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Gene Ontology Classifications
microtubule-associated protein tau

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GO curators for mouse genes have assigned the following annotations to the gene product of Mapt. (This text reflects annotations as of Tuesday, May 26, 2015.) MGI curation of this mouse gene is considered complete, including annotations derived from the biomedical literature as of January 19, 2011. If you know of any additional information regarding this mouse gene please let us know. Please supply mouse gene symbol and a PubMed ID.
Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes the microtubule-associated protein tau (MAPT) whose transcript undergoes complex, regulated alternative splicing, giving rise to several mRNA species. MAPT transcripts are differentially expressed in the nervous system, depending on stage of neuronal maturation and neuron type. MAPT gene mutations have been associated with several neurodegenerative disorders such as Alzheimer's disease, Pick's disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy. [provided by RefSeq, Jul 2008]
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by experimental evidence in other organisms
Summary text based on GO annotations supported by structural data
Summary text for additional MGI annotations
  1. Bretin S et al. (2005) Differential expression of CRMP1, CRMP2A, CRMP2B, and CRMP5 in axons or dendrites of distinct neurons in the mouse brain. J Comp Neurol, 486:1-17. (PubMed:15834957)
  2. Brion JP et al. (1988) Dendritic and axonal distribution of the microtubule-associated proteins MAP2 and tau in the cerebellum of the nervous mutant mouse. Brain Res Dev Brain Res, 44:221-32. (PubMed:3147150)
  3. Chapuis J et al. (2013) Increased expression of BIN1 mediates Alzheimer genetic risk by modulating tau pathology. Mol Psychiatry, 18:1225-34. (PubMed:23399914)
  4. de Barreda EG et al. (2010) Tau deficiency leads to the upregulation of BAF-57, a protein involved in neuron-specific gene repression. FEBS Lett, 584:2265-70. (PubMed:20338169)
  5. Dixit R et al. (2008) Differential regulation of dynein and kinesin motor proteins by tau. Science, 319:1086-9. (PubMed:18202255)
  6. Fukami S et al. (2002) Abeta-degrading endopeptidase, neprilysin, in mouse brain: synaptic and axonal localization inversely correlating with Abeta pathology. Neurosci Res, 43:39-56. (PubMed:12074840)
  7. Fuster-Matanzo A et al. (2009) Function of tau protein in adult newborn neurons. FEBS Lett, 583:3063-8. (PubMed:19695252)
  8. Gonzalez-Billault C et al. (2002) Participation of structural microtubule-associated proteins (MAPs) in the development of neuronal polarity. J Neurosci Res, 67:713-9. (PubMed:11891784)
  9. Harada A et al. (1994) Altered microtubule organization in small-calibre axons of mice lacking tau protein. Nature, 369:488-91. (PubMed:8202139)
  10. Hoover AN et al. (2008) C2cd3 is required for cilia formation and Hedgehog signaling in mouse. Development, 135:4049-58. (PubMed:19004860)
  11. Jimenez-Mateos EM et al. (2006) Role of MAP1B in axonal retrograde transport of mitochondria. Biochem J, 397:53-9. (PubMed:16536727)
  12. Li D et al. (2010) Direct association of Sprouty-related protein with an EVH1 domain (SPRED) 1 or SPRED2 with DYRK1A modifies substrate/kinase interactions. J Biol Chem, 285:35374-85. (PubMed:20736167)
  13. Liu Y et al. (2012) PACSIN1, a Tau-interacting protein, regulates axonal elongation and branching by facilitating microtubule instability. J Biol Chem, 287:39911-24. (PubMed:23035120)
  14. Munton RP et al. (2007) Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations. Mol Cell Proteomics, 6:283-93. (PubMed:17114649)
  15. Nakanishi N et al. (2013) Synaptic protein alpha1-takusan mitigates amyloid-beta-induced synaptic loss via interaction with tau and postsynaptic density-95 at postsynaptic sites. J Neurosci, 33:14170-83. (PubMed:23986251)
  16. Pacheco CD et al. (2009) Tau deletion exacerbates the phenotype of Niemann-Pick type C mice and implicates autophagy in pathogenesis. Hum Mol Genet, 18:956-65. (PubMed:19074461)
  17. Sadik G et al. (2009) Phosphorylation of tau at Ser214 mediates its interaction with 14-3-3 protein: implications for the mechanism of tau aggregation. J Neurochem, 108:33-43. (PubMed:19014373)
  18. Vega IE et al. (2008) A novel calcium-binding protein is associated with tau proteins in tauopathy. J Neurochem, 106:96-106. (PubMed:18346207)
  19. Vossel KA et al. (2010) Tau reduction prevents Abeta-induced defects in axonal transport. Science, 330:198. (PubMed:20829454)
  20. Yu DY et al. (2008) Tau binds both subunits of calcineurin, and binding is impaired by calmodulin. Biochim Biophys Acta, 1783:2255-61. (PubMed:18639592)

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Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IAS Inferred from ancestral sequence
  IBA Inferred from biological aspect of ancestor
  IBD Inferred from biological aspect of descendant
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IKR Inferred from key residues
  IMP Inferred from mutant phenotype
  IMR Inferred from missing residues
  IPI Inferred from physical interaction
  IRD Inferred from rapid divergence
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


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