Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Npr2. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes natriuretic peptide receptor B, one of two integral membrane receptors for natriuretic peptides. Both NPR1 and NPR2 contain five functional domains: an extracellular ligand-binding domain, a single membrane-spanning region, and intracellularly a protein kinase homology domain, a helical hinge region involved in oligomerization, and a carboxyl-terminal guanylyl cyclase catalytic domain. The protein is the primary receptor for C-type natriuretic peptide (CNP), which upon ligand binding exhibits greatly increased guanylyl cyclase activity. Mutations in this gene are the cause of acromesomelic dysplasia Maroteaux type. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Npr2
  • participates in the following biological processes:
    • cGMP biosynthetic process ^[2]
    • signal transduction ^[2]
  • performs the following molecular functions:
    • guanylate cyclase activity ^[2]
    • natriuretic peptide receptor activity ^[2]
• Researchers have inferred, based on physical interactions, that the gene product of Npr2
  • performs the following molecular functions:
    • identical protein binding ^[2]
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Npr2
  • participates in the following biological processes:
    • bone development ^[1]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Npr2:
  • participates in the following biological processes:
    • cGMP biosynthetic process
    • receptor guanylyl cyclase signaling pathway
  • performs the following molecular functions:
    • ATP binding
    • GTP binding
    • guanylate cyclase activity
    • hormone binding
    • natriuretic peptide receptor activity
    • peptide hormone binding
  • is located in the following cellular components:
    • plasma membrane

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Summary text based on GO annotations supported by structural data

• Npr2 encodes a protein or proteins that contain the following InterPro domains: Adenylyl cyclase class-3/4/guanylyl cyclase, Adenylyl cyclase class-3/4/guanylyl cyclase, conserved site, Extracellular ligand-binding receptor, Haem NO binding associated, Natriuretic peptide receptor, Protein kinase, catalytic domain, Protein kinase-like domain, Serine-threonine/tyrosine-protein kinase catalytic domain, indicating that the gene product:
  • participates in the following biological processes:
    • cyclic nucleotide biosynthetic process
    • intracellular signal transduction
    • protein phosphorylation
  • performs the following molecular functions:
    • phosphorus-oxygen lyase activity
    • protein kinase activity
    • transferase activity, transferring phosphorus-containing groups
  • is located in the following cellular components:
    • integral to membrane

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Npr2 indicates that it:
  • participates in the following biological processes:
    • ossification
  • performs the following molecular functions:
    • lyase activity
    • nucleotide binding
  • is located in the following cellular components:
    • integral to membrane
    • membrane

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References

1. Johnson DR. (1978) The growth of femur and tibia in three genetically distinct chondrodystrophic mutants of the house mouse. J Anat, 125:267-75. (PubMed:624676)
2. Tamura N et al. (2003) Regulation of the guanylyl cyclase-B receptor by alternative splicing. J Biol Chem, 278:48880-9. (PubMed:14514678)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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