	GO:0043005	neuron projection	ISO	J:155856
Cellular Component	GO:0005634	nucleus	IDA	J:159304
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:1990578	perinuclear endoplasmic reticulum membrane	IDA	J:217307
Cellular Component	GO:0048471	perinuclear region of cytoplasm	IDA	J:292595
Cellular Component	GO:0005942	phosphatidylinositol 3-kinase complex	ISO	J:155856
Cellular Component	GO:0005942	phosphatidylinositol 3-kinase complex	IBA	J:265628
Cellular Component	GO:0005942	phosphatidylinositol 3-kinase complex	TAS	J:52576
Cellular Component	GO:0005943	phosphatidylinositol 3-kinase complex, class IA	ISO	J:164563
Cellular Component	GO:0005943	phosphatidylinositol 3-kinase complex, class IA	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	ISO	J:155856
Cellular Component	GO:0032991	protein-containing complex	ISO	J:155856
Cellular Component	GO:0032991	protein-containing complex	IDA	J:230033
Biological Process	GO:0030183	B cell differentiation	IMP	J:52576
Biological Process	GO:0032869	cellular response to insulin stimulus	IDA	J:159304
Biological Process	GO:0032869	cellular response to insulin stimulus	IDA	J:230033
Biological Process	GO:0034644	cellular response to UV	IGI	J:121372
Biological Process	GO:0034644	cellular response to UV	IMP	J:121372
Biological Process	GO:0008625	extrinsic apoptotic signaling pathway via death domain receptors	IMP	J:89131
Biological Process	GO:0008625	extrinsic apoptotic signaling pathway via death domain receptors	IGI	J:89131
Biological Process	GO:0006006	glucose metabolic process	ISO	J:155856
Biological Process	GO:0060396	growth hormone receptor signaling pathway	ISO	J:164563
Biological Process	GO:0008286	insulin receptor signaling pathway	IMP	J:159304
Biological Process	GO:0008286	insulin receptor signaling pathway	ISO	J:155856
Biological Process	GO:0008286	insulin receptor signaling pathway	IBA	J:265628
Biological Process	GO:0008286	insulin receptor signaling pathway	IDA	J:23766
Biological Process	GO:0008286	insulin receptor signaling pathway	IDA	J:36742
Biological Process	GO:0048009	insulin-like growth factor receptor signaling pathway	ISO	J:164563
Biological Process	GO:0048009	insulin-like growth factor receptor signaling pathway	ISO	J:155856
Biological Process	GO:0048009	insulin-like growth factor receptor signaling pathway	IMP	J:125968
Biological Process	GO:0048009	insulin-like growth factor receptor signaling pathway	IDA	J:307414
Biological Process	GO:0001678	intracellular glucose homeostasis	IDA	J:159304
Biological Process	GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage	IGI	J:121372
Biological Process	GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage	IMP	J:121372
Biological Process	GO:0097529	myeloid leukocyte migration	IGI	J:114609
Biological Process	GO:0043066	negative regulation of apoptotic process	ISO	J:164563
Biological Process	GO:0043066	negative regulation of apoptotic process	IDA	J:91529
Biological Process	GO:0045776	negative regulation of blood pressure	ISO	J:155856
Biological Process	GO:0007162	negative regulation of cell adhesion	IDA	J:217307
Biological Process	GO:0022408	negative regulation of cell-cell adhesion	ISO	J:155856
Biological Process	GO:0001953	negative regulation of cell-matrix adhesion	IGI	J:114609
Biological Process	GO:0010459	negative regulation of heart rate	ISO	J:155856
Biological Process	GO:0010656	negative regulation of muscle cell apoptotic process	ISO	J:155856
Biological Process	GO:0045671	negative regulation of osteoclast differentiation	IGI	J:114609
Biological Process	GO:0045861	negative regulation of proteolysis	ISO	J:155856
Biological Process	GO:0048662	negative regulation of smooth muscle cell proliferation	ISO	J:155856
Biological Process	GO:0051497	negative regulation of stress fiber assembly	IDA	J:292595
Biological Process	GO:0030316	osteoclast differentiation	IGI	J:114609
Biological Process	GO:0014065	phosphatidylinositol 3-kinase signaling	ISO	J:164563
Biological Process	GO:0046854	phosphatidylinositol phosphate biosynthetic process	IBA	J:265628
Biological Process	GO:0030335	positive regulation of cell migration	ISO	J:155856
Biological Process	GO:1900103	positive regulation of endoplasmic reticulum unfolded protein response	ISO	J:164563
Biological Process	GO:0051491	positive regulation of filopodium assembly	IDA	J:292595
Biological Process	GO:0120183	positive regulation of focal adhesion disassembly	IDA	J:292595
Biological Process	GO:0010628	positive regulation of gene expression	ISO	J:155856
Biological Process	GO:0010592	positive regulation of lamellipodium assembly	IDA	J:292595
Biological Process	GO:0002687	positive regulation of leukocyte migration	IGI	J:114609
Biological Process	GO:0045663	positive regulation of myoblast differentiation	ISO	J:155856
Biological Process	GO:0042307	positive regulation of protein import into nucleus	IMP	J:159304
Biological Process	GO:0042307	positive regulation of protein import into nucleus	ISO	J:164563
Biological Process	GO:0042307	positive regulation of protein import into nucleus	IMP	J:159304
Biological Process	GO:0001934	positive regulation of protein phosphorylation	ISO	J:155856
Biological Process	GO:0033120	positive regulation of RNA splicing	ISO	J:164563
Biological Process	GO:0051965	positive regulation of synapse assembly	ISO	J:155856
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:159304
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IMP	J:121372
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	IMP	J:121372
Biological Process	GO:0006606	protein import into nucleus	IMP	J:121372
Biological Process	GO:0006468	protein phosphorylation	IDA	J:91529
Biological Process	GO:0050821	protein stabilization	ISO	J:164563
Biological Process	GO:0015031	protein transport	IEA	J:60000
Biological Process	GO:0046626	regulation of insulin receptor signaling pathway	IGI	J:230033
Biological Process	GO:0043551	regulation of phosphatidylinositol 3-kinase activity	ISO	J:155856
Biological Process	GO:0043551	regulation of phosphatidylinositol 3-kinase activity	IBA	J:265628
Biological Process	GO:1903076	regulation of protein localization to plasma membrane	IDA	J:217307
Biological Process	GO:0051492	regulation of stress fiber assembly	IMP	J:217307
Biological Process	GO:0051591	response to cAMP	ISO	J:155856
Biological Process	GO:0034976	response to endoplasmic reticulum stress	IDA	J:159304
Biological Process	GO:0034976	response to endoplasmic reticulum stress	ISO	J:164563
Biological Process	GO:0051384	response to glucocorticoid	ISO	J:155856
Biological Process	GO:0032868	response to insulin	ISO	J:155856
Biological Process	GO:0007165	signal transduction	IEA	J:72247
Biological Process	GO:0006366	transcription by RNA polymerase II	IMP	J:121372
Biological Process	GO:0032640	tumor necrosis factor production	IMP	J:121372