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Gene Ontology Classifications
Symbol
Name
ID
Otx2
orthodenticle homolog 2
MGI:97451

Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Otx2. (This text reflects annotations as of Thursday, July 24, 2014.)
Summary from NCBI RefSeq


This gene encodes a protein that belongs to the homeobox family of transcription factors. The encoded protein plays a role in the development and patterning of the head. This protein regulates development of the choroid plexuses in the brain affecting composition of cerebrospinal fluid in the developing brain and is thought to function in the development of sense organs in the embryo. In humans, mutations in this gene are associated with pituitary hormone deficiency. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Nov 2013]
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by experimental evidence in other organisms
Summary text based on GO annotations supported by structural data
Summary text for additional MGI annotations
References
  1. Baas D et al. (2000) The subcellular localization of OTX2 is cell-type specific and developmentally regulated in the mouse retina Brain Res Mol Brain Res, 78:26-37. (PubMed:10891582)
  2. Biben C et al. (1998) Murine cerberus homologue mCer-1: a candidate anterior patterning molecule. Dev Biol, 194:135-51. (PubMed:9501024)
  3. Inoue T et al. (2006) Cloning and characterization of mr-s, a novel SAM domain protein, predominantly expressed in retinal photoreceptor cells. BMC Dev Biol, 6:15. (PubMed:16539743)
  4. Iwafuchi-Doi M et al. (2012) Transcriptional regulatory networks in epiblast cells and during anterior neural plate development as modeled in epiblast stem cells. Development, 139:3926-37. (PubMed:22992956)
  5. Kimura C et al. (2001) Complementary functions of Otx2 and Cripto in initial patterning of mouse epiblast. Dev Biol, 235:12-32. (PubMed:11412024)
  6. Kimura J et al. (2005) Emx2 and Pax6 function in cooperation with Otx2 and Otx1 to develop caudal forebrain primordium that includes future archipallium. J Neurosci, 25:5097-108. (PubMed:15917450)
  7. Kimura K et al. (2005) Functional analysis of transcriptional repressor Otx3/Dmbx1. FEBS Lett, 579:2926-32. (PubMed:15890343)
  8. Kinder SJ et al. (2001) Defects of the body plan of mutant embryos lacking Lim1, Otx2 or Hnf3beta activity. Int J Dev Biol, 45:347-55. (PubMed:11291865)
  9. Konno D et al. (2012) The mammalian DM domain transcription factor Dmrta2 is required for early embryonic development of the cerebral cortex. PLoS One, 7:e46577. (PubMed:23056351)
  10. Kurokawa D et al. (2004) Regulation of Otx2 expression and its functions in mouse forebrain and midbrain. Development, 131:3319-31. (PubMed:15201224)
  11. Kurokawa D et al. (2004) Regulation of Otx2 expression and its functions in mouse epiblast and anterior neuroectoderm. Development, 131:3307-17. (PubMed:15201223)
  12. Martinez-Barbera JP et al. (2001) Regionalisation of anterior neuroectoderm and its competence in responding to forebrain and midbrain inducing activities depend on mutual antagonism between OTX2 and GBX2. Development, 128:4789-800. (PubMed:11731459)
  13. Morsli H et al. (1999) Otx1 and Otx2 activities are required for the normal development of the mouse inner ear. Development, 126:2335-43. (PubMed:10225993)
  14. Nishida A et al. (2003) Otx2 homeobox gene controls retinal photoreceptor cell fate and pineal gland development. Nat Neurosci, 6:1255-63. (PubMed:14625556)
  15. Nishiyama A et al. (2009) Uncovering early response of gene regulatory networks in ESCs by systematic induction of transcription factors. Cell Stem Cell, 5:420-33. (PubMed:19796622)
  16. Prakash N et al. (2009) Nkx6-1 controls the identity and fate of red nucleus and oculomotor neurons in the mouse midbrain. Development, 136:2545-55. (PubMed:19592574)
  17. Prakash N et al. (2006) A Wnt1-regulated genetic network controls the identity and fate of midbrain-dopaminergic progenitors in vivo. Development, 133:89-98. (PubMed:16339193)
  18. Puelles E et al. (2004) Otx2 regulates the extent, identity and fate of neuronal progenitor domains in the ventral midbrain. Development, 131:2037-48. (PubMed:15105370)
  19. Puelles E et al. (2003) Otx dose-dependent integrated control of antero-posterior and dorso-ventral patterning of midbrain. Nat Neurosci, 6:453-60. (PubMed:12652306)
  20. Sakurai Y et al. (2010) Otx2 and Otx1 protect diencephalon and mesencephalon from caudalization into metencephalon during early brain regionalization. Dev Biol, 347:392-403. (PubMed:20816794)
  21. Vernay B et al. (2005) Otx2 regulates subtype specification and neurogenesis in the midbrain. J Neurosci, 25:4856-67. (PubMed:15888661)



Go Annotations in Tabular Form (Text View) (GO Graph)

 
 


Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IMP Inferred from mutant phenotype
  IPI Inferred from physical interaction
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory