Automated description from the Alliance of Genome Resources (Release 4.1.0)
Enables several functions, including ionotropic glutamate receptor binding activity; protein phosphorylated amino acid binding activity; and sodium channel inhibitor activity. Involved in negative regulation of vascular endothelial growth factor receptor signaling pathway and regulation of dendrite morphogenesis. Acts upstream of or within several processes, including cellular protein metabolic process; circulatory system development; and neuromuscular junction development. Located in several cellular components, including cytosol; dendritic spine; and glutamatergic synapse. Part of ubiquitin ligase complex. Is active in postsynaptic cytosol. Is expressed in several structures, including alimentary system; eye; genitourinary system; limb; and nervous system. Orthologous to human NEDD4 (NEDD4 E3 ubiquitin protein ligase).