Automated description from the Alliance of Genome Resources (Release 5.3.0)
Enables several functions, including ionotropic glutamate receptor binding activity; protein phosphorylated amino acid binding activity; and sodium channel inhibitor activity. Involved in negative regulation of vascular endothelial growth factor receptor signaling pathway and regulation of dendrite morphogenesis. Acts upstream of or within several processes, including circulatory system development; neuromuscular junction development; and protein monoubiquitination. Located in cytosol; dendritic spine; and membrane. Part of ubiquitin ligase complex. Is active in glutamatergic synapse and postsynaptic cytosol. Is expressed in several structures, including alimentary system; eye; genitourinary system; limb; and nervous system. Orthologous to human NEDD4 (NEDD4 E3 ubiquitin protein ligase).