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Gene Ontology Classifications
notch 1

Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Notch1. (This text reflects annotations as of Tuesday, May 26, 2015.)
Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play multiple roles during development. [provided by RefSeq, Jul 2008]
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by experimental evidence in other organisms
Summary text based on GO annotations supported by structural data
Summary text for additional MGI annotations
  1. Amsen D et al. (2007) Direct regulation of gata3 expression determines the T helper differentiation potential of notch. Immunity, 27:89-99. (PubMed:17658279)
  2. Bansal K et al. (2011) Intracellular pathogen sensor NOD2 programs macrophages to trigger Notch1 activation. J Biol Chem, 286:5823-35. (PubMed:21156799)
  3. Bessho Y et al. (2003) Periodic repression by the bHLH factor Hes7 is an essential mechanism for the somite segmentation clock. Genes Dev, 17:1451-6. (PubMed:12783854)
  4. Blanpain C et al. (2006) Canonical notch signaling functions as a commitment switch in the epidermal lineage. Genes Dev, 20:3022-35. (PubMed:17079689)
  5. Casey LM et al. (2006) Jag2-Notch1 signaling regulates oral epithelial differentiation and palate development. Dev Dyn, 235:1830-1844. (PubMed:16607638)
  6. Coleman ML et al. (2007) Asparaginyl hydroxylation of the Notch ankyrin repeat domain by factor inhibiting hypoxia-inducible factor. J Biol Chem, 282:24027-38. (PubMed:17573339)
  7. Conlon RA et al. (1995) Notch1 is required for the coordinate segmentation of somites. Development, 121:1533-45. (PubMed:7789282)
  8. de la Pompa JL et al. (1997) Conservation of the Notch signalling pathway in mammalian neurogenesis. Development, 124:1139-48. (PubMed:9102301)
  9. De Strooper B et al. (1999) A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain [see comments] Nature, 398:518-22. (PubMed:10206645)
  10. Del Monte G et al. (2007) Monitoring Notch1 activity in development: Evidence for a feedback regulatory loop. Dev Dyn, 236:2594-614. (PubMed:17685488)
  11. del Monte G et al. (2011) Differential Notch signaling in the epicardium is required for cardiac inflow development and coronary vessel morphogenesis. Circ Res, 108:824-36. (PubMed:21311046)
  12. Doetzlhofer A et al. (2009) Hey2 regulation by FGF provides a Notch-independent mechanism for maintaining pillar cell fate in the organ of Corti. Dev Cell, 16:58-69. (PubMed:19154718)
  13. Eiraku M et al. (2005) DNER acts as a neuron-specific Notch ligand during Bergmann glial development. Nat Neurosci, 8:873-80. (PubMed:15965470)
  14. Fang TC et al. (2007) Notch directly regulates Gata3 expression during T helper 2 cell differentiation. Immunity, 27:100-10. (PubMed:17658278)
  15. Fischer A et al. (2007) Combined loss of Hey1 and HeyL causes congenital heart defects because of impaired epithelial to mesenchymal transition. Circ Res, 100:856-63. (PubMed:17303760)
  16. Fischer A et al. (2004) The Notch target genes Hey1 and Hey2 are required for embryonic vascular development. Genes Dev, 18:901-11. (PubMed:15107403)
  17. Francis JC et al. (2005) Notch1 signals through Jagged2 to regulate apoptosis in the apical ectodermal ridge of the developing limb bud. Dev Dyn, 234:1006-15. (PubMed:16245338)
  18. Fre S et al. (2009) Notch and Wnt signals cooperatively control cell proliferation and tumorigenesis in the intestine. Proc Natl Acad Sci U S A, 106:6309-14. (PubMed:19251639)
  19. Garg V et al. (2005) Mutations in NOTCH1 cause aortic valve disease. Nature, 437:270-4. (PubMed:16025100)
  20. Genoud S et al. (2002) Notch1 control of oligodendrocyte differentiation in the spinal cord. J Cell Biol, 158:709-18. (PubMed:12186854)
  21. Grego-Bessa J et al. (2007) Notch signaling is essential for ventricular chamber development. Dev Cell, 12:415-29. (PubMed:17336907)
  22. Grishina IB et al. (2005) BMP7 inhibits branching morphogenesis in the prostate gland and interferes with Notch signaling. Dev Biol, 288:334-47. (PubMed:16324690)
  23. Huang EJ et al. (2005) Targeted deletion of numb and numblike in sensory neurons reveals their essential functions in axon arborization. Genes Dev, 19:138-51. (PubMed:15598981)
  24. Jadhav AP et al. (2006) Notch 1 inhibits photoreceptor production in the developing mammalian retina. Development, 133:913-23. (PubMed:16452096)
  25. James AC et al. (2014) Notch4 reveals a novel mechanism regulating Notch signal transduction. Biochim Biophys Acta, 1843:1272-84. (PubMed:24667410)
  26. Jo HS et al. (2012) Pten coordinates retinal neurogenesis by regulating Notch signalling. EMBO J, 31:817-28. (PubMed:22258620)
  27. Kamakura S et al. (2004) Hes binding to STAT3 mediates crosstalk between Notch and JAK-STAT signalling. Nat Cell Biol, 6:547-54. (PubMed:15156153)
  28. Kawamata S et al. (2002) Overexpression of the Notch target genes Hes in vivo induces lymphoid and myeloid alterations. Oncogene, 21:3855-63. (PubMed:12032823)
  29. Kong Y et al. (2004) Functional diversity of notch family genes in fetal lung development. Am J Physiol Lung Cell Mol Physiol, 286:L1075-83. (PubMed:15064243)
  30. Kratsios P et al. (2010) Distinct roles for cell-autonomous Notch signaling in cardiomyocytes of the embryonic and adult heart. Circ Res, 106:559-72. (PubMed:20007915)
  31. Krebs LT et al. (2003) Notch signaling regulates left-right asymmetry determination by inducing Nodal expression. Genes Dev, 17:1207-12. (PubMed:12730124)
  32. Krolewski RC et al. (2012) Ascl1 (Mash1) knockout perturbs differentiation of nonneuronal cells in olfactory epithelium. PLoS One, 7:e51737. (PubMed:23284756)
  33. Kwon C et al. (2009) A regulatory pathway involving Notch1/beta-catenin/Isl1 determines cardiac progenitor cell fate. Nat Cell Biol, 11:951-7. (PubMed:19620969)
  34. Li W et al. (2015) Notch inhibition induces mitotically generated hair cells in mammalian cochleae via activating the Wnt pathway. Proc Natl Acad Sci U S A, 112:166-71. (PubMed:25535395)
  35. Limbourg FP et al. (2005) Essential role of endothelial Notch1 in angiogenesis. Circulation, 111:1826-32. (PubMed:15809373)
  36. Luna-Zurita L et al. (2010) Integration of a Notch-dependent mesenchymal gene program and Bmp2-driven cell invasiveness regulates murine cardiac valve formation. J Clin Invest, 120:3493-507. (PubMed:20890042)
  37. Luo B et al. (1997) Isolation and functional analysis of a cDNA for human Jagged2, a gene encoding a ligand for the Notch1 receptor. Mol Cell Biol, 17:6057-67. (PubMed:9315665)
  38. Mason HA et al. (2005) Notch signaling coordinates the patterning of striatal compartments. Development, 132:4247-58. (PubMed:16120638)
  39. Masserdotti G et al. (2010) ZFP423 coordinates Notch and bone morphogenetic protein signaling, selectively up-regulating Hes5 gene expression. J Biol Chem, 285:30814-24. (PubMed:20547764)
  40. Minoguchi S et al. (1997) RBP-L, a transcription factor related to RBP-Jkappa. Mol Cell Biol, 17:2679-87. (PubMed:9111338)
  41. Morimoto M et al. (2005) The Mesp2 transcription factor establishes segmental borders by suppressing Notch activity. Nature, 435:354-9. (PubMed:15902259)
  42. Murtaugh LC et al. (2003) Notch signaling controls multiple steps of pancreatic differentiation. Proc Natl Acad Sci U S A, 100:14920-5. (PubMed:14657333)
  43. Nguyen BC et al. (2006) Cross-regulation between Notch and p63 in keratinocyte commitment to differentiation. Genes Dev, 20:1028-42. (PubMed:16618808)
  44. Nigam V et al. (2009) Notch1 represses osteogenic pathways in aortic valve cells. J Mol Cell Cardiol, 47:828-34. (PubMed:19695258)
  45. Nus M et al. (2011) Diet-induced aortic valve disease in mice haploinsufficient for the Notch pathway effector RBPJK/CSL. Arterioscler Thromb Vasc Biol, 31:1580-8. (PubMed:21493891)
  46. Ohtsuka T et al. (1999) Hes1 and Hes5 as notch effectors in mammalian neuronal differentiation. EMBO J, 18:2196-207. (PubMed:10205173)
  47. Okuyama R et al. (2004) High commitment of embryonic keratinocytes to terminal differentiation through a Notch1-caspase 3 regulatory mechanism. Dev Cell, 6:551-62. (PubMed:15068794)
  48. Pan Y et al. (2004) gamma-secretase functions through Notch signaling to maintain skin appendages but is not required for their patterning or initial morphogenesis. Dev Cell, 7:731-43. (PubMed:15525534)
  49. Pan Y et al. (2005) Notch1 and 2 cooperate in limb ectoderm to receive an early Jagged2 signal regulating interdigital apoptosis. Dev Biol, 286:472-82. (PubMed:16169548)
  50. Rajan S et al. (2011) Analysis of early C2C12 myogenesis identifies stably and differentially expressed transcriptional regulators whose knock-down inhibits myoblast differentiation. Physiol Genomics, null:null. (PubMed:22147266)
  51. Rentschler S et al. (2011) Notch signaling regulates murine atrioventricular conduction and the formation of accessory pathways. J Clin Invest, 121:525-33. (PubMed:21266778)
  52. Reya T et al. (2003) A role for Wnt signalling in self-renewal of haematopoietic stem cells. Nature, 423:409-14. (PubMed:12717450)
  53. Robert-Moreno A et al. (2005) RBPj{kappa}-dependent Notch function regulates Gata2 and is essential for the formation of intra-embryonic hematopoietic cells. Development, 132:1117-26. (PubMed:15689374)
  54. Rock R et al. (2005) Fjx1: a notch-inducible secreted ligand with specific binding sites in developing mouse embryos and adult brain. Dev Dyn, 234:602-12. (PubMed:16145673)
  55. Sanchez-Solana B et al. (2011) The EGF-like proteins DLK1 and DLK2 function as inhibitory non-canonical ligands of NOTCH1 receptor that modulate each other's activities. Biochim Biophys Acta, 1813:1153-64. (PubMed:21419176)
  56. Shimizu K et al. (1999) Mouse jagged1 physically interacts with notch2 and other notch receptors. Assessment by quantitative methods. J Biol Chem, 274:32961-9. (PubMed:10551863)
  57. Shimizu K et al. (2000) Binding of Delta1, Jagged1, and Jagged2 to Notch2 rapidly induces cleavage, nuclear translocation, and hyperphosphorylation of Notch2. Mol Cell Biol, 20:6913-22. (PubMed:10958687)
  58. Stanger BZ et al. (2005) Direct regulation of intestinal fate by Notch. Proc Natl Acad Sci U S A, 102:12443-8. (PubMed:16107537)
  59. Tamura K et al. (1995) Physical interaction between a novel domain of the receptor Notch and the transcription factor RBP-J kappa/Su(H). Curr Biol, 5:1416-23. (PubMed:8749394)
  60. Tanimizu N et al. (2004) Notch signaling controls hepatoblast differentiation by altering the expression of liver-enriched transcription factors. J Cell Sci, 117:3165-74. (PubMed:15226394)
  61. Tiberi L et al. (2012) BCL6 controls neurogenesis through Sirt1-dependent epigenetic repression of selective Notch targets. Nat Neurosci, 15:1627-35. (PubMed:23160044)
  62. Timmerman LA et al. (2004) Notch promotes epithelial-mesenchymal transition during cardiac development and oncogenic transformation. Genes Dev, 18:99-115. (PubMed:14701881)
  63. Vauclair S et al. (2005) Notch1 is essential for postnatal hair follicle development and homeostasis. Dev Biol, 284:184-93. (PubMed:15978571)
  64. Wacker SA et al. (2011) RITA, a novel modulator of Notch signalling, acts via nuclear export of RBP-J. EMBO J, 30:43-56. (PubMed:21102556)
  65. Wang XD et al. (2006) Notch signaling is required for normal prostatic epithelial cell proliferation and differentiation. Dev Biol, 290:66-80. (PubMed:16360140)
  66. Webb JD et al. (2009) MYPT1, the targeting subunit of smooth-muscle myosin phosphatase, is a substrate for the asparaginyl hydroxylase factor inhibiting hypoxia-inducible factor (FIH). Biochem J, 420:327-33. (PubMed:19245366)
  67. Wu Y et al. (2003) Hes1 but not Hes5 regulates an astrocyte versus oligodendrocyte fate choice in glial restricted precursors. Dev Dyn, 226:675-89. (PubMed:12666205)
  68. Yang LT et al. (2005) Fringe glycosyltransferases differentially modulate Notch1 proteolysis induced by Delta1 and Jagged1. Mol Biol Cell, 16:927-42. (PubMed:15574878)
  69. Yang X et al. (2004) Notch activation induces apoptosis in neural progenitor cells through a p53-dependent pathway. Dev Biol, 269:81-94. (PubMed:15081359)
  70. Yoon K et al. (2004) Fibroblast growth factor receptor signaling promotes radial glial identity and interacts with Notch1 signaling in telencephalic progenitors. J Neurosci, 24:9497-506. (PubMed:15509736)
  71. Yun TJ et al. (2003) Notch-regulated ankyrin-repeat protein inhibits notch1 signaling: multiple notch1 signaling pathways involved in T cell development. J Immunol, 170:5834-41. (PubMed:12794108)
  72. Zhang N et al. (2002) Segmentation defects of Notch pathway mutants and absence of a synergistic phenotype in lunatic fringe/radical fringe double mutant mice. Genesis, 33:21-8. (PubMed:12001066)
  73. Zheng X et al. (2008) Interaction with factor inhibiting HIF-1 defines an additional mode of cross-coupling between the Notch and hypoxia signaling pathways. Proc Natl Acad Sci U S A, 105:3368-73. (PubMed:18299578)

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Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IAS Inferred from ancestral sequence
  IBA Inferred from biological aspect of ancestor
  IBD Inferred from biological aspect of descendant
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IKR Inferred from key residues
  IMP Inferred from mutant phenotype
  IMR Inferred from missing residues
  IPI Inferred from physical interaction
  IRD Inferred from rapid divergence
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


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