Automated description from the Alliance of Genome Resources (Release 3.1.1)
Exhibits several functions, including DNA binding activity; DNA-binding transcription activator activity, RNA polymerase II-specific; and Notch binding activity. Involved in several processes, including animal organ development; circulatory system development; and negative regulation of cell differentiation. Localizes to several cellular components, including adherens junction; apical plasma membrane; and cell surface. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; heart; and sensory organ. Human ortholog(s) of this gene implicated in Adams-Oliver syndrome; adult T-cell leukemia; and aortic valve disease 1. Orthologous to human NOTCH1 (notch receptor 1).