Automated description from the Alliance of Genome Resources
Exhibits several functions, including DNA binding activity; DNA-binding transcription activator activity, RNA polymerase II-specific; and enzyme binding activity. Involved in several processes, including animal organ development; circulatory system development; and negative regulation of cell differentiation. Localizes to several cellular components, including the adherens junction; apical plasma membrane; and cytoplasm. Human ortholog(s) of this gene implicated in Adams-Oliver syndrome; adult T-cell leukemia; and aortic valve disease 1. Orthologous to human NOTCH1 (notch receptor 1).