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Gene Ontology Classifications
pre B cell leukemia homeobox 1

Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Pbx1. (This text reflects annotations as of Tuesday, May 26, 2015.)
Summary from NCBI RefSeq

This gene encodes a homeobox protein that belongs to the three-amino-acid loop extension/Pre-B cell leukemia transcription factor (TALE/PBX) family of proteins. The encoded protein is involved in several biological processes during embryogenesis including steroidogenesis, sexual development and the maintenance of hematopoietic stem cells. This protein functions in the development of several organ systems and plays a role in skeletal patterning and programming. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by experimental evidence in other organisms
Summary text based on GO annotations supported by structural data
Summary text for additional MGI annotations
  1. Bailey JS et al. (2004) Activin regulation of the follicle-stimulating hormone beta-subunit gene involves Smads and the TALE homeodomain proteins Pbx1 and Prep1. Mol Endocrinol, 18:1158-70. (PubMed:14764653)
  2. Brendolan A et al. (2005) A Pbx1-dependent genetic and transcriptional network regulates spleen ontogeny. Development, 132:3113-26. (PubMed:15944191)
  3. Capellini TD et al. (2006) Pbx1/Pbx2 requirement for distal limb patterning is mediated by the hierarchical control of Hox gene spatial distribution and Shh expression. Development, 133:2263-73. (PubMed:16672333)
  4. Chang CP et al. (1997) Meis proteins are major in vivo DNA binding partners for wild-type but not chimeric Pbx proteins. Mol Cell Biol, 17:5679-87. (PubMed:9315626)
  5. DiMartino JF et al. (2001) The Hox cofactor and proto-oncogene Pbx1 is required for maintenance of definitive hematopoiesis in the fetal liver. Blood, 98:618-26. (PubMed:11468159)
  6. Ferretti E et al. (2006) Hypomorphic mutation of the TALE gene Prep1 (pKnox1) causes a major reduction of Pbx and Meis proteins and a pleiotropic embryonic phenotype. Mol Cell Biol, 26:5650-62. (PubMed:16847320)
  7. Ferretti E et al. (1999) The PBX-regulating protein PREP1 is present in different PBX-complexed forms in mouse. Mech Dev, 83:53-64. (PubMed:10381567)
  8. Huang H et al. (2003) Nonmuscle myosin promotes cytoplasmic localization of PBX. Mol Cell Biol, 23:3636-45. (PubMed:12724421)
  9. Kim SK et al. (2002) Pbx1 inactivation disrupts pancreas development and in Ipf1-deficient mice promotes diabetes mellitus. Nat Genet, 30:430-5. (PubMed:11912494)
  10. Knoepfler PS et al. (1997) Meis1 and pKnox1 bind DNA cooperatively with Pbx1 utilizing an interaction surface disrupted in oncoprotein E2a-Pbx1. Proc Natl Acad Sci U S A, 94:14553-8. (PubMed:9405651)
  11. Koss M et al. (2012) Congenital Asplenia in Mice and Humans with Mutations in a Pbx/Nkx2-5/p15 Module. Dev Cell, 22:913-26. (PubMed:22560297)
  12. Kutejova E et al. (2005) Hoxa2 downregulates Six2 in the neural crest-derived mesenchyme. Development, 132:469-78. (PubMed:15634706)
  13. Manley NR et al. (2004) Abnormalities of caudal pharyngeal pouch development in Pbx1 knockout mice mimic loss of Hox3 paralogs. Dev Biol, 276:301-12. (PubMed:15581866)
  14. Mojsin M et al. (2010) PBX1 and MEIS1 up-regulate SOX3 gene expression by direct interaction with a consensus binding site within the basal promoter region. Biochem J, 425:107-16. (PubMed:19799567)
  15. Saleh M et al. (2000) A conformational change in PBX1A is necessary for its nuclear localization Exp Cell Res, 260:105-15. (PubMed:11010815)
  16. Schnabel CA et al. (2003) Pbx1 regulates nephrogenesis and ureteric branching in the developing kidney. Dev Biol, 254:262-76. (PubMed:12591246)
  17. Schnabel CA et al. (2003) Pbx1 is essential for adrenal development and urogenital differentiation. Genesis, 37:123-30. (PubMed:14595835)
  18. Selleri L et al. (2001) Requirement for Pbx1 in skeletal patterning and programming chondrocyte proliferation and differentiation. Development, 128:3543-57. (PubMed:11566859)
  19. Toresson H et al. (2000) Expression of meis and pbx genes and their protein products in the developing telencephalon: implications for regional differentiation Mech Dev, 94:183-7. (PubMed:10842069)
  20. Villaescusa JC et al. (2004) Expression of Hox cofactor genes during mouse ovarian follicular development and oocyte maturation. Gene, 330:1-7. (PubMed:15087118)
  21. Wassef MA et al. (2008) Rostral hindbrain patterning involves the direct activation of a Krox20 transcriptional enhancer by Hox/Pbx and Meis factors. Development, 135:3369-78. (PubMed:18787068)
  22. Yang X et al. (2008) Altered neuronal lineages in the facial ganglia of Hoxa2 mutant mice. Dev Biol, 314:171-88. (PubMed:18164701)
  23. Zhang X et al. (2006) Pax6 is regulated by Meis and Pbx homeoproteins during pancreatic development. Dev Biol, 300:748-57. (PubMed:17049510)

Go Annotations in Tabular Form (Text View) (GO Graph)

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Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IAS Inferred from ancestral sequence
  IBA Inferred from biological aspect of ancestor
  IBD Inferred from biological aspect of descendant
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IKR Inferred from key residues
  IMP Inferred from mutant phenotype
  IMR Inferred from missing residues
  IPI Inferred from physical interaction
  IRD Inferred from rapid divergence
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


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