Automated description from the Alliance of Genome Resources (Release 3.1.1)
Exhibits DNA binding activity; microtubule binding activity; and protein kinase binding activity. Involved in several processes, including generation of neurons; regulation of cellular response to stress; and transport along microtubule. Localizes to several cellular components, including cytoskeleton; membrane raft; and postsynaptic density. Predicted to colocalize with membrane and microtubule. Is expressed in several structures, including gut; nervous system; sensory organ; smooth muscle tissue; and urinary system. Used to study Alzheimer's disease. Human ortholog(s) of this gene implicated in dementia (multiple); neurodegenerative disease (multiple); progressive supranuclear palsy; and temporal lobe epilepsy. Orthologous to human MAPT (microtubule associated protein tau).