Automated description from the Alliance of Genome Resources (Release 4.0)
Enables several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; SMAD binding activity; and enzyme binding activity. Involved in several processes, including pancreatic A cell development; regulation of transcription by RNA polymerase II; and ventral spinal cord development. Acts upstream of or within several processes, including animal organ development; negative regulation of cell population proliferation; and nervous system development. Located in chromatin and nucleus. Is expressed in several structures, including alimentary system; central nervous system; embryo ectoderm; eye; and nose. Used to study Peters anomaly; aniridia; cataract; and juvenile glaucoma. Human ortholog(s) of this gene implicated in bilateral optic nerve hypoplasia; eye disease (multiple); glucose intolerance; and paranoid schizophrenia. Orthologous to human PAX6 (paired box 6).