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Gene Ontology Classifications
neural precursor cell expressed, developmentally down-regulated 4

Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Nedd4. (This text reflects annotations as of Tuesday, May 26, 2015.) MGI curation of this mouse gene is considered complete, including annotations derived from the biomedical literature as of July 25, 2012. If you know of any additional information regarding this mouse gene please let us know. Please supply mouse gene symbol and a PubMed ID.
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by experimental evidence in other organisms
Summary text for additional MGI annotations
  1. Aitken JF et al. (2010) Tetracycline treatment retards the onset and slows the progression of diabetes in human amylin/islet amyloid polypeptide transgenic mice. Diabetes, 59:161-71. (PubMed:19794060)
  2. Fouladkou F et al. (2010) The ubiquitin ligase Nedd4-1 is required for heart development and is a suppressor of thrombospondin-1. J Biol Chem, 285:6770-80. (PubMed:20026598)
  3. Gavva NR et al. (1997) Interaction of WW domains with hematopoietic transcription factor p45/NF-E2 and RNA polymerase II. J Biol Chem, 272:24105-8. (PubMed:9305852)
  4. Harvey KF et al. (2002) N4WBP5, a potential target for ubiquitination by the Nedd4 family of proteins, is a novel Golgi-associated protein. J Biol Chem, 277:9307-17. (PubMed:11748237)
  5. Harvey KF et al. (1999) All three WW domains of murine Nedd4 are involved in the regulation of epithelial sodium channels by intracellular Na+. J Biol Chem, 274:12525-30. (PubMed:10212229)
  6. Hatakeyama S et al. (1997) Subcellular localization and ubiquitin-conjugating enzyme (E2) interactions of mammalian HECT family ubiquitin protein ligases. J Biol Chem, 272:15085-92. (PubMed:9182527)
  7. Heissmeyer V et al. (2004) Calcineurin imposes T cell unresponsiveness through targeted proteolysis of signaling proteins. Nat Immunol, 5:255-65. (PubMed:14973438)
  8. Jolliffe CN et al. (2000) Identification of multiple proteins expressed in murine embryos as binding partners for the WW domains of the ubiquitin-protein ligase nedd4 Biochem J, 351 Pt 3:557-65. (PubMed:11042109)
  9. Kawabe H et al. (2010) Regulation of Rap2A by the ubiquitin ligase Nedd4-1 controls neurite development. Neuron, 65:358-72. (PubMed:20159449)
  10. Liu Y et al. (2009) Abnormal development of the neuromuscular junction in Nedd4-deficient mice. Dev Biol, 330:153-66. (PubMed:19345204)
  11. Lu PJ et al. (1999) Function of WW domains as phosphoserine- or phosphothreonine-binding modules. Science, 283:1325-8. (PubMed:10037602)
  12. Morrione A et al. (1999) mGrb10 interacts with Nedd4. J Biol Chem, 274:24094-9. (PubMed:10446181)
  13. Murdaca J et al. (2004) Grb10 prevents Nedd4-mediated vascular endothelial growth factor receptor-2 degradation. J Biol Chem, 279:26754-61. (PubMed:15060076)
  14. Murillas R et al. (2002) Identification of developmentally expressed proteins that functionally interact with Nedd4 ubiquitin ligase. J Biol Chem, 277:2897-907. (PubMed:11717310)
  15. Sanchez-Perez A et al. (2007) GRK2 interacts with and phosphorylates Nedd4 and Nedd4-2. Biochem Biophys Res Commun, 359:611-5. (PubMed:17544362)
  16. Van Campenhout CA et al. (2011) Dlg3 trafficking and apical tight junction formation is regulated by nedd4 and nedd4-2 e3 ubiquitin ligases. Dev Cell, 21:479-91. (PubMed:21920314)
  17. Yang B et al. (2008) Nedd4 augments the adaptive immune response by promoting ubiquitin-mediated degradation of Cbl-b in activated T cells. Nat Immunol, 9:1356-63. (PubMed:18931680)

Go Annotations in Tabular Form (Text View) (GO Graph)

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Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IAS Inferred from ancestral sequence
  IBA Inferred from biological aspect of ancestor
  IBD Inferred from biological aspect of descendant
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IKR Inferred from key residues
  IMP Inferred from mutant phenotype
  IMR Inferred from missing residues
  IPI Inferred from physical interaction
  IRD Inferred from rapid divergence
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


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