GO Annotations Graph

• Symbol: Nedd4
• Name: neural precursor cell expressed, developmentally down-regulated 4
• ID: MGI:97297

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

---

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

---

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0031698	beta-2 adrenergic receptor binding	ISO	J:164563
Molecular Function	GO:0019899	enzyme binding	ISO	J:164563
Molecular Function	GO:0035255	ionotropic glutamate receptor binding	IDA	J:230617
Molecular Function	GO:0140677	molecular function activator activity	ISO	J:164563
Molecular Function	GO:0050815	phosphoserine residue binding	IDA	J:140385
Molecular Function	GO:0050816	phosphothreonine residue binding	IDA	J:140385
Molecular Function	GO:0070064	proline-rich region binding	ISO	J:164563
Molecular Function	GO:0070064	proline-rich region binding	IPI	J:75315
Molecular Function	GO:0070064	proline-rich region binding	IPI	J:140926
Molecular Function	GO:0070064	proline-rich region binding	IPI	J:140926
Molecular Function	GO:0005515	protein binding	IPI	J:244072
Molecular Function	GO:0005515	protein binding	IPI	J:56881
Molecular Function	GO:0005515	protein binding	IPI	J:164745
Molecular Function	GO:0005515	protein binding	IPI	J:159070
Molecular Function	GO:0005515	protein binding	IPI	J:122283
Molecular Function	GO:0005515	protein binding	IPI	J:65663
Molecular Function	GO:0005515	protein binding	IPI	J:122283
Molecular Function	GO:0005515	protein binding	IPI	J:187910
Molecular Function	GO:0005515	protein binding	IPI	J:164713
Molecular Function	GO:0005515	protein binding	IPI	J:178643
Molecular Function	GO:0005515	protein binding	IPI	J:164713
Molecular Function	GO:0005515	protein binding	IPI	J:164713
Molecular Function	GO:0005515	protein binding	IPI	J:65663
Molecular Function	GO:0019904	protein domain specific binding	ISO	J:164563
Molecular Function	GO:0070063	RNA polymerase binding	ISO	J:164563
Molecular Function	GO:0019871	sodium channel inhibitor activity	ISO	J:164563
Molecular Function	GO:0019871	sodium channel inhibitor activity	IBA	J:265628
Molecular Function	GO:0019871	sodium channel inhibitor activity	IDA	J:54531
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Molecular Function	GO:0043130	ubiquitin binding	ISO	J:164563
Molecular Function	GO:0061630	ubiquitin protein ligase activity	ISO	J:164563
Molecular Function	GO:0061630	ubiquitin protein ligase activity	IBA	J:265628
Molecular Function	GO:0061630	ubiquitin protein ligase activity	IDA	J:164713
Molecular Function	GO:0061630	ubiquitin protein ligase activity	IDA	J:164713
Molecular Function	GO:0061630	ubiquitin protein ligase activity	IDA	J:41090
Molecular Function	GO:0004842	ubiquitin-protein transferase activity	ISO	J:155856
Cellular Component	GO:0005938	cell cortex	ISO	J:164563
Cellular Component	GO:0000785	chromatin	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IBA	J:265628
Cellular Component	GO:0005737	cytoplasm	IDA	J:89097
Cellular Component	GO:0005829	cytosol	IDA	J:41090
Cellular Component	GO:0005829	cytosol	IDA	J:164173
Cellular Component	GO:0043197	dendritic spine	IDA	J:230617
Cellular Component	GO:0043197	dendritic spine	IBA	J:265628
Cellular Component	GO:0098978	glutamatergic synapse	ISO	J:155856
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:230617
Cellular Component	GO:0098978	glutamatergic synapse	IMP	J:230617
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:230617
Cellular Component	GO:0005794	Golgi apparatus	ISO	J:164563
Cellular Component	GO:0016020	membrane	IDA	J:89097
Cellular Component	GO:0045121	membrane raft	ISO	J:155856
Cellular Component	GO:0005902	microvillus	ISO	J:155856
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0048471	perinuclear region of cytoplasm	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0099524	postsynaptic cytosol	IMP	J:230617
Cellular Component	GO:0099524	postsynaptic cytosol	IDA	J:230617
Cellular Component	GO:0099524	postsynaptic cytosol	IDA	J:230617
Cellular Component	GO:0032991	protein-containing complex	ISO	J:164563
Cellular Component	GO:0000151	ubiquitin ligase complex	IPI	J:65663
Biological Process	GO:0002250	adaptive immune response	IMP	J:143560
Biological Process	GO:0048514	blood vessel morphogenesis	IGI	J:159895
Biological Process	GO:0048514	blood vessel morphogenesis	IMP	J:159895
Biological Process	GO:0034644	cellular response to UV	ISO	J:164563
Biological Process	GO:0003197	endocardial cushion development	IGI	J:159895
Biological Process	GO:0003197	endocardial cushion development	IMP	J:159895
Biological Process	GO:0051649	establishment of localization in cell	IDA	J:54531
Biological Process	GO:0044111	formation of structure involved in a symbiotic process	ISO	J:164563
Biological Process	GO:0042921	glucocorticoid receptor signaling pathway	ISO	J:164563
Biological Process	GO:0045087	innate immune response	ISO	J:164563
Biological Process	GO:0007041	lysosomal transport	ISO	J:164563
Biological Process	GO:2000650	negative regulation of sodium ion transmembrane transporter activity	ISO	J:164563
Biological Process	GO:2000650	negative regulation of sodium ion transmembrane transporter activity	IBA	J:265628
Biological Process	GO:0010766	negative regulation of sodium ion transport	ISO	J:164563
Biological Process	GO:0010766	negative regulation of sodium ion transport	IDA	J:54531
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IMP	J:159895
Biological Process	GO:0030948	negative regulation of vascular endothelial growth factor receptor signaling pathway	IDA	J:159070
Biological Process	GO:0007399	nervous system development	IEA	J:60000
Biological Process	GO:0007528	neuromuscular junction development	IBA	J:265628
Biological Process	GO:0007528	neuromuscular junction development	IMP	J:149227
Biological Process	GO:0031175	neuron projection development	IBA	J:265628
Biological Process	GO:0003151	outflow tract morphogenesis	IGI	J:159895
Biological Process	GO:0003151	outflow tract morphogenesis	IMP	J:159895
Biological Process	GO:0046824	positive regulation of nucleocytoplasmic transport	ISO	J:164563
Biological Process	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	ISO	J:164563
Biological Process	GO:0045732	positive regulation of protein catabolic process	IDA	J:75315
Biological Process	GO:0045732	positive regulation of protein catabolic process	ISO	J:73065
Biological Process	GO:0050847	progesterone receptor signaling pathway	ISO	J:164563
Biological Process	GO:0070534	protein K63-linked ubiquitination	ISO	J:155856
Biological Process	GO:0006513	protein monoubiquitination	IDA	J:178643
Biological Process	GO:0006622	protein targeting to lysosome	ISO	J:164563
Biological Process	GO:0016567	protein ubiquitination	ISO	J:164563
Biological Process	GO:0016567	protein ubiquitination	IBA	J:265628
Biological Process	GO:0016567	protein ubiquitination	ISO	J:227354
Biological Process	GO:0016567	protein ubiquitination	IDA	J:41090
Biological Process	GO:0032801	receptor catabolic process	ISO	J:164563
Biological Process	GO:0032801	receptor catabolic process	IBA	J:265628
Biological Process	GO:0031623	receptor internalization	ISO	J:164563
Biological Process	GO:0031623	receptor internalization	IBA	J:265628
Biological Process	GO:0048814	regulation of dendrite morphogenesis	ISO	J:155856
Biological Process	GO:0048814	regulation of dendrite morphogenesis	IMP	J:164745
Biological Process	GO:0048814	regulation of dendrite morphogenesis	IBA	J:265628
Biological Process	GO:0042391	regulation of membrane potential	ISO	J:164563
Biological Process	GO:0034765	regulation of monoatomic ion transmembrane transport	ISO	J:164563
Biological Process	GO:0099149	regulation of postsynaptic neurotransmitter receptor internalization	ISO	J:155856
Biological Process	GO:1901016	regulation of potassium ion transmembrane transporter activity	ISO	J:164563
Biological Process	GO:0099576	regulation of protein catabolic process at postsynapse, modulating synaptic transmission	ISO	J:155856
Biological Process	GO:0050807	regulation of synapse organization	IBA	J:265628
Biological Process	GO:0050807	regulation of synapse organization	IMP	J:149227
Biological Process	GO:0140252	regulation protein catabolic process at postsynapse	ISO	J:155856
Biological Process	GO:0006814	sodium ion transport	IDA	J:54531
Biological Process	GO:0042110	T cell activation	IMP	J:143560
Biological Process	GO:0006511	ubiquitin-dependent protein catabolic process	ISO	J:164563
Biological Process	GO:0006511	ubiquitin-dependent protein catabolic process	IMP	J:143560
Biological Process	GO:0043162	ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	ISO	J:164563
Biological Process	GO:0046755	viral budding	ISO	J:164563