Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Pgk1. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a glycolytic enzyme that catalyzes the conversion of 1,3-diphosphoglycerate to 3-phosphoglycerate. The encoded protein may also act as a cofactor for polymerase alpha. This gene lies on the X-chromosome, while a related pseudogene also has been found on the X-chromosome and another on chromosome 19. [provided by RefSeq, Oct 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Pgk1
  • participates in the following biological processes:
    • phosphorylation ^{[1, 2, 3]}
  • performs the following molecular functions:
    • phosphoglycerate kinase activity ^{[1, 2, 3]}

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Pgk1:
  • participates in the following biological processes:
    • carbohydrate metabolic process
    • gluconeogenesis
    • glycolysis
  • performs the following molecular functions:
    • ADP binding
    • ATP binding
    • phosphoglycerate kinase activity
  • is located in the following cellular components:
    • cytosol

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References

1. Chapman VM et al. (1983) Electrophoretic variation for X chromosome-linked hypoxanthine phosphoribosyl transferase (HPRT) in wild-derived mice. Genetics, 103:785-95. (PubMed:6852525)
2. Chapman VM et al. (1976) Somatic cell genetic evidence for X-chromosome linkage of three enzymes in the mouse. Nature, 259:665-7. (PubMed:943046)
3. Nielsen JT et al. (1977) Electrophoretic Variation for X-Chromosome-Linked Phosphoglycerate Kinase (Pgk-1) in the Mouse. Genetics, 87:319-325. (PubMed:17248765)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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