Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Mertk. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene is a member of the MER/AXL/TYRO3 receptor kinase family and encodes a transmembrane protein with two fibronectin type-III domains, two Ig-like C2-type (immunoglobulin-like) domains, and one tyrosine kinase domain. Mutations in this gene have been associated with disruption of the retinal pigment epithelium (RPE) phagocytosis pathway and onset of autosomal recessive retinitis pigmentosa (RP). [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Mertk
  • participates in the following biological processes:
    • apoptotic cell clearance ^{[5, 8]}
    • platelet activation ^[1]
    • retina development in camera-type eye ^[6]
    • secretion by cell ^[1]
    • substrate adhesion-dependent cell spreading ^[1]
• Researchers have inferred, based on genetic interactions, that the gene product of Mertk
  • participates in the following biological processes:
    • apoptotic cell clearance based on interactions with Axl, Tyro3 ^[8]
    • natural killer cell differentiation based on interactions with Axl, Tyro3 ^[2]
    • negative regulation of lymphocyte activation based on interactions with Axl, Tyro3 ^[4]
    • protein kinase B signaling cascade based on interactions with Gas6 ^[1]
    • spermatogenesis based on interactions with Axl, Tyro3 ^[3]
    • vagina development based on interactions with Axl, Tyro3 ^[7]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Mertk:
  • participates in the following biological processes:
    • phagocytosis
    • positive regulation of phagocytosis
    • protein phosphorylation
  • is located in the following cellular components:
    • cytoplasm
    • extracellular space
    • photoreceptor outer segment
    • rhabdomere

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Summary text based on GO annotations supported by structural data

• Mertk encodes a protein or proteins that contain the following InterPro domains: Fibronectin, type III, Immunoglobulin subtype, Immunoglobulin-like, Immunoglobulin-like fold, Protein kinase, ATP binding site, Protein kinase, catalytic domain, Protein kinase-like domain, Serine-threonine/tyrosine-protein kinase catalytic domain, Tyrosine-protein kinase, active site, Tyrosine-protein kinase, catalytic domain, indicating that the gene product:
  • participates in the following biological processes:
    • protein phosphorylation
  • performs the following molecular functions:
    • ATP binding
    • protein kinase activity
    • protein tyrosine kinase activity
    • transferase activity, transferring phosphorus-containing groups

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Mertk indicates that it:
  • participates in the following biological processes:
    • phosphorylation
    • protein phosphorylation
  • performs the following molecular functions:
    • ATP binding
    • kinase activity
    • nucleotide binding
    • protein tyrosine kinase activity
    • transferase activity
  • is located in the following cellular components:
    • integral to membrane
    • membrane
• Mertk has been associated with the Enzyme Commission numbers: 2.7.10.1, which implies that the gene product:
  • participates in the following biological processes:
    • protein phosphorylation
  • performs the following molecular functions:
    • transmembrane receptor protein tyrosine kinase activity

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References

1. Angelillo-Scherrer A et al. (2005) Role of Gas6 receptors in platelet signaling during thrombus stabilization and implications for antithrombotic therapy. J Clin Invest, 115:237-46. (PubMed:15650770)
2. Caraux A et al. (2006) Natural killer cell differentiation driven by Tyro3 receptor tyrosine kinases. Nat Immunol, 7:747-54. (PubMed:16751775)
3. Lu Q et al. (1999) Tyro-3 family receptors are essential regulators of mammalian spermatogenesis. Nature, 398:723-8. (PubMed:10227296)
4. Lu Q et al. (2001) Homeostatic regulation of the immune system by receptor tyrosine kinases of the Tyro 3 family. Science, 293:306-11. (PubMed:11452127)
5. Seitz HM et al. (2007) Macrophages and dendritic cells use different Axl/Mertk/Tyro3 receptors in clearance of apoptotic cells. J Immunol, 178:5635-42. (PubMed:17442946)
6. Won J et al. (2011) Mouse model resources for vision research. J Ophthalmol, 2011:391384. (PubMed:21052544)
7. Wu H et al. (2008) High incidence of distal vaginal atresia in mice lacking Tyro3 RTK subfamily. Mol Reprod Dev, 75:1775-82. (PubMed:18393392)
8. Xiong W et al. (2008) Gas6 and the Tyro 3 receptor tyrosine kinase subfamily regulate the phagocytic function of Sertoli cells. Reproduction, 135:77-87. (PubMed:18159085)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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